ITP survival analysis: b-guanidinopropionic acid
Intervention:
b-guanidinopropionic acid
dietary supplement
Trial code: bGPA
Dose: 3300 ppm
initiated at age: 6 mo
Sex: both
Cohort: C2015
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
bGPA effect on survival,
females, test site = All
Log-rank test
chisq = 0.0134
p = 0.9079
Wang-Allison test
odds ratio = 1.2191
p = 0.6082
Quantiles
bGPA
Control
% difference
25% died before day:
758
786
-4 %
Median lifespan (days)
892
904
-1 %
75% died before day:
1016
1016
0 %
90% died before day:
1114
1095
+2 %
Max lifespan observed (days)
1272
1396
Number of mice at start
136
274
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
bGPA effect on survival,
males, test site = All
Log-rank test
chisq = 0.1153
p = 0.7342
Wang-Allison test
odds ratio = 0.979
p = 1.0
Quantiles
bGPA
Control
% difference
25% died before day:
538
581
-7 %
Median lifespan (days)
764
772
-1 %
75% died before day:
916
918
0 %
90% died before day:
1054
1049
0 %
Max lifespan observed (days)
1283
1237
Number of mice at start
140
264
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
bGPA effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.5896
p = 0.4426
Wang-Allison test
odds ratio = 0.4633
p = 0.3862
Quantiles
bGPA
Control
% difference
25% died before day:
750
785
-4 %
Median lifespan (days)
954
928
+3 %
75% died before day:
1028
1043
-1 %
90% died before day:
1086
1156
-6 %
Max lifespan observed (days)
1239
1396
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
bGPA effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.1783
p = 0.6729
Wang-Allison test
odds ratio = 0.8378
p = 1.0
Quantiles
bGPA
Control
% difference
25% died before day:
598
608
-2 %
Median lifespan (days)
766
818
-6 %
75% died before day:
953
942
+1 %
90% died before day:
1057
1061
0 %
Max lifespan observed (days)
1283
1237
Number of mice at start
54
92
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
bGPA effect on survival,
females, test site = UM
Log-rank test
chisq = 0.009
p = 0.9243
Wang-Allison test
odds ratio = 1.1667
p = 0.7712
Quantiles
bGPA
Control
% difference
25% died before day:
786
791
-1 %
Median lifespan (days)
868
899
-3 %
75% died before day:
998
992
+1 %
90% died before day:
1081
1079
0 %
Max lifespan observed (days)
1246
1291
Number of mice at start
44
91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
bGPA effect on survival,
males, test site = UM
Log-rank test
chisq = 0.2198
p = 0.6392
Wang-Allison test
odds ratio = 1.2648
p = 0.7595
Quantiles
bGPA
Control
% difference
25% died before day:
500
601
-17 %
Median lifespan (days)
749
740
+1 %
75% died before day:
832
905
-8 %
90% died before day:
1046
1027
+2 %
Max lifespan observed (days)
1197
1231
Number of mice at start
41
81
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
bGPA effect on survival,
females, test site = UT
Log-rank test
chisq = 0.4483
p = 0.5031
Wang-Allison test
odds ratio = 3.0087
p = 0.0693
Quantiles
bGPA
Control
% difference
25% died before day:
755
786
-4 %
Median lifespan (days)
868
892
-3 %
75% died before day:
1043
1014
+3 %
90% died before day:
1120
1078
+4 %
Max lifespan observed (days)
1272
1280
Number of mice at start
44
88
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
bGPA effect on survival,
males, test site = UT
Log-rank test
chisq = 0.084
p = 0.772
Wang-Allison test
odds ratio = 0.9007
p = 1.0
Quantiles
bGPA
Control
% difference
25% died before day:
648
500
+30 %
Median lifespan (days)
818
786
+4 %
75% died before day:
883
888
-1 %
90% died before day:
1025
1025
0 %
Max lifespan observed (days)
1192
1220
Number of mice at start
45
91
Animal censor events are denoted by + marks in the plot
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ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions