Project measure / variable:   Schoonjans1   CDCA_plasma_t60_CD

ID, description, units MPD:112728   CDCA_plasma_t60_CD   plasma bile acid chenodeoxycholic acid amount, glucose kinetic test, at 20 wks of age, after 60 min   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 20wks
Procedure biomarker quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Schoonjans1 - plasma bile acid chenodeoxycholic acid amount, glucose kinetic test, at 20 wks of age, after 60 min CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means2.5117   ng/mL
Median of the strain means1.5972   ng/mL
SD of the strain means± 3.098
Coefficient of variation (CV)1.2334
Min–max range of strain means0.1885   –   16.456   ng/mL
Mean sample size per strain4.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 1618.6068 46.2459 3.5242 < 0.0001
Residuals 125 1640.2929 13.1223


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 0.992 1.0256   5 0.45867 1.0339 0.318, 2.798 -0.49
BXD100 m 1.0224 0.52716   5 0.23575 0.5156 0.53, 1.824 -0.48
BXD11 m 0.3745 0.3783   4 0.18915 1.0101 0.006, 0.904 -0.69
BXD12 m 5.078 4.7997   3 2.7711 0.9452 1.2, 10.446 0.83
BXD27 m 1.4126 0.47661   4 0.23831 0.3374 0.93636, 1.962 -0.35
BXD32 m 3.3448 3.8914   5 1.7403 1.1634 0.738, 10.142 0.27
BXD34 m 1.898 0.61002   5 0.27281 0.3214 1.118, 2.824 -0.2
BXD39 m 0.58667 0.20673   3 0.11936 0.3524 0.348, 0.71 -0.62
BXD40 m 4.808 4.4138   4 2.2069 0.918 0.82, 11.07 0.74
BXD43 m 1.2372 1.0621   5 0.47499 0.8585 0.02, 2.92 -0.41
BXD45 m 2.475 3.4796   4 1.7398 1.4059 0.654, 7.692 -0.01
BXD48 m 1.5412 1.0056   5 0.44974 0.6525 0.47, 2.642 -0.31
BXD48a m 2.3245 0.35202   4 0.17601 0.1514 1.964, 2.758 -0.06
BXD49 m 4.1076 3.514   5 1.5715 0.8555 1.34, 9.87 0.52
BXD51 m 0.7035 0.47443   4 0.23722 0.6744 0.074, 1.22 -0.58
BXD53 m 0.38 0.21545   4 0.10772 0.567 0.144, 0.65 -0.69
BXD55 m 5.4932 2.1079   5 0.94269 0.3837 1.972, 7.162 0.96
BXD6 m 16.456 13.236   5 5.9194 0.8044 6.94, 38.574 4.5
BXD62 m 1.9952 1.2068   5 0.53971 0.6049 0.492, 3.242 -0.17
BXD63 m 0.477 0.3513   4 0.17565 0.7365 0.07, 0.904 -0.66
BXD64 m 0.3388 0.23805   5 0.10646 0.7026 0.07, 0.602 -0.7
BXD66 m 0.9836 0.23562   5 0.10537 0.2395 0.794, 1.322 -0.49
BXD67 m 0.4325 0.39271   4 0.19635 0.908 0.076, 0.992 -0.67
BXD69 m 2.2812 2.6911   5 1.2035 1.1797 0.444, 6.954 -0.07
BXD73 m 2.859 3.1484   4 1.5742 1.1012 0.976, 7.57 0.11
BXD75 m 1.402 0.66511   5 0.29744 0.4744 0.592, 2.424 -0.36
BXD77 m 9.9728 9.8702   5 4.4141 0.9897 1.724, 25.04 2.41
BXD79 m 1.4045 0.91178   4 0.45589 0.6492 0.606, 2.502 -0.36
BXD8 m 0.5364 0.50768   5 0.22704 0.9465 0.17, 1.422 -0.64
BXD81 m 1.6533 1.1099   3 0.64079 0.6713 0.68, 2.862 -0.28
BXD84 m 0.1885 0.11289   4 0.05645 0.5989 0.03, 0.294 -0.75
BXD87 m 2.3608 1.8158   5 0.81206 0.7692 0.622, 5.252 -0.05
BXD89 m 2.0732 2.9069   5 1.3 1.4022 0.418, 7.212 -0.14
BXD90 m 1.9124 1.678   5 0.75043 0.8774 0.64, 4.404 -0.19
C57BL/6J m 4.6496 5.72   5 2.558 1.2302 0.996, 14.726 0.69
DBA/2J m 0.665 0.50347   4 0.25174 0.7571 0.07, 1.214 -0.6


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 0.992 1.6200211918 4.1982229985 -2.2142229985
BXD100 m 1.0224 1.6200211918 4.2286229985 -2.1838229985
BXD11 m 0.3745 1.811238755 3.9591662879 -3.2101662879
BXD12 m 5.078 2.0914383655 9.2172160925 0.9387839075
BXD27 m 1.41259 1.811238755 4.9972562879 -2.1720762879
BXD32 m 3.3448 1.6200211918 6.5510229985 0.1385770015
BXD34 m 1.898 1.6200211918 5.1042229985 -1.3082229985
BXD39 m 0.5866666667 2.0914383655 4.7258827592 -3.5525494259
BXD40 m 4.808 1.811238755 8.3926662879 1.2233337121
BXD43 m 1.2372 1.6200211918 4.4434229985 -1.9690229985
BXD45 m 2.475 1.811238755 6.0596662879 -1.1096662879
BXD48 m 1.5412 1.6200211918 4.7474229985 -1.6650229985
BXD48a m 2.3245 1.811238755 5.9091662879 -1.2601662879
BXD49 m 4.1076 1.6200211918 7.3138229985 0.9013770015
BXD51 m 0.7035 1.811238755 4.2881662879 -2.8811662879
BXD53 m 0.38 1.811238755 3.9646662879 -3.2046662879
BXD55 m 5.4932 1.6200211918 8.6994229985 2.2869770015
BXD6 m 16.4556 1.6200211918 19.6618229985 13.2493770015
BXD62 m 1.9952 1.6200211918 5.2014229985 -1.2110229985
BXD63 m 0.477 1.811238755 4.0616662879 -3.1076662879
BXD64 m 0.3388 1.6200211918 3.5450229985 -2.8674229985
BXD66 m 0.9836 1.6200211918 4.1898229985 -2.2226229985
BXD67 m 0.4325 1.811238755 4.0171662879 -3.1521662879
BXD69 m 2.2812 1.6200211918 5.4874229985 -0.9250229985
BXD73 m 2.859 1.811238755 6.4436662879 -0.7256662879
BXD75 m 1.402 1.6200211918 4.6082229985 -1.8042229985
BXD77 m 9.9728 1.6200211918 13.1790229985 6.7665770015
BXD79 m 1.4045 1.811238755 4.9891662879 -2.1801662879
BXD8 m 0.5364 1.6200211918 3.7426229985 -2.6698229985
BXD81 m 1.6533333333 2.0914383655 5.7925494259 -2.4858827592
BXD84 m 0.1885 1.811238755 3.7731662879 -3.3961662879
BXD87 m 2.3608 1.6200211918 5.5670229985 -0.8454229985
BXD89 m 2.0732 1.6200211918 5.2794229985 -1.1330229985
BXD90 m 1.9124 1.6200211918 5.1186229985 -1.2938229985
C57BL/6J m 4.6496 1.6200211918 7.8558229985 1.4433770015
DBA/2J m 0.665 1.811238755 4.2496662879 -2.9196662879




  GWAS USING LINEAR MIXED MODELS