Project measure / variable:   Schoonjans1   keto_DCA_feces_HFD

ID, description, units MPD:112757   keto_DCA_feces_HFD   bile acid 7-ketodeoxycholic acid amount in feces, at 24 wks   [ng/mL]  HFD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 24wks
Procedure biomarker quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid 7-ketodeoxycholic acid amount in feces, at 24 wks HFD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means2.0616   ng/mL
Median of the strain means1.3706   ng/mL
SD of the strain means± 2.0857
Coefficient of variation (CV)1.0117
Min–max range of strain means0.14799   –   7.9402   ng/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 747.475 21.3564 4.7646 < 0.0001
Residuals 136 609.6004 4.4824


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 6.5706 2.4464   5 1.0941 0.3723 3.4932, 10.198 2.16
BXD100 m 0.52992 0.12409   4 0.06205 0.2342 0.42544, 0.70717 -0.73
BXD11 m 1.3411 1.0018   3 0.57839 0.747 0.19408, 2.0444 -0.35
BXD12 m 1.4334 0.83428   4 0.41714 0.582 0.21186, 2.0342 -0.3
BXD27 m 1.7308 2.0948   6 0.85521 1.2103 0.25067, 5.8585 -0.16
BXD32 m 1.6733 0.81945   4 0.40972 0.4897 1.0616, 2.8082 -0.19
BXD34 m 1.3171 0.69965   4 0.34982 0.5312 0.66046, 2.2991 -0.36
BXD39 m 0.73672 0.57277   5 0.25615 0.7775 0.3361, 1.7047 -0.64
BXD40 m 0.3411 0.27229   5 0.12177 0.7983 0.09315, 0.80234 -0.82
BXD43 m 1.3641 1.3274   5 0.59361 0.973 0.20165, 3.5245 -0.33
BXD45 m 1.377 0.98217   5 0.43924 0.7133 0.54972, 3.0368 -0.33
BXD48 m 7.9402 5.9853   5 2.6767 0.7538 1.5057, 16.968 2.82
BXD48a m 7.1479 6.76   5 3.0232 0.9457 2.7622, 19.068 2.44
BXD49 m 1.9336 0.75479   5 0.33755 0.3904 0.99749, 2.9674 -0.06
BXD51 m 5.8918 1.4931   5 0.66772 0.2534 4.1727, 7.3277 1.84
BXD53 m 1.403 1.0847   5 0.48511 0.7731 0.10997, 2.7694 -0.32
BXD55 m 1.4566 0.69149   5 0.30925 0.4747 0.42641, 2.174 -0.29
BXD6 m 2.4957 2.0581   5 0.92042 0.8247 0.45575, 5.6074 0.21
BXD62 m 0.52177 0.40687   5 0.18196 0.7798 0.11283, 1.1014 -0.74
BXD63 m 1.208 0.45831   5 0.20496 0.3794 0.51928, 1.8039 -0.41
BXD64 m 0.21764 0.11373   5 0.05086 0.5226 0.09471, 0.40484 -0.88
BXD66 m 0.68484 0.40645   5 0.18177 0.5935 0.25858, 1.1719 -0.66
BXD67 m 0.39465 0.26225   5 0.11728 0.6645 0.09517, 0.81041 -0.8
BXD69 m 0.94677 0.91886   5 0.41093 0.9705 0.22067, 2.4766 -0.53
BXD73 m 2.2269 1.7982   5 0.80419 0.8075 0.66171, 5.3207 0.08
BXD75 m 4.2336 2.6255   5 1.1741 0.6201 0.72041, 7.3389 1.04
BXD77 m 3.0785 2.6598   5 1.1895 0.864 0.22632, 6.876 0.49
BXD79 m 0.20227 0.13747   5 0.06148 0.6796 0.0833, 0.41359 -0.89
BXD8 m 0.14799 0.13804   4 0.06902 0.9327 0.03599, 0.34839 -0.92
BXD81 m 0.53551 0.67798   5 0.3032 1.266 0.0746, 1.6058 -0.73
BXD84 m 0.44424 0.34227   3 0.19761 0.7705 0.13951, 0.81456 -0.78
BXD87 m 2.912 1.7759   5 0.79421 0.6099 0.56278, 4.7977 0.41
BXD89 m 1.6765 1.0456   5 0.46762 0.6237 0.64121, 3.1993 -0.18
BXD90 m 1.3487 0.74296   5 0.33226 0.5509 0.78821, 2.6039 -0.34
C57BL/6J m 5.7198 4.6195   5 2.0659 0.8076 0.44781, 10.914 1.75
DBA/2J m 1.0352 0.57043   5 0.25511 0.551 0.47093, 1.9178 -0.49


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 6.57064 0.9468215797 8.4430372185 4.6982427815
BXD100 m 0.52992 1.0585787074 2.6233237307 -1.5634837307
BXD11 m 1.3411266667 1.2223414034 3.7583810816 -1.0761277483
BXD12 m 1.43344 1.0585787074 3.5268437307 -0.6599637307
BXD27 m 1.7308316667 0.8643258953 3.4400886553 0.021574678
BXD32 m 1.673325 1.0585787074 3.7667287307 -0.4200787307
BXD34 m 1.31709 1.0585787074 3.4104937307 -0.7763137307
BXD39 m 0.73672 0.9468215797 2.6091172185 -1.1356772185
BXD40 m 0.341098 0.9468215797 2.2134952185 -1.5312992185
BXD43 m 1.364138 0.9468215797 3.2365352185 -0.5082592185
BXD45 m 1.37697 0.9468215797 3.2493672185 -0.4954272185
BXD48 m 7.94022 0.9468215797 9.8126172185 6.0678227815
BXD48a m 7.14786 0.9468215797 9.0202572185 5.2754627815
BXD49 m 1.933578 0.9468215797 3.8059752185 0.0611807815
BXD51 m 5.89178 0.9468215797 7.7641772185 4.0193827815
BXD53 m 1.403038 0.9468215797 3.2754352185 -0.4693592185
BXD55 m 1.456622 0.9468215797 3.3290192185 -0.4157752185
BXD6 m 2.495742 0.9468215797 4.3681392185 0.6233447815
BXD62 m 0.521772 0.9468215797 2.3941692185 -1.3506252185
BXD63 m 1.207996 0.9468215797 3.0803932185 -0.6644012185
BXD64 m 0.217638 0.9468215797 2.0900352185 -1.6547592185
BXD66 m 0.68484 0.9468215797 2.5572372185 -1.1875572185
BXD67 m 0.394648 0.9468215797 2.2670452185 -1.4777492185
BXD69 m 0.946774 0.9468215797 2.8191712185 -0.9256232185
BXD73 m 2.226862 0.9468215797 4.0992592185 0.3544647815
BXD75 m 4.233642 0.9468215797 6.1060392185 2.3612447815
BXD77 m 3.078484 0.9468215797 4.9508812185 1.2060867815
BXD79 m 0.202274 0.9468215797 2.0746712185 -1.6701232185
BXD8 m 0.147995 1.0585787074 2.2413987307 -1.9454087307
BXD81 m 0.535512 0.9468215797 2.4079092185 -1.3368852185
BXD84 m 0.4442433333 1.2223414034 2.8614977483 -1.9730110816
BXD87 m 2.911996 0.9468215797 4.7843932185 1.0395987815
BXD89 m 1.676478 0.9468215797 3.5488752185 -0.1959192185
BXD90 m 1.348694 0.9468215797 3.2210912185 -0.5237032185
C57BL/6J m 5.719802 0.9468215797 7.5921992185 3.8474047815
DBA/2J m 1.035182 0.9468215797 2.9075792185 -0.8372152185




  GWAS USING LINEAR MIXED MODELS