Project measure / variable:   Auwerx1   ogtt_gluc_auc_HFD

ID, description, units MPD:111263   ogtt_gluc_auc_HFD   glucose, area under curve, glucose tolerance test (20% glucose oral gavage, overnight fast)   [AUC]  HFD  
high-fat diet study
Data set, strains Auwerx1   BXD w/par   56 strains     sex: m     age: 17wks
Procedure glucose tolerance
Ontology mappings

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  STRAIN COMPARISON PLOT
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Auwerx1 - glucose, area under curve, glucose tolerance test (20% glucose oral gavage, overnight fast) HFD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested56 strains
Mean of the strain means54129.0   AUC
Median of the strain means49258.0   AUC
SD of the strain means± 16349.0
Coefficient of variation (CV)0.302
Min–max range of strain means31812.0   –   92703.0   AUC
Mean sample size per strain4.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 55 69614712870.9994 1265722052.2 15.3446 < 0.0001
Residuals 192 15837390608.8555 82486409.4211


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 44798.0 8511.0   5 3806.0 0.19 35325.0, 56580.0 -0.57
BXD100 m 49158.0 9417.0   5 4211.0 0.1916 39495.0, 63938.0 -0.3
BXD101 m 35706.0 2321.0   4 1160.0 0.065 34058.0, 39105.0 -1.13
BXD11 m 41367.0 8794.0   5 3933.0 0.2126 29550.0, 48218.0 -0.78
BXD12 m 36623.0 5765.0   5 2578.0 0.1574 31350.0, 45975.0 -1.07
BXD16 m 61356.0 9071.0   5 4057.0 0.1478 51840.0, 70958.0 0.44
BXD2 m 35216.0 5154.0   5 2305.0 0.1463 29640.0, 40523.0 -1.16
BXD27 m 72093.0 7337.0   4 3668.0 0.1018 64103.0, 79418.0 1.1
BXD32 m 47758.0 20807.0   3 12013.0 0.4357 33848.0, 71678.0 -0.39
BXD34 m 41517.0 7512.0   5 3360.0 0.1809 29528.0, 48023.0 -0.77
BXD39 m 86435.0 7002.0   5 3131.0 0.081 78533.0, 92760.0 1.98
BXD40 m 44246.0 2051.0   4 1026.0 0.0464 42060.0, 46328.0 -0.6
BXD43 m 57433.0 2770.0   3 1599.0 0.0482 54600.0, 60135.0 0.2
BXD44 m 91134.0 7950.0   9 2650.0 0.0872 72540.0, 98745.0 2.26
BXD45 m 42535.0 2433.0   4 1217.0 0.0572 39398.0, 45233.0 -0.71
BXD48 m 59689.0 10734.0   4 5367.0 0.1798 46538.0, 72600.0 0.34
BXD48a m 64988.0 20483.0   3 11826.0 0.3152 41573.0, 79590.0 0.66
BXD49 m 36531.0 5665.0   4 2833.0 0.1551 32100.0, 44198.0 -1.08
BXD50 m 41021.0 3331.0   5 1490.0 0.0812 36945.0, 44160.0 -0.8
BXD51 m 47676.0 6728.0   4 3364.0 0.1411 38610.0, 54870.0 -0.39
BXD53 m 57240.0 13822.0   5 6181.0 0.2415 43515.0, 79605.0 0.19
BXD55 m 31812.0 2113.0   4 1057.0 0.0664 29115.0, 34238.0 -1.37
BXD56 m 55009.0 7912.0   4 3956.0 0.1438 47760.0, 64620.0 0.05
BXD6 m 42365.0 2199.0   5 983.5 0.0519 40635.0, 46035.0 -0.72
BXD60 m 50111.0 2964.0   5 1326.0 0.0592 47153.0, 54248.0 -0.25
BXD61 m 42864.0 10244.0   5 4581.0 0.239 33270.0, 58973.0 -0.69
BXD62 m 50864.0 16489.0   4 8245.0 0.3242 35783.0, 74363.0 -0.2
BXD63 m 80500.0 7776.0   4 3888.0 0.0966 69878.0, 88583.0 1.61
BXD64 m 76776.0 10645.0   4 5323.0 0.1387 64568.0, 88185.0 1.39
BXD65 m 56012.0 14202.0   4 7101.0 0.2536 42443.0, 69360.0 0.12
BXD65a m 59021.0 8237.0   4 4119.0 0.1396 50925.0, 69660.0 0.3
BXD66 m 34339.0 2267.0   4 1133.0 0.066 31943.0, 37395.0 -1.21
BXD67 m 57719.0 5150.0   5 2303.0 0.0892 54315.0, 66750.0 0.22
BXD68 m 52472.0 9816.0   4 4908.0 0.1871 40020.0, 60345.0 -0.1
BXD69 m 87212.0 4505.0   5 2015.0 0.0517 80888.0, 91493.0 2.02
BXD70 m 41760.0 13534.0   4 6767.0 0.3241 28928.0, 58950.0 -0.76
BXD71 m 81873.0 16554.0   3 9557.0 0.2022 62993.0, 93900.0 1.7
BXD73 m 44394.0 5364.0   5 2399.0 0.1208 39135.0, 50858.0 -0.6
BXD73a m 41216.0 3760.0   4 1880.0 0.0912 37268.0, 46275.0 -0.79
BXD73b m 42630.0 9985.0   5 4465.0 0.2342 32490.0, 56955.0 -0.7
BXD75 m 49358.0 10714.0   5 4791.0 0.2171 38715.0, 64710.0 -0.29
BXD77 m 61893.0 10950.0   5 4897.0 0.1769 43208.0, 69420.0 0.47
BXD79 m 59870.0 14384.0   5 6433.0 0.2403 41633.0, 77610.0 0.35
BXD8 m 37905.0 7075.0   5 3164.0 0.1867 30570.0, 48060.0 -0.99
BXD81 m 71567.0 6475.0   4 3238.0 0.0905 64050.0, 79808.0 1.07
BXD83 m 48199.0 11887.0   4 5943.0 0.2466 37830.0, 62460.0 -0.36
BXD84 m 81533.0 10163.0   3 5868.0 0.1246 70643.0, 90765.0 1.68
BXD85 m 78105.0 14576.0   4 7288.0 0.1866 63480.0, 92093.0 1.47
BXD87 m 47882.0 9561.0   5 4276.0 0.1997 37125.0, 62453.0 -0.38
BXD89 m 33370.0 8614.0   4 4307.0 0.2581 20798.0, 39428.0 -1.27
BXD90 m 39758.0 2279.0   4 1139.0 0.0573 38040.0, 43095.0 -0.88
BXD95 m 57942.0 8317.0   5 3720.0 0.1435 49373.0, 70148.0 0.23
BXD98 m 92703.0 5021.0   5 2245.0 0.0542 84368.0, 97215.0 2.36
BXD99 m 63851.0 11458.0   5 5124.0 0.1794 45690.0, 77235.0 0.59
C57BL/6J m 46844.0 6747.0   4 3373.0 0.144 42094.0, 56670.0 -0.45
DBA/2J m 36968.0 7182.0   3 4146.0 0.1943 30630.0, 44768.0 -1.05


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 44797.5999999998 4061.6846116143 52808.8524767784 36786.3475232213
BXD100 m 49158.2000000002 4061.6846116143 57169.4524767788 41146.9475232216
BXD101 m 35705.7499999996 4541.1014473673 44662.602561495 26748.8974385043
BXD11 m 41367.4000000001 4061.6846116143 49378.6524767787 33356.1475232215
BXD12 m 36622.5999999999 4061.6846116143 44633.8524767785 28611.3475232214
BXD16 m 61356.2000000001 4061.6846116143 69367.4524767787 53344.9475232216
BXD2 m 35215.8000000001 4061.6846116143 43227.0524767786 27204.5475232215
BXD27 m 72093.2500000008 4541.1014473673 81050.1025614961 63136.3974385055
BXD32 m 47757.9999999999 5243.6122861097 58100.482474942 37415.5175250579
BXD34 m 41517.4 4061.6846116143 49528.6524767786 33506.1475232214
BXD39 m 86434.5999999998 4061.6846116143 94445.8524767783 78423.3475232213
BXD40 m 44246.5000000001 4541.1014473673 53203.3525614954 35289.6474385049
BXD43 m 57432.6666666667 5243.6122861097 67775.1491416088 47090.1841917246
BXD44 m 91134.4444444447 3027.4009649115 97105.6794854415 85163.2094034479
BXD45 m 42534.7499999999 4541.1014473672 51491.6025614951 33577.8974385047
BXD48 m 59688.9999999998 4541.1014473672 68645.8525614949 50732.1474385046
BXD48a m 64987.6666666667 5243.6122861097 75330.1491416088 54645.1841917246
BXD49 m 36530.75 4541.1014473672 45487.6025614952 27573.8974385048
BXD50 m 41020.7999999999 4061.6846116143 49032.0524767784 33009.5475232214
BXD51 m 47675.7500000001 4541.1014473672 56632.6025614953 38718.8974385048
BXD53 m 57240.1999999999 4061.6846116143 65251.4524767784 49228.9475232214
BXD55 m 31811.4999999999 4541.1014473672 40768.3525614951 22854.6474385047
BXD56 m 55008.75 4541.1014473672 63965.6025614952 46051.8974385048
BXD6 m 42364.8000000001 4061.6846116143 50376.0524767787 34353.5475232215
BXD60 m 50110.8 4061.6846116143 58122.0524767786 42099.5475232215
BXD61 m 42864.4 4061.6846116143 50875.6524767786 34853.1475232214
BXD62 m 50863.5 4541.1014473672 59820.3525614952 41906.6474385048
BXD63 m 80499.7499999994 4541.1014473672 89456.6025614945 71542.8974385043
BXD64 m 76775.9999999995 4541.1014473672 85732.8525614947 67819.1474385044
BXD65 m 56011.9999999998 4541.1014473672 64968.852561495 47055.1474385047
BXD65a m 59021.25 4541.1014473672 67978.1025614952 50064.3974385048
BXD66 m 34339.0 4541.1014473672 43295.8525614951 25382.1474385048
BXD67 m 57718.5999999999 4061.6846116143 65729.8524767784 49707.3475232213
BXD68 m 52471.9999999999 4541.1014473672 61428.852561495 43515.1474385047
BXD69 m 87212.0000000001 4061.6846116143 95223.2524767786 79200.7475232215
BXD70 m 41760.25 4541.1014473672 50717.1025614952 32803.3974385048
BXD71 m 81872.6666666667 5243.6122861097 92215.1491416088 71530.1841917246
BXD73 m 44394.4 4061.6846116143 52405.6524767785 36383.1475232214
BXD73a m 41216.5 4541.1014473672 50173.3525614952 32259.6474385048
BXD73b m 42630.0 4061.6846116143 50641.2524767785 34618.7475232214
BXD75 m 49357.8 4061.6846116143 57369.0524767786 41346.5475232215
BXD77 m 61893.2 4061.6846116143 69904.4524767786 53881.9475232215
BXD79 m 59869.8 4061.6846116143 67881.0524767785 51858.5475232214
BXD8 m 37905.2 4061.6846116143 45916.4524767785 29893.9475232214
BXD81 m 71567.25 4541.1014473672 80524.1025614952 62610.3974385048
BXD83 m 48199.0 4541.1014473672 57155.8525614952 39242.1474385048
BXD84 m 81532.6666666666 5243.6122861097 91875.1491416087 71190.1841917246
BXD85 m 78105.2500000001 4541.1014473672 87062.1025614953 69148.3974385049
BXD87 m 47881.6 4061.6846116143 55892.8524767785 39870.3475232214
BXD89 m 33369.75 4541.1014473672 42326.6025614952 24412.8974385048
BXD90 m 39757.75 4541.1014473672 48714.6025614952 30800.8974385048
BXD95 m 57942.3999999999 4061.6846116143 65953.6524767785 49931.1475232214
BXD98 m 92703.1999999999 4061.6846116143 100714.4524767785 84691.9475232214
BXD99 m 63850.6 4061.6846116143 71861.8524767785 55839.3475232214
C57BL/6J m 46844.25 4541.1014473672 55801.1025614952 37887.3974385048
DBA/2J m 36967.6666666666 5243.6122861097 47310.1491416087 26625.1841917246




  GWAS USING LINEAR MIXED MODELS