ITP survival analysis:   ursolic acid

Intervention:   ursolic acid     reported to improve glucose tolerance and reduce obesity
Trial code: UA Dose: 2000 ppm initiated at age: 10 mo Sex: both Cohort: C2013
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
UA effect on survival, females, test site = All
Log-rank test chisq = 0.4672 p = 0.4943
Wang-Allison test odds ratio = 0.7735 p = 0.5091
Quantiles UA Control % difference
25% died before day: 777 751 +3 %
Median lifespan (days) 885 889 0 %
75% died before day: 995 976 +2 %
90% died before day: 1084 1097 -1 %
Max lifespan observed (days) 1221 1263
Number of mice at start 147 287
Animal censor events are denoted by + marks in the plot
All test sites combined – male
UA effect on survival, males, test site = All
Log-rank test chisq = 0.7855 p = 0.3755
Wang-Allison test odds ratio = 1.0369 p = 1.0
Quantiles UA Control % difference
25% died before day: 683 641 +7 %
Median lifespan (days) 883 830 +6 %
75% died before day: 997 968 +3 %
90% died before day: 1092 1089 0 %
Max lifespan observed (days) 1285 1294
Number of mice at start 151 273
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
UA effect on survival, females, test site = TJL
Log-rank test chisq = 0.7489 p = 0.3868
Wang-Allison test odds ratio = 0.4689 p = 0.386
Quantiles UA Control % difference
25% died before day: 788 773 +2 %
Median lifespan (days) 880 890 -1 %
75% died before day: 972 984 -1 %
90% died before day: 1054 1104 -5 %
Max lifespan observed (days) 1139 1263
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
UA effect on survival, males, test site = TJL
Log-rank test chisq = 2.2907 p = 0.1302
Wang-Allison test odds ratio = 1.6679 p = 0.3982
Quantiles UA Control % difference
25% died before day: 648 578 +12 %
Median lifespan (days) 905 802 +13 %
75% died before day: 998 939 +6 %
90% died before day: 1113 1037 +7 %
Max lifespan observed (days) 1274 1294
Number of mice at start 53 96
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
UA effect on survival, females, test site = UM
Log-rank test chisq = 0.0 p = 0.997
Wang-Allison test odds ratio = 0.9244 p = 1.0
Quantiles UA Control % difference
25% died before day: 777 757 +3 %
Median lifespan (days) 874 870 0 %
75% died before day: 985 979 +1 %
90% died before day: 1086 1097 -1 %
Max lifespan observed (days) 1167 1218
Number of mice at start 51 95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
UA effect on survival, males, test site = UM
Log-rank test chisq = 0.0 p = 0.9974
Wang-Allison test odds ratio = 0.6842 p = 0.7644
Quantiles UA Control % difference
25% died before day: 799 743 +8 %
Median lifespan (days) 923 912 +1 %
75% died before day: 1035 1079 -4 %
90% died before day: 1112 1158 -4 %
Max lifespan observed (days) 1285 1268
Number of mice at start 47 75
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
UA effect on survival, females, test site = UT
Log-rank test chisq = 3.9026 p = 0.0482
Wang-Allison test odds ratio = 1.0 p = 1.0
Quantiles UA Control % difference
25% died before day: 770 741 +4 %
Median lifespan (days) 928 897 +3 %
75% died before day: 1011 973 +4 %
90% died before day: 1157 1096 +6 %
Max lifespan observed (days) 1221 1190
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
UA effect on survival, males, test site = UT
Log-rank test chisq = 0.0021 p = 0.9632
Wang-Allison test odds ratio = 0.8998 p = 1.0
Quantiles UA Control % difference
25% died before day: 576 623 -8 %
Median lifespan (days) 806 807 0 %
75% died before day: 940 938 0 %
90% died before day: 1051 1066 -1 %
Max lifespan observed (days) 1142 1204
Number of mice at start 51 102
Animal censor events are denoted by + marks in the plot


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Statistical definitions