Project measure / variable:   Schoonjans1   aMCA_feces_CD

ID, description, units MPD:112760   aMCA_feces_CD   bile acid α-muricholic acid amount in feces, at 24 wks   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 24wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid α-muricholic acid amount in feces, at 24 wks CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means3.4587   ng/mL
Median of the strain means3.1304   ng/mL
SD of the strain means± 1.8168
Coefficient of variation (CV)0.5253
Min–max range of strain means0.63114   –   8.9271   ng/mL
Mean sample size per strain4.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 563.9292 16.1123 4.3648 < 0.0001
Residuals 139 513.1015 3.6914


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 1.7991 0.55781   5 0.24946 0.31 1.0997, 2.5383 -0.91
BXD100 m 4.2775 0.831   5 0.37163 0.1943 3.1411, 5.1436 0.45
BXD11 m 4.654 1.7125   4 0.85627 0.368 2.5001, 6.5981 0.66
BXD12 m 3.6099 1.8891   4 0.94455 0.5233 2.2479, 6.4004 0.08
BXD27 m 4.1113 1.8265   4 0.91323 0.4442 2.3547, 6.3159 0.36
BXD32 m 4.6673 4.4417   4 2.2209 0.9517 2.1611, 11.32 0.67
BXD34 m 1.3663 0.10905   4 0.05452 0.0798 1.2137, 1.4495 -1.15
BXD39 m 0.91392 0.45503   5 0.2035 0.4979 0.54593, 1.617 -1.4
BXD40 m 1.4933 0.44829   5 0.20048 0.3002 1.0163, 2.0814 -1.08
BXD43 m 1.9795 0.78441   4 0.39221 0.3963 1.0876, 2.9298 -0.81
BXD45 m 2.0919 0.84219   3 0.48624 0.4026 1.1202, 2.6107 -0.75
BXD48 m 5.6843 5.186   5 2.3193 0.9123 1.6191, 14.157 1.23
BXD48a m 4.4509 1.4239   4 0.71195 0.3199 3.4024, 6.5202 0.55
BXD49 m 2.0858 0.52858   5 0.23639 0.2534 1.3949, 2.7639 -0.76
BXD51 m 4.9814 1.7716   5 0.79229 0.3556 3.3361, 7.7664 0.84
BXD53 m 0.63114 0.2502   5 0.11189 0.3964 0.33918, 0.91795 -1.56
BXD55 m 5.1308 1.3229   5 0.59162 0.2578 3.4998, 7.1345 0.92
BXD6 m 2.1709 0.36778   5 0.16448 0.1694 1.7234, 2.6245 -0.71
BXD62 m 3.3576 1.1805   5 0.52795 0.3516 1.7619, 4.5178 -0.06
BXD63 m 2.6412 0.82888   5 0.37069 0.3138 1.72, 3.6315 -0.45
BXD64 m 2.0898 0.50629   5 0.22642 0.2423 1.6115, 2.9277 -0.75
BXD66 m 4.5754 0.87188   5 0.38992 0.1906 3.2635, 5.6107 0.61
BXD67 m 2.4313 0.27795   4 0.13898 0.1143 2.173, 2.8115 -0.57
BXD69 m 4.4196 2.2256   5 0.99534 0.5036 2.5369, 7.3336 0.53
BXD73 m 2.4436 0.93198   5 0.41679 0.3814 1.2357, 3.6299 -0.56
BXD75 m 5.3041 2.1117   5 0.94437 0.3981 3.0541, 8.6906 1.02
BXD77 m 5.4299 1.7946   5 0.80259 0.3305 3.0399, 7.5242 1.08
BXD79 m 2.0149 0.47831   5 0.2139 0.2374 1.4519, 2.6428 -0.79
BXD8 m 2.3418 0.94675   5 0.4234 0.4043 1.1617, 3.6643 -0.61
BXD81 m 3.174 0.98934   5 0.44245 0.3117 1.4993, 4.0113 -0.16
BXD84 m 3.0869 1.1293   5 0.50504 0.3658 1.7759, 4.3429 -0.2
BXD87 m 1.4127 0.39046   5 0.17462 0.2764 0.7802, 1.8493 -1.13
BXD89 m 4.8123 0.98508   5 0.44054 0.2047 3.8434, 6.1375 0.75
BXD90 m 8.9271 4.935   5 2.207 0.5528 3.9302, 16.988 3.01
C57BL/6J m 2.8285 0.93413   10 0.2954 0.3303 1.3633, 4.5815 -0.35
DBA/2J m 7.1232 4.7547   5 2.1264 0.6675 2.7235, 14.651 2.02


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 1.79914 0.8592296087 3.4979896424 0.1002903576
BXD100 m 4.2775 0.8592296087 5.9763496424 2.5786503576
BXD11 m 4.65405 0.9606479066 6.553421642 2.754678358
BXD12 m 3.609925 0.9606479066 5.509296642 1.710553358
BXD27 m 4.111325 0.9606479066 6.010696642 2.211953358
BXD32 m 4.667275 0.9606479066 6.566646642 2.767903358
BXD34 m 1.366325 0.9606479066 3.265696642 -0.533046642
BXD39 m 0.913922 0.8592296087 2.6127716424 -0.7849276424
BXD40 m 1.4933 0.8592296087 3.1921496424 -0.2055496424
BXD43 m 1.979475 0.9606479066 3.878846642 0.080103358
BXD45 m 2.0919333333 1.109260655 4.285138791 -0.1012721243
BXD48 m 5.68434 0.8592296087 7.3831896424 3.9854903576
BXD48a m 4.45095 0.9606479066 6.350321642 2.551578358
BXD49 m 2.08578 0.8592296087 3.7846296424 0.3869303576
BXD51 m 4.98142 0.8592296087 6.6802696424 3.2825703576
BXD53 m 0.631136 0.8592296087 2.3299856424 -1.0677136424
BXD55 m 5.13078 0.8592296087 6.8296296424 3.4319303576
BXD6 m 2.1709 0.8592296087 3.8697496424 0.4720503576
BXD62 m 3.35764 0.8592296087 5.0564896424 1.6587903576
BXD63 m 2.64122 0.8592296087 4.3400696424 0.9423703576
BXD64 m 2.08976 0.8592296087 3.7886096424 0.3909103576
BXD66 m 4.57536 0.8592296087 6.2742096424 2.8765103576
BXD67 m 2.4313 0.9606479066 4.330671642 0.531928358
BXD69 m 4.41964 0.8592296087 6.1184896424 2.7207903576
BXD73 m 2.44356 0.8592296087 4.1424096424 0.7447103576
BXD75 m 5.30408 0.8592296087 7.0029296424 3.6052303576
BXD77 m 5.4299 0.8592296087 7.1287496424 3.7310503576
BXD79 m 2.0149 0.8592296087 3.7137496424 0.3160503576
BXD8 m 2.34176 0.8592296087 4.0406096424 0.6429103576
BXD81 m 3.174 0.8592296087 4.8728496424 1.4751503576
BXD84 m 3.0869 0.8592296087 4.7857496424 1.3880503576
BXD87 m 1.41274 0.8592296087 3.1115896424 -0.2861096424
BXD89 m 4.81232 0.8592296087 6.5111696424 3.1134703576
BXD90 m 8.92708 0.8592296087 10.6259296424 7.2282303576
C57BL/6J m 2.82855 0.6075670829 4.0298181024 1.6272818976
DBA/2J m 7.12316 0.8592296087 8.8220096424 5.4243103576




  GWAS USING LINEAR MIXED MODELS