Project measure / variable:   Schoonjans1   TCA_plasma_t30_HFD

ID, description, units MPD:112705   TCA_plasma_t30_HFD   plasma bile acid taurocholic acid amount, glucose kinetic test, at 20 wks of age, after 30 min   [ng/mL]  HFD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 20wks
Procedure biomarker quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Schoonjans1 - plasma bile acid taurocholic acid amount, glucose kinetic test, at 20 wks of age, after 30 min HFD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means246.8   ng/mL
Median of the strain means190.9   ng/mL
SD of the strain means± 166.2
Coefficient of variation (CV)0.6736
Min–max range of strain means75.94   –   786.5   ng/mL
Mean sample size per strain4.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 3677177.6578 105062.2188 2.6288 < 0.0001
Residuals 122 4875891.9823 39966.3277


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 94.37 65.31   5 29.208 0.6921 35.662, 199.4 -0.92
BXD100 m 212.4 165.0   9 55.0 0.777 34.66, 552.1 -0.21
BXD11 m 148.5 55.06   3 31.786 0.3707 106.3, 210.8 -0.59
BXD12 m 323.2 419.9   4 209.9 1.299 49.912, 947.5 0.46
BXD27 m 334.9 171.3   5 76.59 0.5115 161.7, 561.5 0.53
BXD32 m 192.2 124.3   4 62.16 0.6469 109.5, 376.9 -0.33
BXD34 m 190.9 122.0   4 60.98 0.6388 79.45, 301.3 -0.34
BXD39 m 226.0 196.1   3 113.2 0.8677 46.38, 435.2 -0.12
BXD40 m 259.2 162.7   4 81.33 0.6276 149.6, 500.1 0.07
BXD43 m 129.7 19.777   5 8.8445 0.1525 100.9, 147.5 -0.7
BXD45 m 87.82 41.421   5 18.524 0.4717 47.004, 153.9 -0.96
BXD48 m 157.8 73.16   5 32.719 0.4636 80.75, 248.5 -0.54
BXD48a m 540.1 82.68   4 41.339 0.1531 419.1, 597.7 1.77
BXD49 m 75.94 18.022   5 8.0595 0.2373 51.54, 93.35 -1.03
BXD51 m 491.2 249.1   3 143.8 0.507 297.9, 772.3 1.47
BXD53 m 154.9 100.7   5 45.016 0.6498 65.05, 293.6 -0.55
BXD55 m 120.7 12.719   5 5.688 0.1054 106.1, 132.4 -0.76
BXD6 m 331.6 225.1   5 100.7 0.6788 137.9, 668.1 0.51
BXD62 m 147.2 55.61   4 27.805 0.3778 76.69, 211.3 -0.6
BXD63 m 214.6 67.63   5 30.244 0.3151 145.7, 293.6 -0.19
BXD64 m 343.9 90.86   5 40.634 0.2642 244.1, 440.6 0.58
BXD66 m 90.57 64.19   3 37.061 0.7087 41.43, 163.2 -0.94
BXD67 m 164.8 57.23   5 25.594 0.3474 100.4, 244.5 -0.49
BXD69 m 556.4 493.7   4 246.8 0.8873 80.28, 1230.0 1.86
BXD73 m 92.52 51.09   3 29.499 0.5523 61.88, 151.5 -0.93
BXD75 m 474.3 368.7   4 184.3 0.7774 151.2, 813.1 1.37
BXD77 m 191.0 41.235   5 18.441 0.2159 122.8, 228.1 -0.34
BXD79 m 330.8 458.1   5 204.9 1.3849 97.07, 1149.0 0.51
BXD8 m 155.4 113.0   3 65.22 0.7271 53.08, 276.6 -0.55
BXD81 m 390.1 284.9   5 127.4 0.7302 202.1, 872.2 0.86
BXD84 m 426.3 352.7   5 157.8 0.8275 141.8, 1017.0 1.08
BXD87 m 100.4 34.507   4 17.253 0.3438 72.39, 150.7 -0.88
BXD89 m 97.75 75.79   5 33.894 0.7753 47.958, 230.7 -0.9
BXD90 m 123.0 111.4   4 55.72 0.9062 49.258, 287.6 -0.74
C57BL/6J m 786.5 393.6   3 227.2 0.5004 394.9, 1182.0 3.25
DBA/2J m 126.1 118.7   3 68.53 0.941 31.74, 259.4 -0.73


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 94.3708 89.4050644246 271.3570546709 -82.6154546709
BXD100 m 212.3544444444 66.6386005287 344.2722099535 80.4366789353
BXD11 m 148.5333333333 115.421441861 377.0216056161 -79.9549389494
BXD12 m 323.228 99.957900793 521.1046482636 125.3513517363
BXD27 m 334.86 89.4050644246 511.8462546709 157.8737453291
BXD32 m 192.175 99.957900793 390.0516482636 -5.7016482637
BXD34 m 190.9225 99.957900793 388.7991482636 -6.9541482636
BXD39 m 225.9933333333 115.421441861 454.4816056161 -2.4949389494
BXD40 m 259.175 99.957900793 457.0516482636 61.2983517364
BXD43 m 129.66 89.4050644246 306.6462546709 -47.3262546709
BXD45 m 87.8168 89.4050644246 264.8030546709 -89.1694546709
BXD48 m 157.798 89.4050644246 334.7842546709 -19.1882546709
BXD48a m 540.1 99.957900793 737.9766482636 342.2233517364
BXD49 m 75.944 89.4050644246 252.9302546709 -101.0422546709
BXD51 m 491.2333333333 115.421441861 719.721605616 262.7450610506
BXD53 m 154.906 89.4050644246 331.8922546709 -22.0802546709
BXD55 m 120.72 89.4050644246 297.7062546709 -56.2662546709
BXD6 m 331.64 89.4050644246 508.6262546709 154.6537453291
BXD62 m 147.1975 99.957900793 345.0741482636 -50.6791482636
BXD63 m 214.6 89.4050644246 391.5862546709 37.6137453291
BXD64 m 343.92 89.4050644246 520.9062546709 166.9337453291
BXD66 m 90.5733333333 115.421441861 319.0616056161 -137.9149389494
BXD67 m 164.76 89.4050644246 341.7462546709 -12.2262546709
BXD69 m 556.395 99.957900793 754.2716482637 358.5183517364
BXD73 m 92.5166666667 115.421441861 321.0049389494 -135.9716056161
BXD75 m 474.275 99.957900793 672.1516482636 276.3983517364
BXD77 m 190.96 89.4050644246 367.9462546709 13.9737453291
BXD79 m 330.774 89.4050644246 507.7602546709 153.7877453291
BXD8 m 155.36 115.421441861 383.8482722827 -73.1282722827
BXD81 m 390.1 89.4050644246 567.0862546709 213.1137453291
BXD84 m 426.26 89.4050644246 603.2462546709 249.2737453291
BXD87 m 100.37 99.957900793 298.2466482636 -97.5066482636
BXD89 m 97.7496 89.4050644246 274.7358546709 -79.2366546709
BXD90 m 122.9895 99.957900793 320.8661482636 -74.8871482636
C57BL/6J m 786.5333333333 115.421441861 1015.0216056161 558.0450610506
DBA/2J m 126.1433333333 115.421441861 354.6316056161 -102.3449389494




  GWAS USING LINEAR MIXED MODELS