Project measure / variable:   Schoonjans1   wMCA_feces_CD

ID, description, units MPD:112806   wMCA_feces_CD   bile acid ω-muricholic acid in feces, at 24 wks   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 24wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid ω-muricholic acid in feces, at 24 wks CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means23.591   ng/mL
Median of the strain means23.131   ng/mL
SD of the strain means± 7.4895
Coefficient of variation (CV)0.3175
Min–max range of strain means11.473   –   40.768   ng/mL
Mean sample size per strain4.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 10096.4343 288.4696 5.7217 < 0.0001
Residuals 139 7007.9483 50.4169


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 17.895 4.3219   5 1.9328 0.2415 11.31, 21.79 -0.76
BXD100 m 23.603 3.9612   5 1.7715 0.1678 19.4, 29.626 0.0
BXD11 m 23.38 10.841   4 5.4206 0.4637 12.331, 38.163 -0.03
BXD12 m 20.128 7.9953   4 3.9976 0.3972 14.54, 31.984 -0.46
BXD27 m 18.057 4.9672   4 2.4836 0.2751 11.682, 22.44 -0.74
BXD32 m 17.819 2.4501   4 1.225 0.1375 15.745, 20.845 -0.77
BXD34 m 15.401 4.0191   4 2.0095 0.261 10.001, 19.03 -1.09
BXD39 m 16.171 5.5442   5 2.4795 0.3429 7.7199, 21.115 -0.99
BXD40 m 15.998 2.906   5 1.2996 0.1816 13.461, 20.776 -1.01
BXD43 m 26.217 9.6772   4 4.8386 0.3691 13.345, 34.849 0.35
BXD45 m 17.757 5.1625   3 2.9806 0.2907 13.151, 23.337 -0.78
BXD48 m 24.655 10.295   5 4.6042 0.4176 14.973, 37.21 0.14
BXD48a m 33.24 6.8942   4 3.4471 0.2074 27.996, 43.211 1.29
BXD49 m 21.161 6.4637   5 2.8907 0.3055 14.013, 30.005 -0.32
BXD51 m 26.812 3.2396   5 1.4488 0.1208 22.904, 31.523 0.43
BXD53 m 11.473 3.9026   5 1.7453 0.3401 6.1919, 15.844 -1.62
BXD55 m 16.418 2.8771   5 1.2867 0.1752 12.078, 19.379 -0.96
BXD6 m 18.325 4.5101   5 2.017 0.2461 13.261, 23.45 -0.7
BXD62 m 14.097 4.686   5 2.0957 0.3324 6.1902, 18.225 -1.27
BXD63 m 30.855 11.083   5 4.9565 0.3592 18.067, 44.58 0.97
BXD64 m 22.925 2.4027   5 1.0745 0.1048 19.365, 25.524 -0.09
BXD66 m 40.768 7.1508   5 3.1979 0.1754 34.284, 50.86 2.29
BXD67 m 23.337 4.8786   4 2.4393 0.2091 17.879, 28.55 -0.03
BXD69 m 31.585 9.4039   5 4.2056 0.2977 20.277, 41.691 1.07
BXD73 m 18.919 4.3721   5 1.9553 0.2311 12.475, 22.833 -0.62
BXD75 m 34.517 8.3518   5 3.7351 0.242 28.08, 47.577 1.46
BXD77 m 37.649 10.942   5 4.8934 0.2906 23.848, 51.71 1.88
BXD79 m 25.66 4.73   5 2.1153 0.1843 18.874, 30.176 0.28
BXD8 m 22.067 7.6798   5 3.4345 0.348 12.546, 31.229 -0.2
BXD81 m 29.039 12.179   5 5.4466 0.4194 14.13, 42.916 0.73
BXD84 m 28.675 10.345   5 4.6263 0.3608 20.333, 45.443 0.68
BXD87 m 17.813 3.4494   5 1.5426 0.1936 13.624, 23.059 -0.77
BXD89 m 36.152 9.3561   5 4.1842 0.2588 25.001, 50.05 1.68
BXD90 m 32.532 10.996   5 4.9178 0.338 20.305, 47.941 1.19
C57BL/6J m 12.662 2.7904   10 0.8824 0.2204 6.8806, 16.813 -1.46
DBA/2J m 25.516 9.7335   5 4.353 0.3815 13.215, 35.301 0.26


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 17.895 3.1754336466 24.1733966716 11.6166033284
BXD100 m 23.6032 3.1754336466 29.8815966716 17.3248033284
BXD11 m 23.38025 3.5502427459 30.3997108737 16.3607891263
BXD12 m 20.12775 3.5502427459 27.1472108737 13.1082891263
BXD27 m 18.05675 3.5502427459 25.0762108737 11.0372891263
BXD32 m 17.81925 3.5502427459 24.8387108737 10.7997891263
BXD34 m 15.4015 3.5502427459 22.4209608737 8.3820391263
BXD39 m 16.17098 3.1754336466 22.4493766716 9.8925833284
BXD40 m 15.9982 3.1754336466 22.2765966716 9.7198033284
BXD43 m 26.21725 3.5502427459 33.2367108737 19.1977891263
BXD45 m 17.7566666667 4.0994672101 25.8620419167 9.6512914167
BXD48 m 24.6554 3.1754336466 30.9337966716 18.3770033284
BXD48a m 33.24025 3.5502427459 40.2597108737 26.2207891263
BXD49 m 21.1612 3.1754336466 27.4395966716 14.8828033284
BXD51 m 26.812 3.1754336466 33.0903966716 20.5336033284
BXD53 m 11.4732 3.1754336466 17.7515966716 5.1948033284
BXD55 m 16.4178 3.1754336466 22.6961966716 10.1394033284
BXD6 m 18.3254 3.1754336466 24.6037966716 12.0470033284
BXD62 m 14.09684 3.1754336466 20.3752366716 7.8184433284
BXD63 m 30.855 3.1754336466 37.1333966716 24.5766033284
BXD64 m 22.925 3.1754336466 29.2033966716 16.6466033284
BXD66 m 40.7676 3.1754336466 47.0459966716 34.4892033284
BXD67 m 23.33675 3.5502427459 30.3562108737 16.3172891263
BXD69 m 31.5852 3.1754336466 37.8635966716 25.3068033284
BXD73 m 18.9194 3.1754336466 25.1977966716 12.6410033284
BXD75 m 34.517 3.1754336466 40.7953966716 28.2386033284
BXD77 m 37.6488 3.1754336466 43.9271966716 31.3704033284
BXD79 m 25.6602 3.1754336466 31.9385966716 19.3818033284
BXD8 m 22.0666 3.1754336466 28.3449966716 15.7882033284
BXD81 m 29.0388 3.1754336466 35.3171966716 22.7604033284
BXD84 m 28.6752 3.1754336466 34.9535966716 22.3968033284
BXD87 m 17.813 3.1754336466 24.0913966716 11.5346033284
BXD89 m 36.1516 3.1754336466 42.4299966716 29.8732033284
BXD90 m 32.5316 3.1754336466 38.8099966716 26.2532033284
C57BL/6J m 12.66166 2.2453706647 17.1011568615 8.2221631385
DBA/2J m 25.5156 3.1754336466 31.7939966716 19.2372033284




  GWAS USING LINEAR MIXED MODELS