Project measure / variable:   Schoonjans1   bMCA_plasma_t0_CD

ID, description, units MPD:112652   bMCA_plasma_t0_CD   plasma bile acid β-muricholic acid amount, glucose kinetic test, at 20 wks of age, at 0 min   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 20wks
Procedure biomarker quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Schoonjans1 - plasma bile acid β-muricholic acid amount, glucose kinetic test, at 20 wks of age, at 0 min CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means51.11   ng/mL
Median of the strain means41.194   ng/mL
SD of the strain means± 46.243
Coefficient of variation (CV)0.9048
Min–max range of strain means5.7315   –   205.6   ng/mL
Mean sample size per strain4.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 359694.2941 10276.9798 2.3295 0.0003
Residuals 131 577933.1154 4411.7032


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 42.885 90.46   5 40.454 2.1093 1.788, 204.7 -0.18
BXD100 m 6.9972 7.7056   5 3.4461 1.1012 3.264, 20.778 -0.95
BXD11 m 42.173 23.055   4 11.527 0.5467 22.642, 75.55 -0.19
BXD12 m 17.269 15.089   3 8.7115 0.8737 3.31, 33.278 -0.73
BXD27 m 108.5 90.18   4 45.088 0.8313 42.586, 241.8 1.24
BXD32 m 65.59 85.81   5 38.376 1.3083 13.584, 215.1 0.31
BXD34 m 118.2 103.2   5 46.138 0.8731 10.066, 263.0 1.45
BXD39 m 50.84 76.31   3 44.06 1.5011 4.01, 138.9 -0.01
BXD40 m 133.9 95.88   4 47.942 0.7162 16.54, 240.8 1.79
BXD43 m 12.39 11.059   7 4.1798 0.8926 2.822, 34.262 -0.84
BXD45 m 40.215 51.44   4 25.722 1.2792 3.418, 113.9 -0.24
BXD48 m 13.003 11.568   5 5.1735 0.8896 4.744, 32.85 -0.82
BXD48a m 17.058 6.51   4 3.255 0.3816 9.062, 22.854 -0.74
BXD49 m 85.95 107.3   5 48.006 1.2489 1.92, 245.1 0.75
BXD51 m 9.11 10.609   5 4.7443 1.1645 1.47, 27.59 -0.91
BXD53 m 42.562 74.58   4 37.289 1.7522 2.942, 154.4 -0.18
BXD55 m 48.436 54.67   5 24.451 1.1288 10.526, 144.5 -0.06
BXD6 m 205.6 178.8   5 79.96 0.8697 40.946, 429.2 3.34
BXD62 m 57.29 37.033   5 16.562 0.6464 21.132, 117.6 0.13
BXD63 m 5.7315 2.0454   4 1.0227 0.3569 3.362, 7.896 -0.98
BXD64 m 33.152 14.68   5 6.5651 0.4428 16.684, 49.814 -0.39
BXD66 m 16.697 8.7175   5 3.8986 0.5221 7.54, 27.212 -0.74
BXD67 m 23.725 16.609   4 8.3046 0.7001 9.18, 46.99 -0.59
BXD69 m 7.426 1.9016   5 0.85042 0.2561 5.008, 9.456 -0.94
BXD73 m 86.53 92.64   4 46.32 1.0706 4.594, 172.3 0.77
BXD75 m 58.44 19.948   5 8.9212 0.3414 34.364, 86.5 0.16
BXD77 m 74.51 37.353   5 16.705 0.5013 17.366, 120.9 0.51
BXD79 m 16.528 6.2645   5 2.8016 0.379 5.68, 21.614 -0.75
BXD8 m 19.622 11.591   5 5.1837 0.5907 9.014, 37.91 -0.68
BXD81 m 33.63 23.115   3 13.345 0.6873 17.983, 60.18 -0.38
BXD84 m 11.658 6.1069   5 2.7311 0.5238 4.382, 21.23 -0.85
BXD87 m 114.2 139.8   5 62.53 1.2239 34.348, 363.7 1.36
BXD89 m 17.884 22.325   6 9.1141 1.2483 1.726, 61.11 -0.72
BXD90 m 13.187 23.662   5 10.582 1.7943 1.998, 55.5 -0.82
C57BL/6J m 134.1 113.0   5 50.55 0.8429 6.932, 282.4 1.79
DBA/2J m 54.85 78.49   4 39.244 1.4309 7.888, 172.2 0.08


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 42.8852 29.7042191324 101.6472310654 -15.8768310654
BXD100 m 6.9972 29.7042191324 65.7592310654 -51.7648310654
BXD11 m 42.1735 33.2103265993 107.8714479791 -23.5244479791
BXD12 m 17.2693333333 38.347982004 93.1307892353 -58.5921225686
BXD27 m 108.469 33.2103265993 174.1669479791 42.7710520209
BXD32 m 65.5896 29.7042191324 124.3516310654 6.8275689346
BXD34 m 118.1632 29.7042191324 176.9252310654 59.4011689346
BXD39 m 50.8386666667 38.347982004 126.7001225686 -25.0227892353
BXD40 m 133.885 33.2103265993 199.5829479791 68.1870520209
BXD43 m 12.3897142857 25.1046471831 62.0526948572 -37.2732662857
BXD45 m 40.215 33.2103265993 105.9129479791 -25.4829479791
BXD48 m 13.0032 29.7042191324 71.7652310654 -45.7588310654
BXD48a m 17.0585 33.2103265993 82.7564479791 -48.6394479791
BXD49 m 85.9536 29.7042191324 144.7156310654 27.1915689346
BXD51 m 9.11 29.7042191324 67.8720310654 -49.6520310654
BXD53 m 42.562 33.2103265993 108.2599479791 -23.1359479791
BXD55 m 48.4364 29.7042191324 107.1984310654 -10.3256310654
BXD6 m 205.5832 29.7042191324 264.3452310654 146.8211689346
BXD62 m 57.2912 29.7042191324 116.0532310654 -1.4708310654
BXD63 m 5.7315 33.2103265993 71.4294479791 -59.9664479791
BXD64 m 33.1516 29.7042191324 91.9136310654 -25.6104310654
BXD66 m 16.6968 29.7042191324 75.4588310654 -42.0652310654
BXD67 m 23.725 33.2103265993 89.4229479791 -41.9729479791
BXD69 m 7.426 29.7042191324 66.1880310654 -51.3360310654
BXD73 m 86.5305 33.2103265993 152.2284479791 20.8325520209
BXD75 m 58.4374 29.7042191324 117.1994310654 -0.3246310654
BXD77 m 74.5112 29.7042191324 133.2732310654 15.7491689346
BXD79 m 16.528 29.7042191324 75.2900310654 -42.2340310654
BXD8 m 19.622 29.7042191324 78.3840310654 -39.1400310654
BXD81 m 33.6303333333 38.347982004 109.4917892353 -42.2311225686
BXD84 m 11.6582 29.7042191324 70.4202310654 -47.1038310654
BXD87 m 114.2496 29.7042191324 173.0116310654 55.4875689346
BXD89 m 17.8843333333 27.1161181198 71.5264832323 -35.7578165656
BXD90 m 13.1868 29.7042191324 71.9488310654 -45.5752310654
C57BL/6J m 134.0892 29.7042191324 192.8512310654 75.3271689346
DBA/2J m 54.8515 33.2103265993 120.5494479791 -10.8464479791




  GWAS USING LINEAR MIXED MODELS