Project measure / variable:   Auwerx2   ogtt_gluc_t0_HFD

ID, description, units MPD:114584   ogtt_gluc_t0_HFD   glucose baseline, glucose tolerance test (pregavage, overnight fast)   [mg/dL]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 16wks
Procedure glucose tolerance
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  STRAIN COMPARISON PLOT
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Auwerx2 - glucose baseline, glucose tolerance test (pregavage, overnight fast) HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means112.7   mg/dL 118.0   mg/dL
Median of the strain means112.1   mg/dL 105.4   mg/dL
SD of the strain means± 32.267 ± 32.279
Coefficient of variation (CV)0.2862 0.2737
Min–max range of strain means59.6   –   151.4   mg/dL 85.0   –   189.0   mg/dL
Mean sample size per strain4.9   mice 3.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 765.2728 765.2728 0.5354 0.4674
strain 7 29482.909 4211.8441 2.9466 0.0106
sex:strain 7 7389.2376 1055.6054 0.7385 0.6403
Residuals 56 80045.2333 1429.3792


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 59.6 8.2946   5 3.7094 0.1392 52.0, 72.0 -1.65
129S1/SvImJ m 85.0 29.698   2   21.0 0.3494 64.0, 106.0 -1.02
A/J f 86.25 4.272   4 2.136 0.0495 81.0, 91.0 -0.82
A/J m 105.4 11.929   5 5.3348 0.1132 92.0, 119.0 -0.39
C57BL/6J f 143.3 32.517   3 18.774 0.2269 108.0, 172.0 0.95
C57BL/6J m 143.5 24.853   4 12.426 0.1732 121.0, 171.0 0.79
CAST/EiJ f 87.6 7.9875   5 3.5721 0.0912 77.0, 99.0 -0.78
CAST/EiJ m 96.5 10.607   2   7.5 0.1099 89.0, 104.0 -0.66
DBA/2J f 95.4 11.589   5 5.1827 0.1215 79.0, 111.0 -0.54
DBA/2J m 113.0 21.237   5 9.4974 0.1879 86.0, 145.0 -0.15
NOD/ShiLtJ f 112.1 86.54   10 27.367 0.772 73.0, 357.0 -0.02
NOD/ShiLtJ m 98.6 8.6487   5 3.8678 0.0877 86.0, 108.0 -0.6
NZO/HlLtJ f 151.4 33.916   5 15.168 0.224 109.0, 198.0 1.2
NZO/HlLtJ m 189.0 0.0   1   0.0 0.0 189.0, 189.0 2.2
PWK/PhJ f 142.2 5.058   4 2.529 0.0356 136.0, 148.0 0.91
PWK/PhJ m 99.2 12.478   5 5.5803 0.1258 79.0, 112.0 -0.58
WSB/EiJ f 136.7 19.502   3 11.26 0.1427 123.0, 159.0 0.74
WSB/EiJ m 131.4 24.613   5 11.007 0.1873 110.0, 173.0 0.42


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 59.6 16.9078630623 93.4705197551 25.7294802449
129S1/SvImJ m 85.0 26.7336788215 138.5539939799 31.4460060201
A/J f 86.25 18.9035655808 124.1183923028 48.3816076972
A/J m 105.4 16.9078630623 139.2705197551 71.5294802449
C57BL/6J f 143.3333333333 21.8279573534 187.059986313 99.6066803537
C57BL/6J m 143.5 18.9035655808 181.3683923028 105.6316076972
CAST/EiJ f 87.6 16.9078630623 121.4705197551 53.7294802449
CAST/EiJ m 96.5 26.7336788215 150.0539939799 42.9460060201
DBA/2J f 95.4 16.9078630623 129.2705197551 61.5294802449
DBA/2J m 113.0 16.9078630623 146.8705197551 79.1294802449
NOD/ShiLtJ f 112.1 11.9556646267 136.0500742011 88.1499257989
NOD/ShiLtJ m 98.6 16.9078630623 132.4705197551 64.7294802449
PWK/PhJ f 142.25 18.9035655808 180.1183923028 104.3816076972
PWK/PhJ m 99.2 16.9078630623 133.0705197551 65.3294802449
WSB/EiJ f 136.6666666667 21.8279573534 180.3933196463 92.940013687
WSB/EiJ m 131.4 16.9078630623 165.2705197551 97.5294802449


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 72.3 15.8158576804 103.9829701089 40.6170298911
A/J both 95.825 12.6808972967 121.2278898163 70.4221101837
C57BL/6J both 143.4166666667 14.4378366964 172.339129029 114.4942043043
CAST/EiJ both 92.05 15.8158576804 123.7329701089 60.3670298911
DBA/2J both 104.2 11.9556646267 128.1500742011 80.2499257989
NOD/ShiLtJ both 105.35 10.3539092859 126.0913726807 84.6086273193
PWK/PhJ both 120.725 12.6808972967 146.1278898163 95.3221101837
WSB/EiJ both 134.0333333333 13.8052123812 161.6884969076 106.3781697591




  GWAS USING LINEAR MIXED MODELS