Project measure / variable:   Schoonjans1   THDCA_plasma_t30_HFD

ID, description, units MPD:112711   THDCA_plasma_t30_HFD   plasma bile acid taurohyodeoxycholic acid amount, glucose kinetic test, at 20 wks of age, after 30 min   [ng/mL]  HFD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 20wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - plasma bile acid taurohyodeoxycholic acid amount, glucose kinetic test, at 20 wks of age, after 30 min HFD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means10.709   ng/mL
Median of the strain means7.5167   ng/mL
SD of the strain means± 9.2987
Coefficient of variation (CV)0.8683
Min–max range of strain means1.001   –   35.813   ng/mL
Mean sample size per strain4.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 12974.1143 370.689 4.2057 < 0.0001
Residuals 120 10576.8366 88.1403


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 4.5433 1.7183   5 0.76846 0.3782 3.232, 7.4719 -0.66
BXD100 m 3.511 1.8414   8 0.65104 0.5245 0.544, 5.844 -0.77
BXD11 m 3.6513 2.0168   3 1.1644 0.5524 2.068, 5.922 -0.76
BXD12 m 29.649 24.004   4 12.002 0.8096 4.048, 56.53 2.04
BXD27 m 3.5604 1.5901   5 0.71109 0.4466 1.158, 5.424 -0.77
BXD32 m 1.9995 1.7626   4 0.88128 0.8815 0.39, 4.404 -0.94
BXD34 m 8.0515 6.6584   4 3.3292 0.827 2.3, 14.59 -0.29
BXD39 m 7.9473 8.8418   3 5.1048 1.1125 2.342, 18.14 -0.3
BXD40 m 19.776 4.7503   4 2.3752 0.2402 14.112, 25.716 0.98
BXD43 m 1.6675 0.62695   5 0.28038 0.376 0.87941, 2.572 -0.97
BXD45 m 8.3208 5.6172   5 2.5121 0.6751 3.62, 17.87 -0.26
BXD48 m 11.672 4.3899   5 1.9632 0.3761 8.1, 17.762 0.1
BXD48a m 16.591 12.515   4 6.2577 0.7543 6.398, 34.58 0.63
BXD49 m 5.0644 3.4646   5 1.5494 0.6841 1.396, 9.634 -0.61
BXD51 m 7.3493 2.2957   3 1.3254 0.3124 5.492, 9.9159 -0.36
BXD53 m 6.0764 1.5579   5 0.69671 0.2564 4.018, 7.676 -0.5
BXD55 m 2.6656 0.74473   5 0.33305 0.2794 1.778, 3.598 -0.87
BXD6 m 6.5573 6.2116   5 2.7779 0.9473 0.954, 16.945 -0.45
BXD62 m 1.001 0.32377   4 0.16189 0.3234 0.678, 1.442 -1.04
BXD63 m 9.8956 3.3854   5 1.514 0.3421 6.498, 14.018 -0.09
BXD64 m 14.73 7.3425   5 3.2836 0.4985 5.936, 25.296 0.43
BXD66 m 5.5173 1.6554   3 0.95576 0.3 3.744, 7.022 -0.56
BXD67 m 4.064 2.4554   5 1.0981 0.6042 1.678, 7.992 -0.71
BXD69 m 30.076 19.997   4 9.9985 0.6649 6.124, 53.92 2.08
BXD73 m 7.684 3.8836   3 2.2422 0.5054 3.238, 10.414 -0.33
BXD75 m 15.925 6.658   4 3.329 0.4181 10.218, 24.324 0.56
BXD77 m 8.4864 1.3387   5 0.59867 0.1577 6.99, 9.92 -0.24
BXD79 m 10.62 15.988   5 7.15 1.5054 1.602, 39.06 -0.01
BXD8 m 5.576 3.0886   2   2.184 0.5539 3.392, 7.76 -0.55
BXD81 m 24.384 8.5202   5 3.8104 0.3494 15.68, 36.854 1.47
BXD84 m 35.813 25.604   5 11.451 0.7149 15.632, 75.9 2.7
BXD87 m 3.4365 2.7453   4 1.3726 0.7989 0.6, 7.052 -0.78
BXD89 m 18.475 18.203   5 8.1407 0.9853 8.538, 50.97 0.84
BXD90 m 4.063 1.1093   4 0.55465 0.273 2.552, 5.18 -0.71
C57BL/6J m 31.047 15.871   3 9.1633 0.5112 20.52, 49.302 2.19
DBA/2J m 6.0795 5.7854   3 3.3402 0.9516 1.684, 12.634 -0.5


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 4.54332 4.1985784502 12.8562131318 -3.7695731318
BXD100 m 3.511 3.3192677094 10.0829190605 -3.0609190605
BXD11 m 3.6513333333 5.4203414718 14.3832322194 -7.0805655527
BXD12 m 29.6495 4.6941534118 38.9435970662 20.3554029338
BXD27 m 3.5604 4.1985784502 11.8732931318 -4.7524931318
BXD32 m 1.9995 4.6941534118 11.2935970662 -7.2945970662
BXD34 m 8.0515 4.6941534118 17.3455970662 -1.2425970662
BXD39 m 7.9473333333 5.4203414718 18.6792322194 -2.7845655527
BXD40 m 19.7755 4.6941534118 29.0695970662 10.4814029338
BXD43 m 1.667482 4.1985784502 9.9803751318 -6.6454111318
BXD45 m 8.3208 4.1985784502 16.6336931318 0.0079068682
BXD48 m 11.6724 4.1985784502 19.9852931318 3.3595068682
BXD48a m 16.591 4.6941534118 25.8850970662 7.2969029338
BXD49 m 5.0644 4.1985784502 13.3772931318 -3.2484931318
BXD51 m 7.3493 5.4203414718 18.081198886 -3.382598886
BXD53 m 6.0764 4.1985784502 14.3892931318 -2.2364931318
BXD55 m 2.6656 4.1985784502 10.9784931318 -5.6472931318
BXD6 m 6.55726 4.1985784502 14.8701531318 -1.7556331318
BXD62 m 1.001 4.6941534118 10.2950970662 -8.2930970662
BXD63 m 9.8956 4.1985784502 18.2084931318 1.5827068682
BXD64 m 14.73 4.1985784502 23.0428931318 6.4171068682
BXD66 m 5.5173333333 5.4203414718 16.2492322194 -5.2145655527
BXD67 m 4.064 4.1985784502 12.3768931318 -4.2488931318
BXD69 m 30.0765 4.6941534118 39.3705970662 20.7824029338
BXD73 m 7.684 5.4203414718 18.415898886 -3.047898886
BXD75 m 15.925 4.6941534118 25.2190970662 6.6309029338
BXD77 m 8.4864 4.1985784502 16.7992931318 0.1735068682
BXD79 m 10.6204 4.1985784502 18.9332931318 2.3075068682
BXD8 m 5.576 6.6385354188 18.719838121 -7.567838121
BXD81 m 24.384 4.1985784502 32.6968931318 16.0711068682
BXD84 m 35.8132 4.1985784502 44.1260931318 27.5003068682
BXD87 m 3.4365 4.6941534118 12.7305970662 -5.8575970662
BXD89 m 18.4752 4.1985784502 26.7880931318 10.1623068682
BXD90 m 4.062975 4.6941534118 13.3570720662 -5.2311220662
C57BL/6J m 31.0466666667 5.4203414718 41.7785655527 20.3147677806
DBA/2J m 6.0795333333 5.4203414718 16.8114322194 -4.6523655527




  GWAS USING LINEAR MIXED MODELS