Project measure / variable:   Schoonjans1   TUDCA_plasma_t0_CD

ID, description, units MPD:112676   TUDCA_plasma_t0_CD   plasma bile acid tauroursodeoxycholic acid amount, glucose kinetic test, at 20 wks of age, at 0 min   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 20wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - plasma bile acid tauroursodeoxycholic acid amount, glucose kinetic test, at 20 wks of age, at 0 min CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means8.0703   ng/mL
Median of the strain means7.6937   ng/mL
SD of the strain means± 4.4785
Coefficient of variation (CV)0.5549
Min–max range of strain means1.8243   –   19.528   ng/mL
Mean sample size per strain4.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 34 3225.3996 94.8647 4.798 < 0.0001
Residuals 124 2451.6696 19.7715


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 1.8243 0.51449   5 0.23009 0.282 1.338, 2.5676 -1.39
BXD100 m 10.134 1.5405   5 0.68892 0.152 8.424, 12.214 0.46
BXD11 m 4.329 3.0971   4 1.5486 0.7154 1.366, 8.684 -0.84
BXD12 m 13.552 7.4005   3 4.2727 0.5461 7.952, 21.942 1.22
BXD27 m 8.368 0.0   1   0.0 0.0 8.368, 8.368 0.07
BXD32 m 4.1792 2.4648   5 1.1023 0.5898 1.962, 7.986 -0.87
BXD34 m 3.5856 2.0038   5 0.89614 0.5589 1.126, 5.778 -1.0
BXD39 m 3.6427 1.2206   3 0.70469 0.3351 2.234, 4.386 -0.99
BXD40 m 13.085 5.4938   4 2.7469 0.4198 6.634, 19.074 1.12
BXD43 m 3.1586 2.1249   7 0.80312 0.6727 0.642, 5.874 -1.1
BXD45 m 17.67 8.7394   4 4.3697 0.4946 11.052, 30.212 2.14
BXD48 m 9.0208 2.5778   5 1.1528 0.2858 6.68, 13.082 0.21
BXD48a m 10.972 2.9095   4 1.4548 0.2652 8.434, 14.834 0.65
BXD49 m 11.506 2.9031   5 1.2983 0.2523 8.64, 15.728 0.77
BXD51 m 8.33 3.4876   5 1.5597 0.4187 3.976, 13.39 0.06
BXD53 m 10.272 8.1527   4 4.0764 0.7937 4.224, 22.252 0.49
BXD55 m 3.6612 0.55209   5 0.2469 0.1508 2.856, 4.266 -0.98
BXD6 m 15.994 6.9147   5 3.0923 0.4323 8.812, 23.798 1.77
BXD62 m 10.472 4.3516   5 1.9461 0.4155 6.414, 17.096 0.54
BXD63 m 3.4855 0.53994   4 0.26997 0.1549 3.15, 4.286 -1.02
BXD64 m 13.2 7.338   5 3.2816 0.5559 5.154, 23.822 1.15
BXD66 m 4.484 5.5183   2   3.902 1.2307 0.582, 8.386 -0.8
BXD67 m 4.635 4.0669   4 2.0334 0.8774 1.458, 10.404 -0.77
BXD69 m 5.238 1.7537   5 0.78426 0.3348 3.346, 7.396 -0.63
BXD73 m 3.724 2.5829   4 1.2915 0.6936 1.782, 7.31 -0.97
BXD75 m 8.2174 6.6619   4 3.3309 0.8107 3.7, 17.846 0.03
BXD77 m 4.8148 2.1566   5 0.96448 0.4479 2.176, 7.88 -0.73
BXD79 m 10.634 7.3364   5 3.2809 0.6899 6.842, 23.732 0.57
BXD8 m 5.6556 3.8963   5 1.7425 0.6889 0.98, 11.192 -0.54
BXD81 m 7.17 2.1436   3 1.2376 0.299 4.7972, 8.9667 -0.2
BXD84 m 19.528 8.4909   5 3.7973 0.4348 7.702, 26.868 2.56
BXD87 m 5.2092 1.2813   5 0.573 0.246 3.168, 6.516 -0.64
BXD89 m 4.2413 2.9991   6 1.2244 0.7071 2.23, 10.05 -0.85
BXD90 m 11.13 5.4156   5 2.4219 0.4866 4.934, 18.654 0.68
C57BL/6J m 10.685 4.113   5 1.8394 0.3849 5.788, 16.996 0.58
DBA/2J m 4.7215 2.5973   4 1.2986 0.5501 2.376, 7.092 -0.75


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 1.82432 1.9885436322 5.7602048723 -2.1115648723
BXD100 m 10.134 1.9885436322 14.0698848723 6.1981151277
BXD11 m 4.329 2.2232593689 8.729453063 -0.071453063
BXD12 m 13.552 2.5671987903 18.633205521 8.470794479
BXD32 m 4.1792 1.9885436322 8.1150848723 0.2433151277
BXD34 m 3.5856 1.9885436322 7.5214848723 -0.3502848723
BXD39 m 3.6426666667 2.5671987903 8.7238721876 -1.4385388543
BXD40 m 13.0855 2.2232593689 17.485953063 8.685046937
BXD43 m 3.1585714286 1.6806261115 6.4850012745 -0.1678584174
BXD45 m 17.6705 2.2232593689 22.070953063 13.270046937
BXD48 m 9.0208 1.9885436322 12.9566848723 5.0849151277
BXD48a m 10.9715 2.2232593689 15.371953063 6.571046937
BXD49 m 11.5056 1.9885436322 15.4414848723 7.5697151277
BXD51 m 8.33 1.9885436322 12.2658848723 4.3941151277
BXD53 m 10.272 2.2232593689 14.672453063 5.871546937
BXD55 m 3.6612 1.9885436322 7.5970848723 -0.2746848723
BXD6 m 15.9936 1.9885436322 19.9294848723 12.0577151277
BXD62 m 10.472 1.9885436322 14.4078848723 6.5361151277
BXD63 m 3.4855 2.2232593689 7.885953063 -0.914953063
BXD64 m 13.2004 1.9885436322 17.1362848723 9.2645151277
BXD66 m 4.484 3.1441635522 10.7071804023 -1.7391804023
BXD67 m 4.635 2.2232593689 9.035453063 0.234546937
BXD69 m 5.238 1.9885436322 9.1738848723 1.3021151277
BXD73 m 3.724 2.2232593689 8.124453063 -0.676453063
BXD75 m 8.21745 2.2232593689 12.617903063 3.816996937
BXD77 m 4.8148 1.9885436322 8.7506848723 0.8789151277
BXD79 m 10.6344 1.9885436322 14.5702848723 6.6985151277
BXD8 m 5.6556 1.9885436322 9.5914848723 1.7197151277
BXD81 m 7.1699666667 2.5671987903 12.2511721876 2.0887611457
BXD84 m 19.5284 1.9885436322 23.4642848723 15.5925151277
BXD87 m 5.2092 1.9885436322 9.1450848723 1.2733151277
BXD89 m 4.2413333333 1.8152836733 7.8342882138 0.6483784529
BXD90 m 11.1304 1.9885436322 15.0662848723 7.1945151277
C57BL/6J m 10.6848 1.9885436322 14.6206848723 6.7489151277
DBA/2J m 4.7215 2.2232593689 9.121953063 0.321046937




  GWAS USING LINEAR MIXED MODELS