Project measure / variable:   Schoonjans1   TCDCA_liver_HFD

ID, description, units MPD:112842   TCDCA_liver_HFD   bile acid taurochenodeoxycholic acid amount in liver, at 29 wks   [ng/mL]  HFD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 29wks
Procedure biomarker quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid taurochenodeoxycholic acid amount in liver, at 29 wks HFD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means2.4513   ng/mL
Median of the strain means2.3615   ng/mL
SD of the strain means± 0.86979
Coefficient of variation (CV)0.3548
Min–max range of strain means1.1165   –   4.9078   ng/mL
Mean sample size per strain4.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 122.8675 3.5105 6.1379 < 0.0001
Residuals 141 80.6431 0.5719


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 3.0331 1.5412   5 0.68926 0.5081 1.498, 4.978 0.67
BXD100 m 1.8952 0.53083   7 0.20063 0.2801 1.142, 2.6003 -0.64
BXD11 m 1.5602 0.35706   3 0.20615 0.2288 1.1518, 1.8132 -1.02
BXD12 m 2.0997 0.32871   4 0.16435 0.1566 1.6273, 2.3487 -0.4
BXD27 m 3.4091 1.2705   5 0.56817 0.3727 2.3742, 5.5874 1.1
BXD32 m 3.3264 0.22115   4 0.11058 0.0665 3.1447, 3.6477 1.01
BXD34 m 4.9078 1.4848   4 0.74238 0.3025 3.9486, 7.0847 2.82
BXD39 m 2.2391 0.46588   5 0.20835 0.2081 1.697, 2.8281 -0.24
BXD40 m 2.4367 0.79839   5 0.35705 0.3277 1.8655, 3.8463 -0.02
BXD43 m 2.0012 0.66167   5 0.29591 0.3306 1.104, 2.9172 -0.52
BXD45 m 3.4078 0.84401   5 0.37745 0.2477 2.5496, 4.6393 1.1
BXD48 m 2.7436 0.2266   5 0.10134 0.0826 2.3649, 2.9706 0.34
BXD48a m 3.8311 1.2638   5 0.5652 0.3299 2.2295, 5.4234 1.59
BXD49 m 2.0137 0.50247   5 0.22471 0.2495 1.3946, 2.5387 -0.5
BXD51 m 2.6996 0.32838   5 0.14686 0.1216 2.2085, 3.1227 0.29
BXD53 m 2.391 0.64749   5 0.28956 0.2708 1.7405, 3.2818 -0.07
BXD55 m 2.3299 0.81462   5 0.36431 0.3496 1.3845, 3.4248 -0.14
BXD6 m 1.1709 0.05045   5 0.02256 0.0431 1.1149, 1.2231 -1.47
BXD62 m 2.9559 0.78881   5 0.35277 0.2669 2.2199, 4.2166 0.58
BXD63 m 1.2155 0.11789   5 0.05272 0.097 1.1066, 1.3531 -1.42
BXD64 m 2.7568 0.75994   5 0.33986 0.2757 2.1215, 3.9247 0.35
BXD66 m 1.9668 0.24351   9 0.08117 0.1238 1.6725, 2.3605 -0.56
BXD67 m 1.3796 0.16261   5 0.07272 0.1179 1.2296, 1.6536 -1.23
BXD69 m 3.3685 1.5376   5 0.68762 0.4564 2.0105, 5.902 1.05
BXD73 m 2.332 0.24052   5 0.10757 0.1031 2.003, 2.6714 -0.14
BXD75 m 2.9762 1.1651   4 0.58254 0.3915 2.0087, 4.3496 0.6
BXD77 m 2.8591 0.70324   5 0.3145 0.246 1.8509, 3.7469 0.47
BXD79 m 1.7154 0.78858   5 0.35267 0.4597 1.0218, 3.0071 -0.85
BXD8 m 1.146 0.22624   4 0.11312 0.1974 0.90309, 1.45 -1.5
BXD81 m 2.6546 0.73427   5 0.32837 0.2766 1.8274, 3.7811 0.23
BXD84 m 1.5196 0.18509   5 0.08278 0.1218 1.2253, 1.7172 -1.07
BXD87 m 1.1165 0.38511   5 0.17223 0.3449 0.60728, 1.6565 -1.53
BXD89 m 2.7244 0.60713   5 0.27152 0.2228 1.7904, 3.2776 0.31
BXD90 m 1.9233 0.49637   3 0.28658 0.2581 1.5903, 2.4938 -0.61
C57BL/6J m 3.9423 1.1682   5 0.52242 0.2963 2.1716, 5.3519 1.71
DBA/2J m 2.1978 0.53225   5 0.23803 0.2422 1.7285, 3.1059 -0.29


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 3.03306 0.3382120474 3.7016820463 2.3644379537
BXD100 m 1.8951857143 0.2858413509 2.4602744815 1.330096947
BXD11 m 1.5602333333 0.4366298757 2.4234206834 0.6970459832
BXD12 m 2.09965 0.3781325644 2.8471921734 1.3521078266
BXD27 m 3.40914 0.3382120474 4.0777620463 2.7405179537
BXD32 m 3.326425 0.3781325644 4.0739671734 2.5788828266
BXD34 m 4.90775 0.3781325644 5.6552921734 4.1602078266
BXD39 m 2.23912 0.3382120474 2.9077420463 1.5704979537
BXD40 m 2.4367 0.3382120474 3.1053220463 1.7680779537
BXD43 m 2.0012 0.3382120474 2.6698220463 1.3325779537
BXD45 m 3.4078 0.3382120474 4.0764220463 2.7391779537
BXD48 m 2.74356 0.3382120474 3.4121820463 2.0749379537
BXD48a m 3.83112 0.3382120474 4.4997420463 3.1624979537
BXD49 m 2.01374 0.3382120474 2.6823620463 1.3451179537
BXD51 m 2.69958 0.3382120474 3.3682020463 2.0309579537
BXD53 m 2.39102 0.3382120474 3.0596420463 1.7223979537
BXD55 m 2.3299 0.3382120474 2.9985220463 1.6612779537
BXD6 m 1.17094 0.3382120474 1.8395620463 0.5023179537
BXD62 m 2.95586 0.3382120474 3.6244820463 2.2872379537
BXD63 m 1.2155 0.3382120474 1.8841220463 0.5468779537
BXD64 m 2.75682 0.3382120474 3.4254420463 2.0881979537
BXD66 m 1.9668111111 0.2520883763 2.4651725601 1.4684496622
BXD67 m 1.37964 0.3382120474 2.0482620463 0.7110179537
BXD69 m 3.36854 0.3382120474 4.0371620463 2.6999179537
BXD73 m 2.33198 0.3382120474 3.0006020463 1.6633579537
BXD75 m 2.9762 0.3781325644 3.7237421734 2.2286578266
BXD77 m 2.85914 0.3382120474 3.5277620463 2.1905179537
BXD79 m 1.71544 0.3382120474 2.3840620463 1.0468179537
BXD8 m 1.1460475 0.3781325644 1.8935896734 0.3985053266
BXD81 m 2.65464 0.3382120474 3.3232620463 1.9860179537
BXD84 m 1.51962 0.3382120474 2.1882420463 0.8509979537
BXD87 m 1.116546 0.3382120474 1.7851680463 0.4479239537
BXD89 m 2.72444 0.3382120474 3.3930620463 2.0558179537
BXD90 m 1.9233 0.4366298757 2.7864873501 1.0601126499
C57BL/6J m 3.94232 0.3382120474 4.6109420463 3.2736979537
DBA/2J m 2.19782 0.3382120474 2.8664420463 1.5291979537




  GWAS USING LINEAR MIXED MODELS