Project measure / variable:   Schoonjans1   TaMCA_liver_CD

ID, description, units MPD:112835   TaMCA_liver_CD   bile acid tauro-α-muricholic acid amount in liver, at 29 wks   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 29wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid tauro-α-muricholic acid amount in liver, at 29 wks CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means5.4497   ng/mL
Median of the strain means5.1485   ng/mL
SD of the strain means± 1.7327
Coefficient of variation (CV)0.3179
Min–max range of strain means3.2444   –   10.234   ng/mL
Mean sample size per strain4.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 469.4658 13.4133 3.4658 < 0.0001
Residuals 134 518.6061 3.8702


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 4.0741 0.76117   4 0.38059 0.1868 3.3726, 5.0175 -0.79
BXD100 m 4.6755 0.47998   6 0.19595 0.1027 4.0659, 5.3885 -0.45
BXD11 m 6.18 2.6762   4 1.3381 0.433 2.7712, 8.3478 0.42
BXD12 m 10.234 2.0664   4 1.0332 0.2019 8.5998, 13.261 2.76
BXD27 m 8.705 2.1542   4 1.0771 0.2475 6.2283, 10.561 1.88
BXD32 m 3.8047 1.5184   5 0.67903 0.3991 2.4172, 5.7452 -0.95
BXD34 m 5.4426 0.83994   5 0.37563 0.1543 4.535, 6.4656 0.0
BXD39 m 4.9611 1.1208   5 0.50123 0.2259 3.8329, 6.8137 -0.28
BXD40 m 4.4526 1.8108   5 0.80983 0.4067 2.2452, 6.3744 -0.58
BXD43 m 3.7174 2.2063   3 1.2738 0.5935 1.682, 6.062 -1.0
BXD45 m 7.3508 2.125   4 1.0625 0.2891 4.2542, 8.8674 1.1
BXD48 m 7.1287 5.0512   5 2.259 0.7086 2.7578, 15.459 0.97
BXD48a m 5.0044 2.2564   4 1.1282 0.4509 2.3322, 7.2293 -0.26
BXD49 m 3.8954 2.0571   4 1.0285 0.5281 1.742, 6.5706 -0.9
BXD51 m 5.4281 1.3604   5 0.60838 0.2506 4.0747, 7.2821 -0.01
BXD53 m 5.3047 2.1068   5 0.9422 0.3972 2.63, 7.8669 -0.08
BXD55 m 5.5955 1.4168   5 0.6336 0.2532 3.2869, 6.7182 0.08
BXD6 m 3.9039 0.85301   5 0.38148 0.2185 2.9313, 5.2149 -0.89
BXD62 m 5.2925 2.3447   5 1.0486 0.443 3.6929, 9.2828 -0.09
BXD63 m 3.5521 1.4454   5 0.64642 0.4069 2.3167, 5.735 -1.1
BXD64 m 6.6925 3.3232   3 1.9187 0.4966 4.3218, 10.491 0.72
BXD66 m 6.1004 2.0899   7 0.78992 0.3426 2.841, 8.1537 0.38
BXD67 m 3.3689 1.0159   4 0.50795 0.3016 2.2801, 4.4526 -1.2
BXD69 m 7.6881 2.6504   5 1.1853 0.3447 4.0237, 10.909 1.29
BXD73 m 4.2502 1.1836   5 0.52932 0.2785 2.7151, 5.6255 -0.69
BXD75 m 3.2444 0.89999   5 0.40249 0.2774 1.9738, 4.3924 -1.27
BXD77 m 6.8911 2.4725   5 1.1057 0.3588 4.0698, 10.545 0.83
BXD79 m 8.6994 2.4396   5 1.091 0.2804 5.4791, 11.286 1.88
BXD8 m 3.7323 0.68765   5 0.30752 0.1842 3.0759, 4.8409 -0.99
BXD81 m 4.1221 1.6172   4 0.8086 0.3923 2.1427, 5.7591 -0.77
BXD84 m 4.3018 1.3425   5 0.60041 0.3121 2.8093, 6.4205 -0.66
BXD87 m 6.0195 1.2567   5 0.56203 0.2088 4.3214, 7.6147 0.33
BXD89 m 6.9538 2.0699   5 0.92569 0.2977 4.3094, 9.8322 0.87
BXD90 m 7.2442 2.9804   5 1.3329 0.4114 2.4954, 10.015 1.04
C57BL/6J m 4.6933 0.73851   5 0.33027 0.1574 3.7391, 5.4812 -0.44
DBA/2J m 3.4846 0.84416   5 0.37752 0.2423 2.4681, 4.5131 -1.13


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 4.07415 0.9836405193 6.0196195558 2.1286804442
BXD100 m 4.6755 0.8031391209 6.2639692406 3.0870307594
BXD11 m 6.18 0.9836405193 8.1254695558 4.2345304442
BXD12 m 10.233975 0.9836405193 12.1794445558 8.2885054442
BXD27 m 8.705025 0.9836405193 10.6504945558 6.7595554442
BXD32 m 3.80474 0.8797948267 5.54482087 2.06465913
BXD34 m 5.44262 0.8797948267 7.18270087 3.70253913
BXD39 m 4.96106 0.8797948267 6.70114087 3.22097913
BXD40 m 4.45264 0.8797948267 6.19272087 2.71255913
BXD43 m 3.7174333333 1.1358102372 5.9638680768 1.4709985898
BXD45 m 7.3508 0.9836405193 9.2962695558 5.4053304442
BXD48 m 7.12872 0.8797948267 8.86880087 5.38863913
BXD48a m 5.004425 0.9836405193 6.9498945558 3.0589554442
BXD49 m 3.8954 0.9836405193 5.8408695558 1.9499304442
BXD51 m 5.42806 0.8797948267 7.16814087 3.68797913
BXD53 m 5.3047 0.8797948267 7.04478087 3.56461913
BXD55 m 5.59548 0.8797948267 7.33556087 3.85539913
BXD6 m 3.90392 0.8797948267 5.64400087 2.16383913
BXD62 m 5.2925 0.8797948267 7.03258087 3.55241913
BXD63 m 3.55214 0.8797948267 5.29222087 1.81205913
BXD64 m 6.6925 1.1358102372 8.9389347435 4.4460652565
BXD66 m 6.1004 0.743562341 7.5710367508 4.6297632492
BXD67 m 3.3689 0.9836405193 5.3143695558 1.4234304442
BXD69 m 7.68814 0.8797948267 9.42822087 5.94805913
BXD73 m 4.25016 0.8797948267 5.99024087 2.51007913
BXD75 m 3.24442 0.8797948267 4.98450087 1.50433913
BXD77 m 6.89106 0.8797948267 8.63114087 5.15097913
BXD79 m 8.69942 0.8797948267 10.43950087 6.95933913
BXD8 m 3.73226 0.8797948267 5.47234087 1.99217913
BXD81 m 4.122125 0.9836405193 6.0675945558 2.1766554442
BXD84 m 4.3018 0.8797948267 6.04188087 2.56171913
BXD87 m 6.01952 0.8797948267 7.75960087 4.27943913
BXD89 m 6.9538 0.8797948267 8.69388087 5.21371913
BXD90 m 7.24418 0.8797948267 8.98426087 5.50409913
C57BL/6J m 4.69334 0.8797948267 6.43342087 2.95325913
DBA/2J m 3.4846 0.8797948267 5.22468087 1.74451913




  GWAS USING LINEAR MIXED MODELS