Project measure / variable:   Schoonjans1   TbMCA_liver_HFD

ID, description, units MPD:112838   TbMCA_liver_HFD   bile acid tauro-β-muricholic acid amount in liver, at 29 wks   [ng/mL]  HFD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 29wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid tauro-β-muricholic acid amount in liver, at 29 wks HFD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means30.973   ng/mL
Median of the strain means25.524   ng/mL
SD of the strain means± 16.613
Coefficient of variation (CV)0.5364
Min–max range of strain means9.9643   –   79.09   ng/mL
Mean sample size per strain4.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 45178.6388 1290.8183 3.1083 < 0.0001
Residuals 141 58554.294 415.2787


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 44.992 19.853   5 8.8784 0.4413 29.322, 72.82 0.84
BXD100 m 47.823 68.33   7 25.825 1.4287 6.7072, 200.1 1.01
BXD11 m 24.276 16.985   3 9.8064 0.6997 11.774, 43.614 -0.4
BXD12 m 30.77 22.545   4 11.272 0.7327 12.115, 63.58 -0.01
BXD27 m 53.78 21.886   5 9.7877 0.407 35.944, 87.58 1.37
BXD32 m 54.81 25.103   4 12.551 0.458 31.599, 90.49 1.43
BXD34 m 79.09 37.905   4 18.953 0.4792 53.83, 135.5 2.9
BXD39 m 29.62 13.346   5 5.9685 0.4506 15.839, 49.384 -0.08
BXD40 m 34.39 15.089   5 6.7479 0.4387 17.769, 58.54 0.21
BXD43 m 33.731 15.814   5 7.0724 0.4688 16.617, 56.8 0.17
BXD45 m 57.86 11.751   5 5.2553 0.2031 42.723, 71.56 1.62
BXD48 m 13.647 3.7536   5 1.6787 0.275 8.0195, 18.161 -1.04
BXD48a m 22.909 11.168   5 4.9946 0.4875 11.969, 40.999 -0.49
BXD49 m 31.166 15.032   5 6.7225 0.4823 14.668, 47.953 0.01
BXD51 m 31.049 9.7479   5 4.3594 0.314 20.999, 47.186 0.0
BXD53 m 20.467 4.5013   5 2.0131 0.2199 13.701, 25.003 -0.63
BXD55 m 15.138 11.758   5 5.2585 0.7767 5.4058, 34.237 -0.95
BXD6 m 22.869 2.5818   5 1.1546 0.1129 20.06, 25.887 -0.49
BXD62 m 27.71 14.582   5 6.5214 0.5263 9.1856, 47.852 -0.2
BXD63 m 23.822 7.5795   5 3.3896 0.3182 15.484, 31.474 -0.43
BXD64 m 24.346 10.751   5 4.8079 0.4416 12.281, 35.708 -0.4
BXD66 m 17.664 11.497   9 3.8324 0.6509 5.1188, 41.558 -0.8
BXD67 m 21.758 5.4312   5 2.4289 0.2496 12.974, 26.833 -0.55
BXD69 m 13.657 12.865   5 5.7535 0.9421 4.3721, 35.898 -1.04
BXD73 m 18.188 5.261   5 2.3528 0.2893 11.264, 23.899 -0.77
BXD75 m 25.587 11.628   4 5.814 0.4545 15.027, 41.552 -0.32
BXD77 m 25.462 11.47   5 5.1297 0.4505 11.994, 41.803 -0.33
BXD79 m 21.613 16.738   5 7.4855 0.7744 8.1325, 50.77 -0.56
BXD8 m 62.5 28.292   4 14.146 0.4527 28.165, 97.23 1.9
BXD81 m 9.9643 2.2713   5 1.0158 0.2279 6.9887, 13.325 -1.26
BXD84 m 14.292 5.1312   5 2.2948 0.359 9.2798, 22.091 -1.0
BXD87 m 65.25 27.141   5 12.138 0.416 29.262, 90.92 2.06
BXD89 m 29.873 16.909   5 7.5619 0.566 16.336, 58.3 -0.07
BXD90 m 17.468 7.4101   3 4.2782 0.4242 12.884, 26.017 -0.81
C57BL/6J m 28.184 12.103   5 5.4125 0.4294 11.391, 43.874 -0.17
DBA/2J m 19.292 7.3541   5 3.2889 0.3812 8.4185, 28.679 -0.7


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 44.9916 9.1134919872 63.0083492808 26.9748507192
BXD100 m 47.8226 7.7023065284 63.0495323111 32.5956676889
BXD11 m 24.276 11.765467564 47.5355233058 1.0164766942
BXD12 m 30.7705 10.1891937978 50.9138380627 10.6271619373
BXD27 m 53.7766 9.1134919872 71.7933492808 35.7598507192
BXD32 m 54.81375 10.1891937978 74.9570880627 34.6704119373
BXD34 m 79.0925 10.1891937978 99.2358380627 58.9491619373
BXD39 m 29.6198 9.1134919872 47.6365492808 11.6030507192
BXD40 m 34.3902 9.1134919872 52.4069492808 16.3734507192
BXD43 m 33.7306 9.1134919872 51.7473492808 15.7138507192
BXD45 m 57.8592 9.1134919872 75.8759492808 39.8424507192
BXD48 m 13.6471 9.1134919872 31.6638492808 -4.3696492808
BXD48a m 22.9086 9.1134919872 40.9253492808 4.8918507192
BXD49 m 31.1658 9.1134919872 49.1825492808 13.1490507192
BXD51 m 31.0492 9.1134919872 49.0659492808 13.0324507192
BXD53 m 20.4666 9.1134919872 38.4833492808 2.4498507192
BXD55 m 15.13822 9.1134919872 33.1549692808 -2.8785292808
BXD6 m 22.8686 9.1134919872 40.8853492808 4.8518507192
BXD62 m 27.70992 9.1134919872 45.7266692808 9.6931707192
BXD63 m 23.8224 9.1134919872 41.8391492808 5.8056507192
BXD64 m 24.3464 9.1134919872 42.3631492808 6.3296507192
BXD66 m 17.6635555556 6.7927958652 31.0924475974 4.2346635137
BXD67 m 21.7578 9.1134919872 39.7745492808 3.7410507192
BXD69 m 13.65662 9.1134919872 31.6733692808 -4.3601292808
BXD73 m 18.1876 9.1134919872 36.2043492808 0.1708507192
BXD75 m 25.58675 10.1891937978 45.7300880627 5.4434119373
BXD77 m 25.4624 9.1134919872 43.4791492808 7.4456507192
BXD79 m 21.6133 9.1134919872 39.6300492808 3.5965507192
BXD8 m 62.50125 10.1891937978 82.6445880627 42.3579119373
BXD81 m 9.96432 9.1134919872 27.9810692808 -8.0524292808
BXD84 m 14.29176 9.1134919872 32.3085092808 -3.7249892808
BXD87 m 65.2466 9.1134919872 83.2633492808 47.2298507192
BXD89 m 29.8728 9.1134919872 47.8895492808 11.8560507192
BXD90 m 17.468 11.765467564 40.7275233058 -5.7915233058
C57BL/6J m 28.1842 9.1134919872 46.2009492808 10.1674507192
DBA/2J m 19.2923 9.1134919872 37.3090492808 1.2755507192




  GWAS USING LINEAR MIXED MODELS