Project measure / variable:   Auwerx2   ogtt_gluc_t15_CD

ID, description, units MPD:114585   ogtt_gluc_t15_CD   glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 15 min   [mg/dL]  CD  
Data set, strains Auwerx2   inbred w/CC8   8 strains     sex: both     age: 16wks
Procedure glucose tolerance
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  STRAIN COMPARISON PLOT
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Auwerx2 - glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 15 min CD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means263.9   mg/dL 283.3   mg/dL
Median of the strain means257.0   mg/dL 283.6   mg/dL
SD of the strain means± 60.2 ± 67.69
Coefficient of variation (CV)0.2281 0.239
Min–max range of strain means195.0   –   366.8   mg/dL 191.8   –   372.8   mg/dL
Mean sample size per strain4.0   mice 4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 5241.0715 5241.0715 1.992 0.1641
strain 6 207183.8249 34530.6375 13.124 < 0.0001
sex:strain 6 42762.8885 7127.1481 2.7088 0.023
Residuals 52 136817.2 2631.1


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 271.8 35.787   5 16.004 0.1317 240.0, 327.0 0.13
129S1/SvImJ m 248.6 83.13   5 37.179 0.3344 113.0, 322.0 -0.51
A/J f 242.2 42.127   5 18.84 0.1739 188.0, 292.0 -0.36
A/J m 205.6 49.034   5 21.929 0.2385 158.0, 288.0 -1.15
C57BL/6J f 366.8 34.96   5 15.635 0.0953 327.0, 411.0 1.71
C57BL/6J m 372.8 82.56   5 36.921 0.2215 278.0, 469.0 1.32
CAST/EiJ f 195.0 0.0   1   0.0 0.0 195.0, 195.0 -1.14
CAST/EiJ m 254.7 26.539   3 15.322 0.1042 229.0, 282.0 -0.42
DBA/2J f 210.2 8.4676   5 3.7868 0.0403 201.0, 222.0 -0.89
DBA/2J m 191.8 40.363   5 18.051 0.2104 147.0, 251.0 -1.35
NOD/ShiLtJ f 319.0 36.592   3 21.127 0.1147 294.0, 361.0 0.92
NOD/ShiLtJ m 312.6 47.516   5 21.25 0.152 260.0, 375.0 0.43
PWK/PhJ f 212.2 35.857   5 16.036 0.169 166.0, 259.0 -0.86
PWK/PhJ m 327.4 40.129   5 17.946 0.1226 283.0, 377.0 0.65
WSB/EiJ f 294.0 33.867   3 19.553 0.1152 272.0, 333.0 0.5
WSB/EiJ m 352.8 75.48   5 33.757 0.214 251.0, 429.0 1.03


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 271.8 22.9394856089 317.8314455068 225.7685544932
129S1/SvImJ m 248.6 22.9394856089 294.6314455068 202.5685544932
A/J f 242.2 22.9394856089 288.2314455068 196.1685544932
A/J m 205.6 22.9394856089 251.6314455068 159.5685544932
C57BL/6J f 366.8 22.9394856089 412.8314455068 320.7685544932
C57BL/6J m 372.8 22.9394856089 418.8314455068 326.7685544932
DBA/2J f 210.2 22.9394856089 256.2314455068 164.1685544932
DBA/2J m 191.8 22.9394856089 237.8314455068 145.7685544932
NOD/ShiLtJ f 319.0 29.6147485779 378.4263406166 259.5736593834
NOD/ShiLtJ m 312.6 22.9394856089 358.6314455068 266.5685544932
PWK/PhJ f 212.2 22.9394856089 258.2314455068 166.1685544932
PWK/PhJ m 327.4 22.9394856089 373.4314455068 281.3685544932
WSB/EiJ f 294.0 29.6147485779 353.4263406166 234.5736593834
WSB/EiJ m 352.8 22.9394856089 398.8314455068 306.7685544932


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 260.2 16.220665831 292.7491472657 227.6508527343
A/J both 223.9 16.220665831 256.4491472657 191.3508527343
C57BL/6J both 369.8 16.220665831 402.3491472657 337.2508527343
DBA/2J both 201.0 16.220665831 233.5491472657 168.4508527343
NOD/ShiLtJ both 315.8 18.7300115679 353.3845178715 278.2154821285
PWK/PhJ both 269.8 16.220665831 302.3491472657 237.2508527343
WSB/EiJ both 323.4 18.7300115679 360.9845178715 285.8154821285




  GWAS USING LINEAR MIXED MODELS