Project measure / variable:   Schoonjans1   bMCA_plasma_t60_CD

ID, description, units MPD:112724   bMCA_plasma_t60_CD   plasma bile acid β-muricholic acid, glucose kinetic test, at 20 wks of age, after 60 min   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 20wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - plasma bile acid β-muricholic acid, glucose kinetic test, at 20 wks of age, after 60 min CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means28.249   ng/mL
Median of the strain means16.873   ng/mL
SD of the strain means± 27.69
Coefficient of variation (CV)0.9802
Min–max range of strain means1.825   –   110.4   ng/mL
Mean sample size per strain4.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 126582.8863 3616.6539 1.9081 0.0049
Residuals 129 244507.4341 1895.4065


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 14.806 18.135   5 8.11 1.2248 3.088, 45.59 -0.49
BXD100 m 4.4 1.3826   5 0.61832 0.3142 2.75, 6.518 -0.86
BXD11 m 13.524 6.7052   4 3.3526 0.4958 6.936, 20.756 -0.53
BXD12 m 15.783 15.216   3 8.7849 0.9641 3.886, 32.928 -0.45
BXD27 m 93.21 63.45   4 31.727 0.6808 41.568, 180.1 2.35
BXD32 m 79.67 135.5   5 60.58 1.7004 7.906, 321.2 1.86
BXD34 m 16.918 8.9355   5 3.9961 0.5282 5.986, 24.242 -0.41
BXD39 m 23.855 18.606   3 10.742 0.78 2.422, 35.86 -0.16
BXD40 m 57.16 71.95   4 35.975 1.2588 8.054, 162.5 1.04
BXD43 m 11.205 15.355   6 6.2687 1.3703 1.76, 42.184 -0.62
BXD45 m 30.265 47.238   4 23.619 1.5608 3.606, 101.0 0.07
BXD48 m 10.932 5.4246   5 2.4259 0.4962 2.434, 16.866 -0.63
BXD48a m 14.661 6.621   4 3.3105 0.4516 5.948, 21.824 -0.49
BXD49 m 12.018 8.2546   5 3.6916 0.6869 4.52, 25.616 -0.59
BXD51 m 18.628 24.46   5 10.939 1.3131 2.178, 61.7 -0.35
BXD53 m 5.7545 2.7537   4 1.3768 0.4785 1.71, 7.828 -0.81
BXD55 m 29.532 22.187   5 9.9222 0.7513 4.51, 62.83 0.05
BXD6 m 110.4 104.5   5 46.736 0.947 37.548, 283.4 2.97
BXD62 m 73.64 46.727   5 20.897 0.6345 28.166, 150.5 1.64
BXD63 m 1.825 0.62658   4 0.31329 0.3433 1.196, 2.48 -0.95
BXD64 m 9.8612 1.8526   5 0.82852 0.1879 7.05, 12.104 -0.66
BXD66 m 11.327 5.8427   5 2.6129 0.5158 6.53, 20.108 -0.61
BXD67 m 14.834 10.607   4 5.3033 0.715 4.642, 27.382 -0.48
BXD69 m 13.207 19.21   5 8.591 1.4545 3.194, 47.43 -0.54
BXD73 m 22.311 10.345   4 5.1725 0.4637 13.684, 36.51 -0.21
BXD75 m 16.828 12.512   5 5.5955 0.7435 5.696, 36.308 -0.41
BXD77 m 85.65 110.7   5 49.494 1.2922 11.834, 262.9 2.07
BXD79 m 28.331 25.429   5 11.372 0.8976 5.53, 65.59 0.0
BXD8 m 16.972 14.375   5 6.4285 0.847 8.002, 42.464 -0.41
BXD81 m 12.309 9.2341   3 5.3313 0.7502 5.458, 22.81 -0.58
BXD84 m 8.2516 3.3808   5 1.5119 0.4097 4.22, 13.206 -0.72
BXD87 m 34.165 23.667   5 10.584 0.6927 18.688, 75.04 0.21
BXD89 m 18.171 21.173   5 9.4689 1.1652 2.202, 44.81 -0.36
BXD90 m 9.8524 13.375   5 5.9816 1.3576 1.232, 31.926 -0.66
C57BL/6J m 57.91 59.24   5 26.493 1.0229 13.798, 162.1 1.07
DBA/2J m 18.794 18.621   4 9.3103 0.9907 4.024, 44.27 -0.34


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 14.806 19.4700100954 53.3278918231 -23.7158918231
BXD100 m 4.4 19.4700100954 42.9218918231 -34.1218918231
BXD11 m 13.524 21.768133048 56.5927843692 -29.5447843692
BXD12 m 15.7826666667 25.13567495 65.5142151651 -33.9488818318
BXD27 m 93.2095 21.768133048 136.2782843692 50.1407156308
BXD32 m 79.6696 19.4700100954 118.1914918231 41.1477081769
BXD34 m 16.9184 19.4700100954 55.4402918231 -21.6034918231
BXD39 m 23.8553333333 25.13567495 73.5868818318 -25.8762151651
BXD40 m 57.157 21.768133048 100.2257843692 14.0882156308
BXD43 m 11.2053333333 17.7736062069 46.3708485155 -23.9601818488
BXD45 m 30.2655 21.768133048 73.3342843692 -12.8032843692
BXD48 m 10.9324 19.4700100954 49.4542918231 -27.5894918231
BXD48a m 14.661 21.768133048 57.7297843692 -28.4077843692
BXD49 m 12.0176 19.4700100954 50.5394918231 -26.5042918231
BXD51 m 18.6276 19.4700100954 57.1494918231 -19.8942918231
BXD53 m 5.7545 21.768133048 48.8232843692 -37.3142843692
BXD55 m 29.532 19.4700100954 68.0538918231 -8.9898918231
BXD6 m 110.3528 19.4700100954 148.8746918231 71.8309081769
BXD62 m 73.6412 19.4700100954 112.1630918231 35.1193081769
BXD63 m 1.825 21.768133048 44.8937843692 -41.2437843692
BXD64 m 9.8612 19.4700100954 48.3830918231 -28.6606918231
BXD66 m 11.3268 19.4700100954 49.8486918231 -27.1950918231
BXD67 m 14.834 21.768133048 57.9027843692 -28.2347843692
BXD69 m 13.2072 19.4700100954 51.7290918231 -25.3146918231
BXD73 m 22.3105 21.768133048 65.3792843692 -20.7582843692
BXD75 m 16.8276 19.4700100954 55.3494918231 -21.6942918231
BXD77 m 85.6484 19.4700100954 124.1702918231 47.1265081769
BXD79 m 28.3312 19.4700100954 66.8530918231 -10.1906918231
BXD8 m 16.972 19.4700100954 55.4938918231 -21.5498918231
BXD81 m 12.3086666667 25.13567495 62.0402151651 -37.4228818318
BXD84 m 8.2516 19.4700100954 46.7734918231 -30.2702918231
BXD87 m 34.1648 19.4700100954 72.6866918231 -4.3570918231
BXD89 m 18.1712 19.4700100954 56.6930918231 -20.3506918231
BXD90 m 9.8524 19.4700100954 48.3742918231 -28.6694918231
C57BL/6J m 57.914 19.4700100954 96.4358918231 19.3921081769
DBA/2J m 18.7945 21.768133048 61.8632843692 -24.2742843692




  GWAS USING LINEAR MIXED MODELS