Project measure / variable:   Schoonjans1   TbMCA_liver_CD

ID, description, units MPD:112837   TbMCA_liver_CD   bile acid tauro-β-muricholic acid amount in liver, at 29 wks   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 29wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid tauro-β-muricholic acid amount in liver, at 29 wks CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means17.599   ng/mL
Median of the strain means14.931   ng/mL
SD of the strain means± 7.6658
Coefficient of variation (CV)0.4356
Min–max range of strain means6.6101   –   42.884   ng/mL
Mean sample size per strain4.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 9471.0522 270.6015 4.0963 < 0.0001
Residuals 134 8852.0107 66.0598


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 14.285 3.2046   4 1.6023 0.2243 10.67, 18.137 -0.43
BXD100 m 13.6 2.7095   6 1.1061 0.1992 9.7553, 17.675 -0.52
BXD11 m 20.151 10.895   4 5.4473 0.5406 6.4873, 30.345 0.33
BXD12 m 22.426 11.154   4 5.5768 0.4973 12.416, 38.398 0.63
BXD27 m 42.884 16.801   4 8.4005 0.3918 24.426, 63.06 3.3
BXD32 m 13.403 4.9554   5 2.2161 0.3697 6.5281, 18.555 -0.55
BXD34 m 14.192 2.0777   5 0.92916 0.1464 11.552, 16.717 -0.44
BXD39 m 23.879 8.6696   5 3.8772 0.3631 11.751, 35.262 0.82
BXD40 m 13.878 6.8379   5 3.058 0.4927 4.9116, 22.311 -0.49
BXD43 m 20.662 6.6523   3 3.8407 0.322 13.297, 26.234 0.4
BXD45 m 15.175 4.4069   4 2.2034 0.2904 9.0777, 19.512 -0.32
BXD48 m 11.808 7.94   5 3.5509 0.6724 5.5022, 24.828 -0.76
BXD48a m 9.9716 6.9212   4 3.4606 0.6941 2.6689, 17.789 -0.99
BXD49 m 7.4505 3.1678   4 1.5839 0.4252 3.0125, 10.407 -1.32
BXD51 m 20.148 5.3949   5 2.4127 0.2678 16.521, 29.515 0.33
BXD53 m 17.867 12.693   5 5.6767 0.7104 8.7578, 39.961 0.03
BXD55 m 10.091 3.185   5 1.4244 0.3156 5.1388, 13.282 -0.98
BXD6 m 21.299 3.2514   5 1.4541 0.1527 16.693, 25.811 0.48
BXD62 m 32.054 16.228   5 7.2576 0.5063 14.504, 55.88 1.89
BXD63 m 13.633 5.8696   5 2.625 0.4306 7.3175, 20.405 -0.52
BXD64 m 16.911 7.1639   3 4.1361 0.4236 11.302, 24.981 -0.09
BXD66 m 26.211 8.9074   7 3.3667 0.3398 13.077, 35.816 1.12
BXD67 m 27.165 24.59   4 12.295 0.9052 11.876, 63.63 1.25
BXD69 m 14.266 4.9282   5 2.204 0.3455 6.9275, 20.816 -0.43
BXD73 m 8.6714 3.6453   5 1.6302 0.4204 5.5959, 14.59 -1.16
BXD75 m 6.6101 2.1312   5 0.95312 0.3224 3.3713, 9.0828 -1.43
BXD77 m 13.629 5.2471   5 2.3466 0.385 7.22, 21.016 -0.52
BXD79 m 29.669 9.7111   5 4.3429 0.3273 15.028, 39.611 1.57
BXD8 m 18.567 5.1902   5 2.3211 0.2795 12.571, 24.633 0.13
BXD81 m 13.305 3.6086   4 1.8043 0.2712 8.628, 16.986 -0.56
BXD84 m 15.266 4.8548   5 2.1711 0.318 8.3033, 19.994 -0.3
BXD87 m 27.889 9.1088   5 4.0736 0.3266 16.451, 38.53 1.34
BXD89 m 19.026 6.1616   5 2.7556 0.3238 11.342, 25.185 0.19
BXD90 m 14.688 5.4995   5 2.4595 0.3744 7.2573, 21.38 -0.38
C57BL/6J m 13.642 4.0734   5 1.8217 0.2986 9.552, 19.73 -0.52
DBA/2J m 9.1818 3.033   5 1.3564 0.3303 4.3638, 11.937 -1.1


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 14.2845 4.0638584276 22.3221038754 6.2468961246
BXD100 m 13.60005 3.3181265115 20.1627260831 7.0373739169
BXD11 m 20.151325 4.0638584276 28.1889288754 12.1137211246
BXD12 m 22.4265 4.0638584276 30.4641038754 14.3888961246
BXD27 m 42.88375 4.0638584276 50.9213538754 34.8461461246
BXD32 m 13.40262 3.634825478 20.5916714566 6.2135685434
BXD34 m 14.1916 3.634825478 21.3806514566 7.0025485434
BXD39 m 23.8788 3.634825478 31.0678514566 16.6897485434
BXD40 m 13.87752 3.634825478 21.0665714566 6.6884685434
BXD43 m 20.662 4.6925395143 29.9430255222 11.3809744778
BXD45 m 15.174675 4.0638584276 23.2122788754 7.1370711246
BXD48 m 11.80774 3.634825478 18.9967914566 4.6186885434
BXD48a m 9.9716 4.0638584276 18.0092038754 1.9339961246
BXD49 m 7.45055 4.0638584276 15.4881538754 -0.5870538754
BXD51 m 20.1482 3.634825478 27.3372514566 12.9591485434
BXD53 m 17.86696 3.634825478 25.0560114566 10.6779085434
BXD55 m 10.09078 3.634825478 17.2798314566 2.9017285434
BXD6 m 21.2986 3.634825478 28.4876514566 14.1095485434
BXD62 m 32.0536 3.634825478 39.2426514566 24.8645485434
BXD63 m 13.63276 3.634825478 20.8218114566 6.4437085434
BXD64 m 16.911 4.6925395143 26.1920255222 7.6299744778
BXD66 m 26.2107142857 3.071988218 32.2865717117 20.1348568597
BXD67 m 27.16525 4.0638584276 35.2028538754 19.1276461246
BXD69 m 14.2659 3.634825478 21.4549514566 7.0768485434
BXD73 m 8.67138 3.634825478 15.8604314566 1.4823285434
BXD75 m 6.6101 3.634825478 13.7991514566 -0.5789514566
BXD77 m 13.6294 3.634825478 20.8184514566 6.4403485434
BXD79 m 29.6692 3.634825478 36.8582514566 22.4801485434
BXD8 m 18.5668 3.634825478 25.7558514566 11.3777485434
BXD81 m 13.305 4.0638584276 21.3426038754 5.2673961246
BXD84 m 15.26626 3.634825478 22.4553114566 8.0772085434
BXD87 m 27.8886 3.634825478 35.0776514566 20.6995485434
BXD89 m 19.0264 3.634825478 26.2154514566 11.8373485434
BXD90 m 14.68806 3.634825478 21.8771114566 7.4990085434
C57BL/6J m 13.6422 3.634825478 20.8312514566 6.4531485434
DBA/2J m 9.18182 3.634825478 16.3708714566 1.9927685434




  GWAS USING LINEAR MIXED MODELS