Project measure / variable:   Schoonjans1   TCA_liver_CD

ID, description, units MPD:112839   TCA_liver_CD   bile acid taurocholic acid amount in liver, at 29 wks   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 29wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid taurocholic acid amount in liver, at 29 wks CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means21.849   ng/mL
Median of the strain means20.358   ng/mL
SD of the strain means± 9.0451
Coefficient of variation (CV)0.414
Min–max range of strain means10.863   –   54.72   ng/mL
Mean sample size per strain4.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 14044.5167 401.2719 4.2589 < 0.0001
Residuals 134 12625.4153 94.2195


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 26.241 3.8111   4 1.9056 0.1452 22.943, 30.06 0.49
BXD100 m 21.894 3.4432   6 1.4057 0.1573 17.898, 25.922 0.0
BXD11 m 18.557 7.2393   4 3.6197 0.3901 9.0522, 25.12 -0.36
BXD12 m 22.067 12.7   4 6.3502 0.5755 14.048, 40.956 0.02
BXD27 m 24.266 4.1374   4 2.0687 0.1705 18.805, 28.451 0.27
BXD32 m 20.254 6.8879   5 3.0804 0.3401 10.668, 28.958 -0.18
BXD34 m 16.222 3.5069   5 1.5683 0.2162 12.423, 20.097 -0.62
BXD39 m 22.344 6.0673   5 2.7134 0.2715 14.426, 28.559 0.05
BXD40 m 15.506 6.7164   5 3.0036 0.4332 7.9621, 24.085 -0.7
BXD43 m 21.827 6.7161   3 3.8775 0.3077 14.175, 26.743 0.0
BXD45 m 17.105 2.4587   4 1.2293 0.1437 14.132, 19.175 -0.52
BXD48 m 33.893 26.336   5 11.778 0.777 14.776, 79.0 1.33
BXD48a m 16.608 7.1197   4 3.5598 0.4287 11.786, 27.069 -0.58
BXD49 m 13.505 5.9386   4 2.9693 0.4397 7.9443, 21.542 -0.92
BXD51 m 33.859 11.217   5 5.0164 0.3313 22.479, 45.721 1.33
BXD53 m 26.861 25.878   5 11.573 0.9634 9.0469, 72.27 0.55
BXD55 m 19.196 5.3757   5 2.4041 0.28 10.695, 24.655 -0.29
BXD6 m 20.461 4.4525   5 1.9912 0.2176 14.876, 26.55 -0.15
BXD62 m 21.708 10.664   5 4.7692 0.4913 13.749, 40.325 -0.02
BXD63 m 20.891 7.5674   5 3.3843 0.3622 13.098, 30.967 -0.11
BXD64 m 17.029 7.3143   3 4.2229 0.4295 9.9611, 24.567 -0.53
BXD66 m 24.524 7.1259   7 2.6933 0.2906 13.502, 35.492 0.3
BXD67 m 13.74 9.4385   4 4.7192 0.687 7.1498, 27.703 -0.9
BXD69 m 24.375 10.143   5 4.5359 0.4161 13.288, 38.913 0.28
BXD73 m 16.82 5.8115   5 2.599 0.3455 10.987, 25.609 -0.56
BXD75 m 11.435 2.5204   5 1.1272 0.2204 7.2201, 13.38 -1.15
BXD77 m 17.08 7.2264   5 3.2317 0.4231 9.77, 27.218 -0.53
BXD79 m 54.72 19.663   5 8.7934 0.3593 24.2, 76.45 3.63
BXD8 m 10.863 1.7926   5 0.80169 0.165 8.9734, 13.784 -1.21
BXD81 m 18.775 5.8686   4 2.9343 0.3126 10.222, 23.578 -0.34
BXD84 m 17.068 4.785   5 2.1399 0.2803 10.731, 22.595 -0.53
BXD87 m 48.677 8.7151   5 3.8975 0.179 36.198, 57.53 2.97
BXD89 m 20.011 6.8127   5 3.0467 0.3404 12.011, 28.308 -0.2
BXD90 m 23.654 8.6805   5 3.882 0.367 9.1071, 31.861 0.2
C57BL/6J m 22.151 2.6347   5 1.1783 0.1189 18.866, 25.884 0.03
DBA/2J m 12.369 2.7131   5 1.2133 0.2193 8.5446, 16.189 -1.05


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 26.24075 4.8533369211 35.8398047752 16.6416952248
BXD100 m 21.8938333333 3.9627330022 29.7314287374 14.0562379293
BXD11 m 18.55705 4.8533369211 28.1561047752 8.9579952248
BXD12 m 22.0675 4.8533369211 31.6665547752 12.4684452248
BXD27 m 24.26625 4.8533369211 33.8653047752 14.6671952248
BXD32 m 20.254 4.3409565093 28.8396555988 11.6683444012
BXD34 m 16.2222 4.3409565093 24.8078555988 7.6365444012
BXD39 m 22.3438 4.3409565093 30.9294555988 13.7581444012
BXD40 m 15.50562 4.3409565093 24.0912755988 6.9199644012
BXD43 m 21.8273333333 5.6041507557 32.9113670502 10.7432996165
BXD45 m 17.1045 4.8533369211 26.7035547752 7.5054452248
BXD48 m 33.893 4.3409565093 42.4786555988 25.3073444012
BXD48a m 16.6085 4.8533369211 26.2075547752 7.0094452248
BXD49 m 13.505325 4.8533369211 23.1043797752 3.9062702248
BXD51 m 33.8588 4.3409565093 42.4444555988 25.2731444012
BXD53 m 26.86138 4.3409565093 35.4470355988 18.2757244012
BXD55 m 19.196 4.3409565093 27.7816555988 10.6103444012
BXD6 m 20.4614 4.3409565093 29.0470555988 11.8757444012
BXD62 m 21.7082 4.3409565093 30.2938555988 13.1225444012
BXD63 m 20.8912 4.3409565093 29.4768555988 12.3055444012
BXD64 m 17.0293666667 5.6041507557 28.1134003835 5.9453329498
BXD66 m 24.5241428571 3.6687778634 31.7803462161 17.2679394982
BXD67 m 13.739675 4.8533369211 23.3387297752 4.1406202248
BXD69 m 24.3754 4.3409565093 32.9610555988 15.7897444012
BXD73 m 16.82 4.3409565093 25.4056555988 8.2343444012
BXD75 m 11.43542 4.3409565093 20.0210755988 2.8497644012
BXD77 m 17.0796 4.3409565093 25.6652555988 8.4939444012
BXD79 m 54.72 4.3409565093 63.3056555988 46.1343444012
BXD8 m 10.86288 4.3409565093 19.4485355988 2.2772244012
BXD81 m 18.7745 4.8533369211 28.3735547752 9.1754452248
BXD84 m 17.0682 4.3409565093 25.6538555988 8.4825444012
BXD87 m 48.6768 4.3409565093 57.2624555988 40.0911444012
BXD89 m 20.011 4.3409565093 28.5966555988 11.4253444012
BXD90 m 23.65402 4.3409565093 32.2396755988 15.0683644012
C57BL/6J m 22.1512 4.3409565093 30.7368555988 13.5655444012
DBA/2J m 12.36912 4.3409565093 20.9547755988 3.7834644012




  GWAS USING LINEAR MIXED MODELS