Project measure / variable:   Schoonjans1   keto_LCA_feces_CD

ID, description, units MPD:112758   keto_LCA_feces_CD   bile acid 7-ketolithocholic acid amount in feces, at 24 wks   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 24wks
Procedure biomarker quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid 7-ketolithocholic acid amount in feces, at 24 wks CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means0.46872   ng/mL
Median of the strain means0.41583   ng/mL
SD of the strain means± 0.24083
Coefficient of variation (CV)0.5138
Min–max range of strain means0.16958   –   1.1938   ng/mL
Mean sample size per strain4.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 9.5271 0.2722 12.7259 < 0.0001
Residuals 139 2.9731 0.0214


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 0.6312 0.10863   5 0.04858 0.1721 0.49681, 0.76623 0.67
BXD100 m 0.63634 0.14183   5 0.06343 0.2229 0.49747, 0.84844 0.7
BXD11 m 0.16958 0.05361   4 0.0268 0.3161 0.12149, 0.24032 -1.24
BXD12 m 0.27712 0.29255   4 0.14627 1.0557 0.10504, 0.71492 -0.8
BXD27 m 0.32301 0.26939   4 0.13469 0.834 0.15439, 0.72542 -0.61
BXD32 m 0.24352 0.04771   4 0.02385 0.1959 0.19402, 0.30559 -0.94
BXD34 m 0.19924 0.05821   4 0.02911 0.2922 0.14544, 0.27843 -1.12
BXD39 m 0.43002 0.13382   5 0.05985 0.3112 0.27436, 0.57291 -0.16
BXD40 m 0.20852 0.09677   5 0.04328 0.4641 0.13614, 0.37834 -1.08
BXD43 m 0.19639 0.08288   4 0.04144 0.422 0.11558, 0.3039 -1.13
BXD45 m 0.52599 0.0596   3 0.03441 0.1133 0.47491, 0.59147 0.24
BXD48 m 0.28226 0.06572   5 0.02939 0.2329 0.17981, 0.35499 -0.77
BXD48a m 1.0134 0.17227   4 0.08613 0.17 0.8715, 1.2566 2.26
BXD49 m 0.92124 0.11072   5 0.04952 0.1202 0.81604, 1.0743 1.88
BXD51 m 0.57594 0.21031   5 0.09405 0.3652 0.35572, 0.8092 0.45
BXD53 m 0.35847 0.05682   5 0.02541 0.1585 0.27548, 0.4268 -0.46
BXD55 m 0.84664 0.25026   5 0.11192 0.2956 0.42689, 1.0353 1.57
BXD6 m 0.25971 0.02545   5 0.01138 0.098 0.21497, 0.27833 -0.87
BXD62 m 0.39618 0.07428   5 0.03322 0.1875 0.32092, 0.51463 -0.3
BXD63 m 0.38759 0.03983   5 0.01781 0.1028 0.35125, 0.45438 -0.34
BXD64 m 0.29816 0.1184   5 0.05295 0.3971 0.21446, 0.50444 -0.71
BXD66 m 0.39404 0.13234   5 0.05918 0.3359 0.27131, 0.55299 -0.31
BXD67 m 0.40366 0.16853   4 0.08427 0.4175 0.24725, 0.55217 -0.27
BXD69 m 0.74147 0.15318   5 0.06851 0.2066 0.4904, 0.90936 1.13
BXD73 m 1.1938 0.2522   5 0.11279 0.2112 0.82675, 1.4862 3.01
BXD75 m 0.63284 0.10683   5 0.04777 0.1688 0.48715, 0.7753 0.68
BXD77 m 0.44296 0.10323   5 0.04617 0.2331 0.37478, 0.6218 -0.11
BXD79 m 0.44908 0.07733   5 0.03458 0.1722 0.32163, 0.51103 -0.08
BXD8 m 0.22327 0.25168   5 0.11255 1.1273 0.07683, 0.66723 -1.02
BXD81 m 0.42799 0.10229   5 0.04575 0.239 0.27416, 0.51833 -0.17
BXD84 m 0.43485 0.16675   5 0.07457 0.3835 0.28977, 0.71878 -0.14
BXD87 m 0.31076 0.08491   5 0.03797 0.2732 0.23278, 0.42282 -0.66
BXD89 m 0.3427 0.04477   5 0.02002 0.1306 0.26992, 0.38265 -0.52
BXD90 m 0.55021 0.17656   5 0.07896 0.3209 0.35742, 0.79333 0.34
C57BL/6J m 0.55638 0.15212   10 0.0481 0.2734 0.29748, 0.82288 0.36
DBA/2J m 0.5894 0.18293   5 0.08181 0.3104 0.36981, 0.83632 0.5


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 0.631204 0.0654057538 0.7605227994 0.5018852006
BXD100 m 0.636342 0.0654057538 0.7656607994 0.5070232006
BXD11 m 0.16958 0.0731258558 0.3141628131 0.0249971869
BXD12 m 0.2771175 0.0731258558 0.4217003131 0.1325346869
BXD27 m 0.3230075 0.0731258558 0.4675903131 0.1784246869
BXD32 m 0.2435175 0.0731258558 0.3881003131 0.0989346869
BXD34 m 0.1992425 0.0731258558 0.3438253131 0.0546596869
BXD39 m 0.430016 0.0654057538 0.5593347994 0.3006972006
BXD40 m 0.208524 0.0654057538 0.3378427994 0.0792052006
BXD43 m 0.19639 0.0731258558 0.3409728131 0.0518071869
BXD45 m 0.52599 0.084438465 0.6929398521 0.3590401479
BXD48 m 0.282256 0.0654057538 0.4115747994 0.1529372006
BXD48a m 1.0134025 0.0731258558 1.1579853131 0.8688196869
BXD49 m 0.921236 0.0654057538 1.0505547994 0.7919172006
BXD51 m 0.575944 0.0654057538 0.7052627994 0.4466252006
BXD53 m 0.358472 0.0654057538 0.4877907994 0.2291532006
BXD55 m 0.84664 0.0654057538 0.9759587994 0.7173212006
BXD6 m 0.259708 0.0654057538 0.3890267994 0.1303892006
BXD62 m 0.396182 0.0654057538 0.5255007994 0.2668632006
BXD63 m 0.387594 0.0654057538 0.5169127994 0.2582752006
BXD64 m 0.298162 0.0654057538 0.4274807994 0.1688432006
BXD66 m 0.394038 0.0654057538 0.5233567994 0.2647192006
BXD67 m 0.4036625 0.0731258558 0.5482453131 0.2590796869
BXD69 m 0.741466 0.0654057538 0.8707847994 0.6121472006
BXD73 m 1.19385 0.0654057538 1.3231687994 1.0645312006
BXD75 m 0.632842 0.0654057538 0.7621607994 0.5035232006
BXD77 m 0.442958 0.0654057538 0.5722767994 0.3136392006
BXD79 m 0.44908 0.0654057538 0.5783987994 0.3197612006
BXD8 m 0.223266 0.0654057538 0.3525847994 0.0939472006
BXD81 m 0.427988 0.0654057538 0.5573067994 0.2986692006
BXD84 m 0.434852 0.0654057538 0.5641707994 0.3055332006
BXD87 m 0.310764 0.0654057538 0.4400827994 0.1814452006
BXD89 m 0.342698 0.0654057538 0.4720167994 0.2133792006
BXD90 m 0.550206 0.0654057538 0.6795247994 0.4208872006
C57BL/6J m 0.55638 0.046248852 0.6478222 0.4649378
DBA/2J m 0.589404 0.0654057538 0.7187227994 0.4600852006




  GWAS USING LINEAR MIXED MODELS