Project measure / variable:   Schoonjans1   THDCA_liver_CD

ID, description, units MPD:112845   THDCA_liver_CD   bile acid taurohyodeoxycholic acid amount in liver, at 29 wks   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 29wks
Procedure biomarker quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid taurohyodeoxycholic acid amount in liver, at 29 wks CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means1.0174   ng/mL
Median of the strain means0.79657   ng/mL
SD of the strain means± 0.6232
Coefficient of variation (CV)0.6126
Min–max range of strain means0.14812   –   2.6318   ng/mL
Mean sample size per strain4.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 64.8194 1.852 5.2668 < 0.0001
Residuals 134 47.1193 0.3516


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 0.7008 0.12442   4 0.06221 0.1775 0.58686, 0.87349 -0.51
BXD100 m 0.59478 0.24025   6 0.09808 0.4039 0.27125, 0.9416 -0.68
BXD11 m 0.60925 0.39264   4 0.19632 0.6445 0.23556, 1.0845 -0.65
BXD12 m 2.4291 0.22537   4 0.11269 0.0928 2.2271, 2.7133 2.27
BXD27 m 0.73788 0.20226   4 0.10113 0.2741 0.47945, 0.9479 -0.45
BXD32 m 0.79072 0.38493   5 0.17214 0.4868 0.41252, 1.3017 -0.36
BXD34 m 0.76618 0.21504   5 0.09617 0.2807 0.48771, 1.064 -0.4
BXD39 m 1.1049 0.12911   5 0.05774 0.1168 0.91939, 1.2234 0.14
BXD40 m 1.4954 0.51706   5 0.23124 0.3458 0.93288, 2.3325 0.77
BXD43 m 0.73191 0.60027   3 0.34657 0.8201 0.33427, 1.4224 -0.46
BXD45 m 1.6173 0.24058   4 0.12029 0.1488 1.3652, 1.8666 0.96
BXD48 m 2.6318 2.6371   5 1.1794 1.002 1.0215, 7.3006 2.59
BXD48a m 0.59686 0.2894   4 0.1447 0.4849 0.24145, 0.90019 -0.67
BXD49 m 0.58565 0.24991   4 0.12495 0.4267 0.30312, 0.90003 -0.69
BXD51 m 0.62239 0.2039   5 0.09118 0.3276 0.35258, 0.91265 -0.63
BXD53 m 1.1261 0.57217   5 0.25588 0.5081 0.67421, 2.0506 0.17
BXD55 m 0.80242 0.33959   5 0.15187 0.4232 0.36829, 1.2785 -0.34
BXD6 m 0.14812 0.14687   5 0.06568 0.9915 0.06338, 0.40964 -1.39
BXD62 m 0.4141 0.1158   5 0.05179 0.2796 0.31609, 0.60609 -0.97
BXD63 m 1.3097 0.35748   5 0.15987 0.2729 0.89265, 1.7959 0.47
BXD64 m 1.1177 0.65565   3 0.37854 0.5866 0.7101, 1.874 0.16
BXD66 m 0.39806 0.12472   7 0.04714 0.3133 0.20842, 0.52895 -0.99
BXD67 m 0.18003 0.05776   4 0.02888 0.3208 0.11268, 0.24413 -1.34
BXD69 m 1.7478 0.53783   5 0.24053 0.3077 0.95354, 2.1852 1.17
BXD73 m 1.384 0.36039   5 0.16117 0.2604 0.90543, 1.8443 0.59
BXD75 m 0.82682 0.24396   5 0.1091 0.2951 0.51928, 1.0846 -0.31
BXD77 m 0.73109 0.30912   5 0.13824 0.4228 0.39661, 1.162 -0.46
BXD79 m 1.5442 0.70181   5 0.31386 0.4545 0.88194, 2.556 0.85
BXD8 m 1.2569 0.30091   5 0.13457 0.2394 0.82777, 1.5544 0.38
BXD81 m 1.3945 0.89844   4 0.44922 0.6443 0.6222, 2.5295 0.61
BXD84 m 0.69188 0.28239   5 0.12629 0.4082 0.41734, 1.1386 -0.52
BXD87 m 2.5971 0.94305   5 0.42174 0.3631 1.6521, 3.6756 2.53
BXD89 m 1.2607 0.27967   5 0.12507 0.2218 0.81698, 1.5536 0.39
BXD90 m 0.46574 0.17144   5 0.07667 0.3681 0.18152, 0.62011 -0.89
C57BL/6J m 0.95074 0.10796   5 0.04828 0.1136 0.79858, 1.094 -0.11
DBA/2J m 0.26321 0.08194   5 0.03664 0.3113 0.15715, 0.34451 -1.21


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 0.7007975 0.2964946253 1.2872122071 0.1143827929
BXD100 m 0.5947816667 0.2420868478 1.07358727 0.1159760633
BXD11 m 0.60925 0.2964946253 1.1956647071 0.0228352929
BXD12 m 2.4291 0.2964946253 3.0155147071 1.8426852929
BXD27 m 0.7378775 0.2964946253 1.3242922071 0.1514627929
BXD32 m 0.790718 0.2651928549 1.3152232592 0.2662127408
BXD34 m 0.76618 0.2651928549 1.2906852592 0.2416747408
BXD39 m 1.104898 0.2651928549 1.6294032592 0.5803927408
BXD40 m 1.495416 0.2651928549 2.0199212592 0.9709107408
BXD43 m 0.7319133333 0.3423625035 1.4090467113 0.0547799553
BXD45 m 1.6173 0.2964946253 2.2037147071 1.0308852929
BXD48 m 2.63178 0.2651928549 3.1562852592 2.1072747408
BXD48a m 0.5968625 0.2964946253 1.1832772071 0.0104477929
BXD49 m 0.5856525 0.2964946253 1.1720672071 -0.0007622071
BXD51 m 0.622388 0.2651928549 1.1468932592 0.0978827408
BXD53 m 1.126126 0.2651928549 1.6506312592 0.6016207408
BXD55 m 0.802418 0.2651928549 1.3269232592 0.2779127408
BXD6 m 0.148124 0.2651928549 0.6726292592 -0.3763812592
BXD62 m 0.414096 0.2651928549 0.9386012592 -0.1104092592
BXD63 m 1.30971 0.2651928549 1.8342152592 0.7852047408
BXD64 m 1.1176866667 0.3423625035 1.7948200447 0.4405532887
BXD66 m 0.3980614286 0.2241288696 0.84134928 -0.0452264229
BXD67 m 0.1800275 0.2964946253 0.7664422071 -0.4063872071
BXD69 m 1.747828 0.2651928549 2.2723332592 1.2233227408
BXD73 m 1.383966 0.2651928549 1.9084712592 0.8594607408
BXD75 m 0.826824 0.2651928549 1.3513292592 0.3023187408
BXD77 m 0.731088 0.2651928549 1.2555932592 0.2065827408
BXD79 m 1.544208 0.2651928549 2.0687132592 1.0197027408
BXD8 m 1.256894 0.2651928549 1.7813992592 0.7323887408
BXD81 m 1.3945025 0.2964946253 1.9809172071 0.8080877929
BXD84 m 0.691876 0.2651928549 1.2163812592 0.1673707408
BXD87 m 2.59708 0.2651928549 3.1215852592 2.0725747408
BXD89 m 1.260736 0.2651928549 1.7852412592 0.7362307408
BXD90 m 0.465736 0.2651928549 0.9902412592 -0.0587692592
C57BL/6J m 0.950742 0.2651928549 1.4752472592 0.4262367408
DBA/2J m 0.263206 0.2651928549 0.7877112592 -0.2612992592




  GWAS USING LINEAR MIXED MODELS