Project measure / variable:   Schoonjans1   TUDCA_plasma_t60_HFD

ID, description, units MPD:112749   TUDCA_plasma_t60_HFD   plasma bile acid tauroursodeoxycholic acid amount, glucose kinetic test, at 20 wks of age, after 60 min   [ng/mL]  HFD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 20wks
Procedure biomarker quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Schoonjans1 - plasma bile acid tauroursodeoxycholic acid amount, glucose kinetic test, at 20 wks of age, after 60 min HFD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means44.754   ng/mL
Median of the strain means38.067   ng/mL
SD of the strain means± 30.616
Coefficient of variation (CV)0.6841
Min–max range of strain means4.5698   –   132.8   ng/mL
Mean sample size per strain4.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 144308.322 4123.0949 6.3098 < 0.0001
Residuals 121 79066.4961 653.4421


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 12.316 1.9782   5 0.88469 0.1606 9.642, 14.612 -1.06
BXD100 m 17.671 10.084   9 3.3612 0.5706 1.936, 32.354 -0.88
BXD11 m 36.277 23.251   3 13.424 0.6409 18.112, 62.48 -0.28
BXD12 m 85.06 75.14   4 37.572 0.8834 25.422, 192.9 1.32
BXD27 m 46.023 20.212   5 9.0391 0.4392 31.746, 79.19 0.04
BXD32 m 14.673 5.9435   4 2.9717 0.4051 9.724, 22.934 -0.98
BXD34 m 41.072 12.226   4 6.1129 0.2977 25.478, 53.44 -0.12
BXD39 m 30.601 21.95   3 12.673 0.7173 16.934, 55.92 -0.46
BXD40 m 114.7 17.965   4 8.9827 0.1566 92.89, 131.7 2.28
BXD43 m 21.983 7.8805   5 3.5243 0.3585 16.274, 35.189 -0.74
BXD45 m 132.8 56.71   5 25.363 0.4269 72.58, 199.1 2.88
BXD48 m 65.78 21.322   5 9.5357 0.3242 40.138, 90.02 0.69
BXD48a m 83.91 26.424   4 13.212 0.3149 54.35, 110.7 1.28
BXD49 m 104.1 35.015   5 15.659 0.3363 62.25, 139.2 1.94
BXD51 m 42.633 25.458   3 14.698 0.5971 27.311, 72.02 -0.07
BXD53 m 49.304 20.909   5 9.3508 0.4241 25.332, 81.49 0.15
BXD55 m 32.511 6.7771   5 3.0308 0.2085 23.804, 39.824 -0.4
BXD6 m 27.846 24.678   5 11.036 0.8862 4.882, 56.1 -0.55
BXD62 m 43.585 11.385   4 5.6924 0.2612 30.848, 54.03 -0.04
BXD63 m 10.9 3.5798   5 1.6009 0.3284 7.572, 16.094 -1.11
BXD64 m 18.492 19.756   5 8.8352 1.0684 7.022, 53.49 -0.86
BXD66 m 30.382 5.0639   3 2.9237 0.1667 26.056, 35.952 -0.47
BXD67 m 4.5698 1.5376   5 0.68764 0.3365 2.812, 6.358 -1.31
BXD69 m 49.108 31.202   4 15.601 0.6354 21.79, 91.71 0.14
BXD73 m 27.639 12.029   3 6.9447 0.4352 15.784, 39.834 -0.56
BXD75 m 49.974 35.959   4 17.979 0.7196 24.064, 101.7 0.17
BXD77 m 36.619 34.077   5 15.239 0.9306 15.998, 96.68 -0.27
BXD79 m 29.548 18.988   5 8.4915 0.6426 12.896, 51.47 -0.5
BXD8 m 33.051 11.192   3 6.4614 0.3386 20.188, 40.556 -0.38
BXD81 m 47.15 22.757   5 10.177 0.4827 24.304, 85.18 0.08
BXD84 m 39.515 31.534   5 14.103 0.798 12.066, 93.75 -0.17
BXD87 m 24.98 11.348   4 5.6741 0.4543 16.328, 41.658 -0.65
BXD89 m 44.285 7.9052   5 3.5353 0.1785 34.248, 55.92 -0.02
BXD90 m 54.1 10.151   4 5.0753 0.1876 43.136, 63.9 0.31
C57BL/6J m 98.54 76.45   2   54.06 0.7758 44.482, 152.6 1.76
DBA/2J m 9.4612 9.2778   3 5.3566 0.9806 3.744, 20.166 -1.15


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 12.3164 11.4319037475 34.9488687757 -10.3160687757
BXD100 m 17.6711111111 8.5208379639 34.5403573382 0.8018648841
BXD11 m 36.2766666667 14.7585242765 65.4950582173 7.058275116
BXD12 m 85.059 12.7812569458 110.3628693406 59.7551306594
BXD27 m 46.0228 11.4319037475 68.6552687757 23.3903312243
BXD32 m 14.673 12.7812569458 39.9768693406 -10.6308693406
BXD34 m 41.072 12.7812569458 66.3758693406 15.7681306594
BXD39 m 30.6013333333 14.7585242765 59.819724884 1.3829417827
BXD40 m 114.6975 12.7812569458 140.0013693406 89.3936306594
BXD43 m 21.9834 11.4319037475 44.6158687757 -0.6490687757
BXD45 m 132.836 11.4319037475 155.4684687757 110.2035312243
BXD48 m 65.7764 11.4319037475 88.4088687757 43.1439312243
BXD48a m 83.9125 12.7812569458 109.2163693406 58.6086306594
BXD49 m 104.106 11.4319037475 126.7384687757 81.4735312243
BXD51 m 42.633 14.7585242765 71.8513915507 13.4146084493
BXD53 m 49.304 11.4319037475 71.9364687757 26.6715312243
BXD55 m 32.5108 11.4319037475 55.1432687757 9.8783312243
BXD6 m 27.8464 11.4319037475 50.4788687757 5.2139312243
BXD62 m 43.585 12.7812569458 68.8888693406 18.2811306594
BXD63 m 10.9004 11.4319037475 33.5328687757 -11.7320687757
BXD64 m 18.492 11.4319037475 41.1244687757 -4.1404687757
BXD66 m 30.382 14.7585242765 59.6003915507 1.1636084493
BXD67 m 4.56982 11.4319037475 27.2022887757 -18.0626487757
BXD69 m 49.108 12.7812569458 74.4118693406 23.8041306594
BXD73 m 27.6393333333 14.7585242765 56.857724884 -1.5790582173
BXD75 m 49.9735 12.7812569458 75.2773693406 24.6696306594
BXD77 m 36.6188 11.4319037475 59.2512687757 13.9863312243
BXD79 m 29.5484 11.4319037475 52.1808687757 6.9159312243
BXD8 m 33.0513333333 14.7585242765 62.269724884 3.8329417827
BXD81 m 47.1496 11.4319037475 69.7820687757 24.5171312243
BXD84 m 39.5148 11.4319037475 62.1472687757 16.8823312243
BXD87 m 24.9795 12.7812569458 50.2833693406 -0.3243693406
BXD89 m 44.2848 11.4319037475 66.9172687757 21.6523312243
BXD90 m 54.105 12.7812569458 79.4088693406 28.8011306594
C57BL/6J m 98.541 18.0754269169 134.326075202 62.755924798
DBA/2J m 9.4611666667 14.7585242765 38.6795582173 -19.757224884




  GWAS USING LINEAR MIXED MODELS