Project measure / variable:   Schoonjans1   keto_LCA_feces_HFD

ID, description, units MPD:112759   keto_LCA_feces_HFD   bile acid 7-ketolithocholic acid amount in feces, at 24 wks   [ng/mL]  HFD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 24wks
Procedure biomarker quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid 7-ketolithocholic acid amount in feces, at 24 wks HFD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means1.085   ng/mL
Median of the strain means0.99282   ng/mL
SD of the strain means± 0.57023
Coefficient of variation (CV)0.5256
Min–max range of strain means0.15877   –   2.3532   ng/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 53.3829 1.5252 6.7785 < 0.0001
Residuals 136 30.6012 0.225


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 1.1288 0.2886   5 0.12907 0.2557 0.76965, 1.4729 0.08
BXD100 m 0.40075 0.17379   4 0.0869 0.4337 0.25713, 0.65373 -1.2
BXD11 m 0.15877 0.11197   3 0.06465 0.7053 0.05074, 0.27431 -1.62
BXD12 m 0.71855 0.29761   4 0.14881 0.4142 0.27845, 0.92312 -0.64
BXD27 m 0.89167 1.0017   6 0.40894 1.1234 0.18599, 2.6257 -0.34
BXD32 m 1.2134 0.48102   4 0.24051 0.3964 0.9104, 1.9274 0.23
BXD34 m 1.0698 0.40141   4 0.20071 0.3752 0.55617, 1.5322 -0.03
BXD39 m 1.2138 0.28402   5 0.12702 0.234 0.82025, 1.6024 0.23
BXD40 m 0.76682 0.51598   5 0.23076 0.6729 0.30943, 1.5088 -0.56
BXD43 m 0.47453 0.35008   5 0.15656 0.7377 0.20075, 1.0537 -1.07
BXD45 m 1.712 0.3967   5 0.17741 0.2317 1.376, 2.3504 1.1
BXD48 m 1.6761 1.0418   5 0.46589 0.6215 0.72905, 3.4266 1.04
BXD48a m 2.2508 0.89211   5 0.39897 0.3963 1.475, 3.7673 2.04
BXD49 m 2.0802 0.21114   5 0.09443 0.1015 1.8228, 2.304 1.75
BXD51 m 0.8926 0.16389   5 0.07329 0.1836 0.7441, 1.1324 -0.34
BXD53 m 1.3314 0.68329   5 0.30558 0.5132 0.18191, 1.9906 0.43
BXD55 m 1.6661 0.5387   5 0.24091 0.3233 0.90799, 2.4129 1.02
BXD6 m 0.34077 0.11999   5 0.05366 0.3521 0.20692, 0.52533 -1.31
BXD62 m 1.0398 0.28991   5 0.12965 0.2788 0.68502, 1.3964 -0.08
BXD63 m 0.53304 0.12329   5 0.05514 0.2313 0.38909, 0.64376 -0.97
BXD64 m 0.82211 0.24932   5 0.1115 0.3033 0.60142, 1.1713 -0.46
BXD66 m 0.77379 0.22713   5 0.10158 0.2935 0.55593, 1.1352 -0.55
BXD67 m 1.0145 0.47588   5 0.21282 0.4691 0.664, 1.8332 -0.12
BXD69 m 1.1578 0.28247   5 0.12632 0.244 0.85985, 1.467 0.13
BXD73 m 2.3532 0.39283   5 0.17568 0.1669 1.8415, 2.7899 2.22
BXD75 m 1.7966 0.43413   5 0.19415 0.2416 1.4566, 2.5397 1.25
BXD77 m 1.1453 0.64875   5 0.29013 0.5664 0.60852, 2.2481 0.11
BXD79 m 0.52353 0.20173   5 0.09022 0.3853 0.27972, 0.83167 -0.98
BXD8 m 0.24147 0.138   4 0.069 0.5715 0.15141, 0.44673 -1.48
BXD81 m 0.77138 0.14141   5 0.06324 0.1833 0.65449, 0.99147 -0.55
BXD84 m 0.6364 0.18574   3 0.10724 0.2919 0.48274, 0.84281 -0.79
BXD87 m 0.83862 0.43811   5 0.19593 0.5224 0.3805, 1.4383 -0.43
BXD89 m 0.75375 0.16172   5 0.07232 0.2146 0.58099, 0.97369 -0.58
BXD90 m 1.9185 0.58994   5 0.26383 0.3075 1.2141, 2.5097 1.46
C57BL/6J m 1.7826 0.72287   5 0.32328 0.4055 0.85435, 2.5038 1.22
DBA/2J m 0.97115 0.32912   5 0.14719 0.3389 0.52716, 1.417 -0.2


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 1.128818 0.2121360364 1.5483299048 0.7093060952
BXD100 m 0.40075 0.2371752989 0.8697785682 -0.0682785682
BXD11 m 0.1587666667 0.2738664453 0.7003542069 -0.3828208736
BXD12 m 0.7185525 0.2371752989 1.1875810682 0.2495239318
BXD27 m 0.891675 0.1936528206 1.2746352223 0.5087147777
BXD32 m 1.2134125 0.2371752989 1.6824410682 0.7443839318
BXD34 m 1.0697925 0.2371752989 1.5388210682 0.6007639318
BXD39 m 1.21377 0.2121360364 1.6332819048 0.7942580952
BXD40 m 0.766822 0.2121360364 1.1863339048 0.3473100952
BXD43 m 0.474534 0.2121360364 0.8940459048 0.0550220952
BXD45 m 1.71204 0.2121360364 2.1315519048 1.2925280952
BXD48 m 1.67613 0.2121360364 2.0956419048 1.2566180952
BXD48a m 2.25084 0.2121360364 2.6703519048 1.8313280952
BXD49 m 2.08016 0.2121360364 2.4996719048 1.6606480952
BXD51 m 0.8926 0.2121360364 1.3121119048 0.4730880952
BXD53 m 1.331442 0.2121360364 1.7509539048 0.9119300952
BXD55 m 1.666098 0.2121360364 2.0856099048 1.2465860952
BXD6 m 0.34077 0.2121360364 0.7602819048 -0.0787419048
BXD62 m 1.039808 0.2121360364 1.4593199048 0.6202960952
BXD63 m 0.53304 0.2121360364 0.9525519048 0.1135280952
BXD64 m 0.822114 0.2121360364 1.2416259048 0.4026020952
BXD66 m 0.773794 0.2121360364 1.1933059048 0.3542820952
BXD67 m 1.014484 0.2121360364 1.4339959048 0.5949720952
BXD69 m 1.157768 0.2121360364 1.5772799048 0.7382560952
BXD73 m 2.35324 0.2121360364 2.7727519048 1.9337280952
BXD75 m 1.79658 0.2121360364 2.2160919048 1.3770680952
BXD77 m 1.145326 0.2121360364 1.5648379048 0.7258140952
BXD79 m 0.52353 0.2121360364 0.9430419048 0.1040180952
BXD8 m 0.241465 0.2371752989 0.7104935682 -0.2275635682
BXD81 m 0.771382 0.2121360364 1.1908939048 0.3518700952
BXD84 m 0.6363966667 0.2738664453 1.1779842069 0.0948091264
BXD87 m 0.83862 0.2121360364 1.2581319048 0.4191080952
BXD89 m 0.753754 0.2121360364 1.1732659048 0.3342420952
BXD90 m 1.91848 0.2121360364 2.3379919048 1.4989680952
C57BL/6J m 1.78261 0.2121360364 2.2021219048 1.3630980952
DBA/2J m 0.971146 0.2121360364 1.3906579048 0.5516340952




  GWAS USING LINEAR MIXED MODELS