Project measure / variable:   Schoonjans1   TDCA_liver_HFD

ID, description, units MPD:112844   TDCA_liver_HFD   bile acid taurodeoxycholic acid amount in liver, at 29 wks   [ng/mL]  HFD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 29wks
Procedure biomarker quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid taurodeoxycholic acid amount in liver, at 29 wks HFD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means0.81397   ng/mL
Median of the strain means0.58956   ng/mL
SD of the strain means± 0.85756
Coefficient of variation (CV)1.0536
Min–max range of strain means0.12135   –   4.9257   ng/mL
Mean sample size per strain4.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 127.742 3.6498 23.3255 < 0.0001
Residuals 141 22.0624 0.1565


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 4.9257 0.89011   5 0.39807 0.1807 3.5331, 5.7378 4.79
BXD100 m 0.21208 0.11258   7 0.04255 0.5308 0.10902, 0.35706 -0.7
BXD11 m 0.35825 0.38431   3 0.22188 1.0727 0.1275, 0.80189 -0.53
BXD12 m 0.77752 0.57772   4 0.28886 0.743 0.35963, 1.6219 -0.04
BXD27 m 0.59798 0.263   5 0.11762 0.4398 0.31458, 1.0061 -0.25
BXD32 m 0.62938 0.27697   4 0.13848 0.4401 0.31573, 0.88901 -0.22
BXD34 m 0.71108 0.12355   4 0.06177 0.1737 0.59468, 0.83658 -0.12
BXD39 m 0.32704 0.13469   5 0.06024 0.4118 0.20841, 0.54209 -0.57
BXD40 m 0.12135 0.02098   5 0.0093805 0.1729 0.0878, 0.14558 -0.81
BXD43 m 0.12258 0.08516   5 0.03808 0.6947 0.058, 0.25101 -0.81
BXD45 m 0.50551 0.24771   5 0.11078 0.49 0.25253, 0.83928 -0.36
BXD48 m 1.028 0.66241   5 0.29624 0.6444 0.47869, 1.9667 0.25
BXD48a m 0.58114 0.36005   5 0.16102 0.6196 0.24502, 1.1581 -0.27
BXD49 m 1.8511 0.65693   5 0.29379 0.3549 1.0904, 2.8355 1.21
BXD51 m 1.0505 0.15812   5 0.07071 0.1505 0.81595, 1.2154 0.28
BXD53 m 0.38709 0.34833   5 0.15578 0.8999 0.18831, 1.004 -0.5
BXD55 m 0.52386 0.25559   5 0.1143 0.4879 0.25295, 0.91786 -0.34
BXD6 m 0.25322 0.13341   5 0.05966 0.5268 0.11857, 0.45475 -0.65
BXD62 m 0.24239 0.08927   5 0.03992 0.3683 0.15133, 0.35122 -0.67
BXD63 m 1.6791 0.38977   5 0.17431 0.2321 1.1853, 2.0936 1.01
BXD64 m 0.40927 0.4048   5 0.18103 0.9891 0.09246, 1.0798 -0.47
BXD66 m 0.1938 0.04703   9 0.01568 0.2427 0.11179, 0.26693 -0.72
BXD67 m 0.47795 0.22669   5 0.10138 0.4743 0.25106, 0.74551 -0.39
BXD69 m 1.1235 0.38556   5 0.17243 0.3432 0.62243, 1.6001 0.36
BXD73 m 0.37266 0.12545   5 0.0561 0.3366 0.24408, 0.52419 -0.51
BXD75 m 2.3549 1.307   4 0.65349 0.555 1.0794, 3.77 1.8
BXD77 m 0.97735 0.76213   5 0.34084 0.7798 0.0184, 2.0647 0.19
BXD79 m 0.27707 0.14227   5 0.06363 0.5135 0.09586, 0.45344 -0.63
BXD8 m 0.50342 0.1779   4 0.08895 0.3534 0.29488, 0.71976 -0.36
BXD81 m 1.0521 0.20947   5 0.09368 0.1991 0.85904, 1.3715 0.28
BXD84 m 0.76649 0.12467   5 0.05576 0.1627 0.61116, 0.92037 -0.06
BXD87 m 0.74209 0.26065   5 0.11657 0.3512 0.5829, 1.1958 -0.08
BXD89 m 0.82242 0.30709   5 0.13734 0.3734 0.31748, 1.1004 0.01
BXD90 m 0.47209 0.31925   3 0.18432 0.6762 0.24325, 0.8368 -0.4
C57BL/6J m 1.0846 0.26056   5 0.11653 0.2402 0.84887, 1.4578 0.32
DBA/2J m 0.78825 0.36732   5 0.16427 0.466 0.49891, 1.4197 -0.03


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 4.92568 0.1769017452 5.2754026306 4.5759573694
BXD100 m 0.2120771429 0.1495092627 0.5076467121 -0.0834924263
BXD11 m 0.35825 0.2283791711 0.8097399747 -0.0932399747
BXD12 m 0.77752 0.1977821639 1.1685217876 0.3865182124
BXD27 m 0.597978 0.1769017452 0.9477006306 0.2482553694
BXD32 m 0.6293825 0.1977821639 1.0203842876 0.2383807124
BXD34 m 0.7110825 0.1977821639 1.1020842876 0.3200807124
BXD39 m 0.327042 0.1769017452 0.6767646306 -0.0226806306
BXD40 m 0.121348 0.1769017452 0.4710706306 -0.2283746306
BXD43 m 0.122576 0.1769017452 0.4722986306 -0.2271466306
BXD45 m 0.505506 0.1769017452 0.8552286306 0.1557833694
BXD48 m 1.028028 0.1769017452 1.3777506306 0.6783053694
BXD48a m 0.581138 0.1769017452 0.9308606306 0.2314153694
BXD49 m 1.85114 0.1769017452 2.2008626306 1.5014173694
BXD51 m 1.050468 0.1769017452 1.4001906306 0.7007453694
BXD53 m 0.38709 0.1769017452 0.7368126306 0.0373673694
BXD55 m 0.523864 0.1769017452 0.8735866306 0.1741413694
BXD6 m 0.253218 0.1769017452 0.6029406306 -0.0965046306
BXD62 m 0.242392 0.1769017452 0.5921146306 -0.1073306306
BXD63 m 1.67912 0.1769017452 2.0288426306 1.3293973694
BXD64 m 0.40927 0.1769017452 0.7589926306 0.0595473694
BXD66 m 0.1937977778 0.1318547759 0.4544656362 -0.0668700806
BXD67 m 0.477946 0.1769017452 0.8276686306 0.1282233694
BXD69 m 1.123464 0.1769017452 1.4731866306 0.7737413694
BXD73 m 0.372656 0.1769017452 0.7223786306 0.0229333694
BXD75 m 2.3549 0.1977821639 2.7459017876 1.9638982124
BXD77 m 0.977354 0.1769017452 1.3270766306 0.6276313694
BXD79 m 0.277072 0.1769017452 0.6267946306 -0.0726506306
BXD8 m 0.5034175 0.1977821639 0.8944192876 0.1124157124
BXD81 m 1.052114 0.1769017452 1.4018366306 0.7023913694
BXD84 m 0.76649 0.1769017452 1.1162126306 0.4167673694
BXD87 m 0.742088 0.1769017452 1.0918106306 0.3923653694
BXD89 m 0.822416 0.1769017452 1.1721386306 0.4726933694
BXD90 m 0.4720933333 0.2283791711 0.923583308 0.0206033587
C57BL/6J m 1.08458 0.1769017452 1.4343026306 0.7348573694
DBA/2J m 0.788252 0.1769017452 1.1379746306 0.4385293694




  GWAS USING LINEAR MIXED MODELS