Project measure / variable:   Schoonjans1   TDCA_liver_CD

ID, description, units MPD:112843   TDCA_liver_CD   bile acid taurodeoxycholic acid amount in liver, at 29 wks   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 29wks
Procedure biomarker quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid taurodeoxycholic acid amount in liver, at 29 wks CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means0.87217   ng/mL
Median of the strain means0.7693   ng/mL
SD of the strain means± 0.64578
Coefficient of variation (CV)0.7404
Min–max range of strain means0.04669   –   2.3735   ng/mL
Mean sample size per strain4.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 70.9528 2.0272 8.0908 < 0.0001
Residuals 134 33.5751 0.2506


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 1.6223 0.45795   4 0.22898 0.2823 1.179, 2.068 1.16
BXD100 m 0.33821 0.11737   6 0.04792 0.347 0.23965, 0.55847 -0.83
BXD11 m 0.41699 0.1282   4 0.0641 0.3074 0.24435, 0.52906 -0.7
BXD12 m 0.76395 0.75098   4 0.37549 0.983 0.32301, 1.8844 -0.17
BXD27 m 0.56843 0.21694   4 0.10847 0.3817 0.3335, 0.79976 -0.47
BXD32 m 0.99658 0.33963   5 0.15189 0.3408 0.72147, 1.5487 0.19
BXD34 m 0.24281 0.0871   5 0.03895 0.3587 0.16487, 0.37197 -0.97
BXD39 m 0.26047 0.16052   5 0.07179 0.6163 0.00027273, 0.3956 -0.95
BXD40 m 0.2999 0.044   5 0.01968 0.1467 0.23233, 0.33946 -0.89
BXD43 m 1.265 1.299   3 0.74998 1.0269 0.19771, 2.7114 0.61
BXD45 m 1.0562 0.15948   4 0.07974 0.151 0.82072, 1.1568 0.28
BXD48 m 2.3735 1.6103   5 0.72014 0.6784 1.0887, 5.1105 2.32
BXD48a m 0.40317 0.13319   4 0.0666 0.3304 0.29759, 0.57467 -0.73
BXD49 m 0.89505 0.1329   4 0.06645 0.1485 0.73095, 1.0557 0.04
BXD51 m 0.85261 0.28556   5 0.12771 0.3349 0.52891, 1.1909 -0.03
BXD53 m 0.41387 0.20284   5 0.09071 0.4901 0.22239, 0.75521 -0.71
BXD55 m 1.4427 0.54835   5 0.24523 0.3801 0.84297, 2.2335 0.88
BXD6 m 0.04669 0.03366   5 0.01505 0.7209 0.00062562, 0.08543 -1.28
BXD62 m 0.35155 0.14359   5 0.06422 0.4084 0.21516, 0.50535 -0.81
BXD63 m 1.7126 0.49701   5 0.22227 0.2902 1.0828, 2.4578 1.3
BXD64 m 0.22378 0.07598   3 0.04387 0.3395 0.16719, 0.31014 -1.0
BXD66 m 0.33214 0.08686   7 0.03283 0.2615 0.22963, 0.48068 -0.84
BXD67 m 0.13875 0.02505   4 0.01252 0.1805 0.11915, 0.17523 -1.14
BXD69 m 1.1715 0.63235   5 0.2828 0.5398 0.4322, 2.1313 0.46
BXD73 m 1.2363 0.53131   5 0.23761 0.4298 0.6319, 1.9176 0.56
BXD75 m 1.072 0.18062   5 0.08078 0.1685 0.95214, 1.386 0.31
BXD77 m 0.33602 0.15353   5 0.06866 0.4569 0.14554, 0.52231 -0.83
BXD79 m 2.3181 1.4233   5 0.63652 0.614 0.74015, 4.4898 2.24
BXD8 m 0.22728 0.08592   5 0.03843 0.3781 0.13604, 0.3226 -1.0
BXD81 m 1.1543 0.40184   4 0.20092 0.3481 0.83794, 1.7251 0.44
BXD84 m 1.23 0.29109   5 0.13018 0.2367 0.84664, 1.5978 0.55
BXD87 m 2.3195 0.52405   5 0.23436 0.2259 1.6862, 2.896 2.24
BXD89 m 0.77464 0.19283   5 0.08624 0.2489 0.45933, 0.94855 -0.15
BXD90 m 0.39996 0.08675   5 0.0388 0.2169 0.30143, 0.50844 -0.73
C57BL/6J m 1.5934 0.32865   5 0.14698 0.2063 1.0689, 1.8889 1.12
DBA/2J m 0.54787 0.06438   5 0.02879 0.1175 0.44682, 0.62662 -0.5


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 1.622275 0.2502800685 2.1172853663 1.1272646337
BXD100 m 0.3382083333 0.2043528202 0.7423826049 -0.0659659383
BXD11 m 0.4169875 0.2502800685 0.9119978663 -0.0780228663
BXD12 m 0.76395 0.2502800685 1.2589603663 0.2689396337
BXD27 m 0.5684275 0.2502800685 1.0634378663 0.0734171337
BXD32 m 0.996584 0.2238572987 1.4393347315 0.5538332685
BXD34 m 0.242814 0.2238572987 0.6855647315 -0.1999367315
BXD39 m 0.260474546 0.2238572987 0.7032252775 -0.1822761855
BXD40 m 0.299904 0.2238572987 0.7426547315 -0.1428467315
BXD43 m 1.2650333333 0.2889985299 1.8366220698 0.6934445969
BXD45 m 1.056205 0.2502800685 1.5512153663 0.5611946337
BXD48 m 2.37352 0.2238572987 2.8162707315 1.9307692685
BXD48a m 0.4031725 0.2502800685 0.8981828663 -0.0918378663
BXD49 m 0.895055 0.2502800685 1.3900653663 0.4000446337
BXD51 m 0.852612 0.2238572987 1.2953627315 0.4098612685
BXD53 m 0.413866 0.2238572987 0.8566167315 -0.0288847315
BXD55 m 1.442654 0.2238572987 1.8854047315 0.9999032685
BXD6 m 0.046693124 0.2238572987 0.4894438555 -0.3960576075
BXD62 m 0.351554 0.2238572987 0.7943047315 -0.0911967315
BXD63 m 1.71262 0.2238572987 2.1553707315 1.2698692685
BXD64 m 0.2237833333 0.2889985299 0.7953720698 -0.3478054031
BXD66 m 0.3321414286 0.1891939484 0.706334093 -0.0420512359
BXD67 m 0.1387475 0.2502800685 0.6337578663 -0.3562628663
BXD69 m 1.17151 0.2238572987 1.6142607315 0.7287592685
BXD73 m 1.236304 0.2238572987 1.6790547315 0.7935532685
BXD75 m 1.07198 0.2238572987 1.5147307315 0.6292292685
BXD77 m 0.336018 0.2238572987 0.7787687315 -0.1067327315
BXD79 m 2.31811 0.2238572987 2.7608607315 1.8753592685
BXD8 m 0.22728 0.2238572987 0.6700307315 -0.2154707315
BXD81 m 1.154285 0.2502800685 1.6492953663 0.6592746337
BXD84 m 1.229988 0.2238572987 1.6727387315 0.7872372685
BXD87 m 2.3195 0.2238572987 2.7622507315 1.8767492685
BXD89 m 0.774638 0.2238572987 1.2173887315 0.3318872685
BXD90 m 0.399958 0.2238572987 0.8427087315 -0.0427927315
C57BL/6J m 1.59342 0.2238572987 2.0361707315 1.1506692685
DBA/2J m 0.54787 0.2238572987 0.9906207315 0.1051192685




  GWAS USING LINEAR MIXED MODELS