Project measure / variable:   Schoonjans1   CDCA_feces_CD

ID, description, units MPD:112766   CDCA_feces_CD   bile acid chenodeoxycholic acid amount in feces, at 24 wks   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 24wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid chenodeoxycholic acid amount in feces, at 24 wks CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means0.835   ng/mL
Median of the strain means0.21266   ng/mL
SD of the strain means± 3.5036
Coefficient of variation (CV)4.196
Min–max range of strain means0.05053   –   21.251   ng/mL
Mean sample size per strain4.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 4161.1626 118.8904 0.4118 0.9985
Residuals 139 40133.3785 288.7293


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 0.10722 0.02824   5 0.01263 0.2633 0.07602, 0.14556 -0.21
BXD100 m 0.78116 0.14096   5 0.06304 0.1805 0.58309, 0.97436 -0.02
BXD11 m 0.29484 0.1106   4 0.0553 0.3751 0.16604, 0.43101 -0.15
BXD12 m 0.19925 0.06751   4 0.03376 0.3388 0.10138, 0.25631 -0.18
BXD27 m 0.21665 0.1127   4 0.05635 0.5202 0.13178, 0.3826 -0.18
BXD32 m 0.22965 0.04865   4 0.02433 0.2119 0.18765, 0.29743 -0.17
BXD34 m 0.13894 0.06146   4 0.03073 0.4424 0.08198, 0.2152 -0.2
BXD39 m 0.15431 0.08867   5 0.03965 0.5746 0.08861, 0.27181 -0.19
BXD40 m 0.16831 0.04282   5 0.01915 0.2544 0.12503, 0.22598 -0.19
BXD43 m 0.13793 0.02975   4 0.01487 0.2157 0.09566, 0.16194 -0.2
BXD45 m 0.12855 0.06096   3 0.03519 0.4742 0.07388, 0.19428 -0.2
BXD48 m 0.26143 0.20742   5 0.09276 0.7934 0.12713, 0.62282 -0.16
BXD48a m 0.35932 0.17494   4 0.08747 0.4869 0.1878, 0.60266 -0.14
BXD49 m 0.08294 0.01585   5 0.00708988 0.1911 0.06019, 0.09922 -0.21
BXD51 m 0.36232 0.08468   5 0.03787 0.2337 0.26186, 0.47173 -0.13
BXD53 m 0.05053 0.01445   5 0.00646113 0.2859 0.0339, 0.06976 -0.22
BXD55 m 0.17753 0.05578   5 0.02495 0.3142 0.11079, 0.23885 -0.19
BXD6 m 0.22698 0.03612   5 0.01615 0.1591 0.18254, 0.26526 -0.17
BXD62 m 0.37117 0.10015   5 0.04479 0.2698 0.23939, 0.52064 -0.13
BXD63 m 0.1269 0.04377   5 0.01957 0.3449 0.07448, 0.17955 -0.2
BXD64 m 0.27598 0.06259   5 0.02799 0.2268 0.19714, 0.33468 -0.16
BXD66 m 0.35678 0.06146   5 0.02749 0.1723 0.29577, 0.44215 -0.14
BXD67 m 0.20866 0.03031   4 0.01515 0.1452 0.16637, 0.23655 -0.18
BXD69 m 0.22114 0.05585   5 0.02498 0.2525 0.15996, 0.30519 -0.18
BXD73 m 0.12014 0.05811   5 0.02599 0.4837 0.04521, 0.18455 -0.2
BXD75 m 0.27631 0.15855   5 0.0709 0.5738 0.164, 0.51982 -0.16
BXD77 m 0.43518 0.11024   5 0.0493 0.2533 0.30737, 0.60786 -0.11
BXD79 m 0.19309 0.07404   5 0.03311 0.3834 0.08049, 0.2859 -0.18
BXD8 m 0.1075 0.02833   5 0.01267 0.2636 0.06237, 0.13675 -0.21
BXD81 m 0.17083 0.05688   5 0.02544 0.3329 0.07358, 0.21375 -0.19
BXD84 m 0.11876 0.01369   5 0.0061211 0.1153 0.09873, 0.1356 -0.2
BXD87 m 0.13368 0.03315   5 0.01482 0.248 0.08768, 0.16797 -0.2
BXD89 m 0.46005 0.19284   5 0.08624 0.4192 0.25894, 0.65464 -0.11
BXD90 m 0.72666 0.34787   5 0.15557 0.4787 0.45417, 1.3102 -0.03
C57BL/6J m 21.251 66.78   10 21.117 3.1423 0.06997, 211.3 5.83
DBA/2J m 0.4283 0.17199   5 0.07692 0.4016 0.24377, 0.65039 -0.12


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 0.107222 7.5990702277 15.1319343811 -14.9174903811
BXD100 m 0.781158 7.5990702277 15.8058703811 -14.2435543811
BXD11 m 0.2948425 8.4960187975 17.0929816132 -16.5032966132
BXD12 m 0.199245 8.4960187975 16.9973841132 -16.5988941132
BXD27 m 0.216645 8.4960187975 17.0147841132 -16.5814941132
BXD32 m 0.2296475 8.4960187975 17.0277866132 -16.5684916132
BXD34 m 0.1389425 8.4960187975 16.9370816132 -16.6591966132
BXD39 m 0.154306 7.5990702277 15.1790183811 -14.8704063811
BXD40 m 0.16831 7.5990702277 15.1930223811 -14.8564023811
BXD43 m 0.13793 8.4960187975 16.9360691132 -16.6602091132
BXD45 m 0.1285533333 9.8103574795 19.5253736112 -19.2682669445
BXD48 m 0.261434 7.5990702277 15.2861463811 -14.7632783811
BXD48a m 0.359325 8.4960187975 17.1574641132 -16.4388141132
BXD49 m 0.082942 7.5990702277 15.1076543811 -14.9417703811
BXD51 m 0.362318 7.5990702277 15.3870303811 -14.6623943811
BXD53 m 0.050532 7.5990702277 15.0752443811 -14.9741803811
BXD55 m 0.177526 7.5990702277 15.2022383811 -14.8471863811
BXD6 m 0.22698 7.5990702277 15.2516923811 -14.7977323811
BXD62 m 0.37117 7.5990702277 15.3958823811 -14.6535423811
BXD63 m 0.126904 7.5990702277 15.1516163811 -14.8978083811
BXD64 m 0.275982 7.5990702277 15.3006943811 -14.7487303811
BXD66 m 0.35678 7.5990702277 15.3814923811 -14.6679323811
BXD67 m 0.2086575 8.4960187975 17.0067966132 -16.5894816132
BXD69 m 0.221144 7.5990702277 15.2458563811 -14.8035683811
BXD73 m 0.120144 7.5990702277 15.1448563811 -14.9045683811
BXD75 m 0.276312 7.5990702277 15.3010243811 -14.7484003811
BXD77 m 0.435182 7.5990702277 15.4598943811 -14.5895303811
BXD79 m 0.193094 7.5990702277 15.2178063811 -14.8316183811
BXD8 m 0.107496 7.5990702277 15.1322083811 -14.9172163811
BXD81 m 0.170832 7.5990702277 15.1955443811 -14.8538803811
BXD84 m 0.118756 7.5990702277 15.1434683811 -14.9059563811
BXD87 m 0.133676 7.5990702277 15.1583883811 -14.8910363811
BXD89 m 0.460054 7.5990702277 15.4847663811 -14.5646583811
BXD90 m 0.726658 7.5990702277 15.7513703811 -14.2980543811
C57BL/6J m 21.251099 5.3733540887 31.87517501 10.62702299
DBA/2J m 0.428304 7.5990702277 15.4530163811 -14.5964083811




  GWAS USING LINEAR MIXED MODELS