Project measure / variable:   Schoonjans1   UDCA_plasma_t30_CD

ID, description, units MPD:112714   UDCA_plasma_t30_CD   plasma bile acid ursodeoxycholic acid amount, glucose kinetic test, at 20 wks of age, after 30 min   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   28 strains     sex: m     age: 20wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - plasma bile acid ursodeoxycholic acid amount, glucose kinetic test, at 20 wks of age, after 30 min CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested28 strains
Mean of the strain means7.1907   ng/mL
Median of the strain means5.3708   ng/mL
SD of the strain means± 6.1416
Coefficient of variation (CV)0.8541
Min–max range of strain means1.43   –   31.883   ng/mL
Mean sample size per strain2.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 16 3500.3602 218.7725 1.0547 0.4314
Residuals 33 6845.1687 207.4294


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 9.3781 0.0   1   0.0 0.0 9.3781, 9.3781 0.36
BXD100 m 1.801 0.02687   2   0.019 0.0149 1.782, 1.82 -0.88
BXD12 m 8.67 0.0   1   0.0 0.0 8.67, 8.67 0.24
BXD27 m 10.828 5.1053   2   3.61 0.4715 7.218, 14.438 0.59
BXD32 m 17.488 24.43   3 14.104 1.3969 1.598, 45.618 1.68
BXD34 m 5.324 2.3646   2   1.672 0.4441 3.652, 6.996 -0.3
BXD39 m 4.328 4.4152   2   3.122 1.0201 1.206, 7.45 -0.47
BXD40 m 7.6687 4.185   3 2.4162 0.5457 4.444, 12.398 0.08
BXD43 m 5.076 0.0   1   0.0 0.0 5.076, 5.076 -0.34
BXD45 m 5.3765 6.1463   4 3.0732 1.1432 1.786, 14.564 -0.3
BXD48 m 7.106 0.0   1   0.0 0.0 7.106, 7.106 -0.01
BXD49 m 9.886 4.305   3 2.4855 0.4355 5.334, 13.892 0.44
BXD53 m 2.776 0.0   1   0.0 0.0 2.776, 2.776 -0.72
BXD55 m 8.4296 7.6823   5 3.4356 0.9113 2.342, 18.38 0.2
BXD6 m 31.883 33.934   5 15.176 1.0643 4.302, 81.61 4.02
BXD62 m 1.952 0.25465   3 0.14702 0.1305 1.744, 2.236 -0.85
BXD69 m 2.458 0.0   1   0.0 0.0 2.458, 2.458 -0.77
BXD73 m 12.305 14.63   2   10.345 1.189 1.96, 22.65 0.83
BXD75 m 1.43 0.0   1   0.0 0.0 1.43, 1.43 -0.94
BXD77 m 10.997 11.813   3 6.8202 1.0742 3.036, 24.57 0.62
BXD79 m 7.664 0.0   1   0.0 0.0 7.664, 7.664 0.08
BXD8 m 1.513 0.07495   2   0.053 0.0495 1.46, 1.566 -0.92
BXD81 m 3.3929 2.12   2   1.4991 0.6248 1.8938, 4.892 -0.62
BXD87 m 5.633 1.2799   2   0.905 0.2272 4.728, 6.538 -0.25
BXD89 m 5.306 0.0   1   0.0 0.0 5.306, 5.306 -0.31
BXD90 m 3.138 0.0   1   0.0 0.0 3.138, 3.138 -0.66
C57BL/6J m 5.3652 4.2887   5 1.918 0.7994 1.734, 12.086 -0.3
DBA/2J m 4.166 0.0   1   0.0 0.0 4.166, 4.166 -0.49


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD100 m 1.801 10.1840403118 22.5205858042 -18.9185858042
BXD27 m 10.828 10.1840403118 31.5475858042 -9.8915858042
BXD32 m 17.488 8.3152340946 34.4054709673 0.5705290327
BXD34 m 5.324 10.1840403118 26.0435858042 -15.3955858042
BXD39 m 4.328 10.1840403118 25.0475858042 -16.3915858042
BXD40 m 7.6686666667 8.3152340946 24.586137634 -9.2488043007
BXD45 m 5.3765 7.2012039643 20.0274596255 -9.2744596255
BXD49 m 9.886 8.3152340946 26.8034709673 -7.0314709673
BXD55 m 8.4296 6.4409526336 21.5338166633 -4.6746166633
BXD6 m 31.8828 6.4409526336 44.9870166633 18.7785833367
BXD62 m 1.952 8.3152340946 18.8694709673 -14.9654709673
BXD73 m 12.305 10.1840403118 33.0245858042 -8.4145858042
BXD77 m 10.9973333333 8.3152340946 27.9148043007 -5.920137634
BXD8 m 1.513 10.1840403118 22.2325858042 -19.2065858042
BXD81 m 3.3929 10.1840403118 24.1124858042 -17.3266858042
BXD87 m 5.633 10.1840403118 26.3525858042 -15.0865858042
C57BL/6J m 5.3652 6.4409526336 18.4694166633 -7.7390166633




  GWAS USING LINEAR MIXED MODELS