Project measure / variable:   Schoonjans1   TaMCA_plasma_t30_HFD

ID, description, units MPD:112701   TaMCA_plasma_t30_HFD   plasma bile acid tauro-α-muricholic acid amount, glucose kinetic test, at 20 wks of age, after 30 min   [ng/mL]  HFD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 20wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - plasma bile acid tauro-α-muricholic acid amount, glucose kinetic test, at 20 wks of age, after 30 min HFD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means67.78   ng/mL
Median of the strain means52.58   ng/mL
SD of the strain means± 41.821
Coefficient of variation (CV)0.617
Min–max range of strain means16.041   –   199.4   ng/mL
Mean sample size per strain4.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 253895.6593 7254.1617 1.8328 0.0084
Residuals 122 482875.1448 3957.993


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 21.556 17.649   5 7.893 0.8188 8.864, 51.84 -1.11
BXD100 m 45.291 40.407   9 13.469 0.8922 5.822, 136.4 -0.54
BXD11 m 52.25 17.067   3 9.8534 0.3266 42.352, 71.96 -0.37
BXD12 m 199.4 271.8   4 135.9 1.363 30.032, 604.0 3.15
BXD27 m 112.5 86.36   5 38.62 0.7678 35.502, 244.9 1.07
BXD32 m 41.759 34.066   4 17.033 0.8158 15.772, 91.32 -0.62
BXD34 m 61.88 40.577   4 20.289 0.6558 27.38, 110.6 -0.14
BXD39 m 52.01 43.945   3 25.372 0.8449 17.222, 101.4 -0.38
BXD40 m 95.94 49.598   4 24.799 0.517 64.81, 169.8 0.67
BXD43 m 22.469 3.4812   5 1.5568 0.1549 17.76, 26.746 -1.08
BXD45 m 71.37 20.747   5 9.2783 0.2907 47.272, 99.71 0.09
BXD48 m 52.91 24.429   5 10.925 0.4617 26.072, 83.31 -0.36
BXD48a m 155.8 23.999   4 12.0 0.154 122.8, 178.6 2.1
BXD49 m 34.438 12.168   5 5.4417 0.3533 24.818, 54.29 -0.8
BXD51 m 97.68 56.79   3 32.787 0.5813 59.16, 162.9 0.71
BXD53 m 42.358 16.759   5 7.4951 0.3957 22.58, 59.6 -0.61
BXD55 m 42.575 9.2827   5 4.1514 0.218 30.06, 52.09 -0.6
BXD6 m 59.26 28.999   5 12.969 0.4893 31.744, 98.66 -0.2
BXD62 m 44.147 16.325   4 8.1624 0.3698 27.634, 66.46 -0.57
BXD63 m 35.106 10.287   5 4.6003 0.293 21.326, 49.984 -0.78
BXD64 m 112.9 28.401   5 12.701 0.2516 84.76, 146.8 1.08
BXD66 m 29.633 12.71   3 7.3379 0.4289 18.288, 43.368 -0.91
BXD67 m 26.678 17.937   5 8.0215 0.6723 10.732, 57.44 -0.98
BXD69 m 134.2 114.8   4 57.38 0.8553 21.222, 290.3 1.59
BXD73 m 48.597 42.646   3 24.622 0.8776 23.786, 97.84 -0.46
BXD75 m 133.6 98.76   4 49.38 0.7392 52.4, 263.0 1.57
BXD77 m 72.06 18.662   5 8.346 0.259 45.25, 91.37 0.1
BXD79 m 77.96 93.32   5 41.734 1.1971 25.376, 243.6 0.24
BXD8 m 46.897 27.86   3 16.085 0.5941 18.048, 73.65 -0.5
BXD81 m 83.53 63.66   5 28.471 0.7622 47.062, 194.8 0.38
BXD84 m 75.93 83.7   5 37.433 1.1024 28.648, 224.7 0.19
BXD87 m 16.041 6.7776   4 3.3888 0.4225 10.084, 25.122 -1.24
BXD89 m 55.92 41.464   5 18.543 0.7415 30.166, 129.1 -0.28
BXD90 m 48.706 33.973   4 16.986 0.6975 27.606, 99.34 -0.46
C57BL/6J m 112.5 58.3   3 33.661 0.5184 60.48, 175.5 1.07
DBA/2J m 24.348 26.15   3 15.098 1.074 7.136, 54.44 -1.04


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 21.5558 28.1353620561 77.2525593075 -34.1409593075
BXD100 m 45.2906666667 20.9708607097 86.8045799794 3.776753354
BXD11 m 52.2533333333 36.3225962277 124.1575404119 -19.6508737453
BXD12 m 199.4005 31.4562910646 261.671369969 137.129630031
BXD27 m 112.4792 28.1353620561 168.1759593075 56.7824406925
BXD32 m 41.759 31.4562910646 104.029869969 -20.511869969
BXD34 m 61.8785 31.4562910646 124.149369969 -0.392369969
BXD39 m 52.0146666667 36.3225962277 123.9188737453 -19.8895404119
BXD40 m 95.9375 31.4562910646 158.208369969 33.666630031
BXD43 m 22.469 28.1353620561 78.1657593075 -33.2277593075
BXD45 m 71.3704 28.1353620561 127.0671593075 15.6736406925
BXD48 m 52.9084 28.1353620561 108.6051593075 -2.7883593075
BXD48a m 155.85 31.4562910646 218.120869969 93.579130031
BXD49 m 34.438 28.1353620561 90.1347593075 -21.2587593075
BXD51 m 97.6833333333 36.3225962277 169.5875404119 25.7791262547
BXD53 m 42.358 28.1353620561 98.0547593075 -13.3387593075
BXD55 m 42.5752 28.1353620561 98.2719593075 -13.1215593075
BXD6 m 59.2624 28.1353620561 114.9591593075 3.5656406925
BXD62 m 44.147 31.4562910646 106.417869969 -18.123869969
BXD63 m 35.1064 28.1353620561 90.8031593075 -20.5903593075
BXD64 m 112.898 28.1353620561 168.5947593075 57.2012406925
BXD66 m 29.6333333333 36.3225962277 101.5375404119 -42.2708737453
BXD67 m 26.6776 28.1353620561 82.3743593075 -29.0191593075
BXD69 m 134.1755 31.4562910646 196.446369969 71.904630031
BXD73 m 48.5966666667 36.3225962277 120.5008737453 -23.3075404119
BXD75 m 133.6025 31.4562910646 195.873369969 71.331630031
BXD77 m 72.06 28.1353620561 127.7567593075 16.3632406925
BXD79 m 77.9564 28.1353620561 133.6531593075 22.2596406925
BXD8 m 46.8973333333 36.3225962277 118.8015404119 -25.0068737453
BXD81 m 83.5268 28.1353620561 139.2235593075 27.8300406925
BXD84 m 75.928 28.1353620561 131.6247593075 20.2312406925
BXD87 m 16.0405 31.4562910646 78.311369969 -46.230369969
BXD89 m 55.9224 28.1353620561 111.6191593075 0.2256406925
BXD90 m 48.7055 31.4562910646 110.976369969 -13.565369969
C57BL/6J m 112.46 36.3225962277 184.3642070786 40.5557929214
DBA/2J m 24.348 36.3225962277 96.2522070786 -47.5562070786




  GWAS USING LINEAR MIXED MODELS