Project measure / variable:   Schoonjans1   TaMCA_plasma_t60_HFD

ID, description, units MPD:112737   TaMCA_plasma_t60_HFD   plasma bile acid tauro-α-muricholic acid amount, glucose kinetic test, at 20 wks of age, after 60 min   [ng/mL]  HFD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 20wks
Procedure biomarker quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Schoonjans1 - plasma bile acid tauro-α-muricholic acid amount, glucose kinetic test, at 20 wks of age, after 60 min HFD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means114.9   ng/mL
Median of the strain means98.09   ng/mL
SD of the strain means± 74.11
Coefficient of variation (CV)0.645
Min–max range of strain means18.338   –   287.9   ng/mL
Mean sample size per strain4.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 763713.374 21820.3821 1.7971 0.0104
Residuals 121 1469170.731 12141.9069


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 27.002 11.004   5 4.9213 0.4075 18.366, 42.824 -1.19
BXD100 m 59.2 52.34   9 17.448 0.8842 4.702, 182.7 -0.75
BXD11 m 48.969 12.632   3 7.2933 0.258 38.352, 62.94 -0.89
BXD12 m 256.4 364.5   4 182.3 1.4214 28.018, 800.9 1.91
BXD27 m 179.1 104.3   5 46.662 0.5827 105.4, 352.9 0.87
BXD32 m 69.97 34.233   4 17.117 0.4893 39.13, 114.9 -0.61
BXD34 m 128.9 116.1   4 58.03 0.9003 36.89, 298.8 0.19
BXD39 m 89.35 82.67   3 47.729 0.9252 37.722, 184.7 -0.34
BXD40 m 147.1 46.811   4 23.405 0.3183 80.23, 182.7 0.43
BXD43 m 52.37 24.519   5 10.965 0.4682 26.752, 88.17 -0.84
BXD45 m 156.8 75.72   5 33.864 0.483 60.35, 235.1 0.57
BXD48 m 207.5 139.8   5 62.5 0.6735 47.71, 388.1 1.25
BXD48a m 281.3 215.4   4 107.7 0.7658 70.57, 505.5 2.25
BXD49 m 107.7 56.17   5 25.121 0.5214 64.26, 199.9 -0.1
BXD51 m 107.4 51.48   3 29.721 0.4795 77.34, 166.8 -0.1
BXD53 m 140.8 169.8   5 75.94 1.2058 23.164, 404.8 0.35
BXD55 m 56.66 9.8632   5 4.411 0.1741 47.738, 73.11 -0.79
BXD6 m 75.05 79.26   5 35.446 1.0561 14.014, 210.7 -0.54
BXD62 m 75.38 10.732   4 5.3662 0.1424 59.29, 81.16 -0.53
BXD63 m 37.974 17.5   5 7.8261 0.4608 19.156, 57.63 -1.04
BXD64 m 105.0 101.8   5 45.539 0.9695 37.542, 283.5 -0.13
BXD66 m 67.38 52.96   3 30.574 0.7859 33.432, 128.4 -0.64
BXD67 m 18.338 6.0544   5 2.7076 0.3302 12.838, 28.714 -1.3
BXD69 m 247.9 186.6   4 93.3 0.7527 31.038, 455.6 1.79
BXD73 m 149.7 75.11   3 43.367 0.5019 84.27, 231.7 0.47
BXD75 m 165.9 176.4   4 88.22 1.0632 48.862, 424.6 0.69
BXD77 m 168.1 141.7   5 63.39 0.8434 52.42, 364.4 0.72
BXD79 m 122.8 123.2   5 55.09 1.003 17.136, 310.1 0.11
BXD8 m 51.65 47.331   3 27.327 0.9164 24.208, 106.3 -0.85
BXD81 m 174.4 127.2   5 56.91 0.7297 20.774, 327.2 0.8
BXD84 m 55.09 61.77   5 27.623 1.1211 13.272, 163.6 -0.81
BXD87 m 41.322 15.26   4 7.6302 0.3693 28.188, 57.73 -0.99
BXD89 m 54.22 17.113   5 7.6532 0.3156 33.716, 79.77 -0.82
BXD90 m 91.17 45.823   4 22.911 0.5026 38.925, 150.1 -0.32
C57BL/6J m 287.9 210.0   2   148.5 0.7295 139.4, 436.4 2.33
DBA/2J m 30.78 38.357   3 22.146 1.2462 6.222, 74.98 -1.14


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 27.0016 49.2786096954 124.5616057417 -70.5584057417
BXD100 m 59.1951111111 36.7301070386 131.912046019 -13.5218237968
BXD11 m 48.9693333333 63.6184115582 174.9187591645 -76.9800924978
BXD12 m 256.4395 55.0951605578 365.5149023618 147.3640976382
BXD27 m 179.06 49.2786096954 276.6200057417 81.4999942583
BXD32 m 69.967 55.0951605578 179.0424023618 -39.1084023618
BXD34 m 128.92 55.0951605578 237.9954023618 19.8445976382
BXD39 m 89.3513333333 63.6184115582 215.3007591645 -36.5980924978
BXD40 m 147.0575 55.0951605578 256.1329023618 37.9820976382
BXD43 m 52.368 49.2786096954 149.9280057417 -45.1920057417
BXD45 m 156.788 49.2786096954 254.3480057417 59.2279942583
BXD48 m 207.502 49.2786096954 305.0620057417 109.9419942583
BXD48a m 281.2675 55.0951605578 390.3429023618 172.1920976382
BXD49 m 107.744 49.2786096954 205.3040057417 10.1839942583
BXD51 m 107.36 63.6184115582 233.3094258311 -18.5894258311
BXD53 m 140.8288 49.2786096954 238.3888057417 43.2687942583
BXD55 m 56.6616 49.2786096954 154.2216057417 -40.8984057417
BXD6 m 75.0452 49.2786096954 172.6052057417 -22.5148057417
BXD62 m 75.375 55.0951605578 184.4504023618 -33.7004023618
BXD63 m 37.974 49.2786096954 135.5340057417 -59.5860057417
BXD64 m 105.0292 49.2786096954 202.5892057417 7.4691942583
BXD66 m 67.382 63.6184115582 193.3314258311 -58.5674258311
BXD67 m 18.3382 49.2786096954 115.8982057417 -79.2218057417
BXD69 m 247.9095 55.0951605578 356.9849023618 138.8340976382
BXD73 m 149.6566666667 63.6184115582 275.6060924978 23.7072408355
BXD75 m 165.948 55.0951605578 275.0234023618 56.8725976382
BXD77 m 168.074 49.2786096954 265.6340057417 70.5139942583
BXD79 m 122.828 49.2786096954 220.3880057417 25.2679942583
BXD8 m 51.6466666667 63.6184115582 177.5960924978 -74.3027591645
BXD81 m 174.3948 49.2786096954 271.9548057417 76.8347942583
BXD84 m 55.0944 49.2786096954 152.6544057417 -42.4656057417
BXD87 m 41.322 55.0951605578 150.3974023618 -67.7534023618
BXD89 m 54.2156 49.2786096954 151.7756057417 -43.3444057417
BXD90 m 91.16625 55.0951605578 200.2416523618 -17.9091523618
C57BL/6J m 287.9 77.916323282 442.1559133414 133.6440866586
DBA/2J m 30.78 63.6184115582 156.7294258311 -95.1694258311




  GWAS USING LINEAR MIXED MODELS