ITP survival analysis: TM5441
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
TM5441 effect on survival,
females, test site = All
Log-rank test
chisq = 0.9693
p = 0.3249
Wang-Allison test
odds ratio = 0.781
p = 0.6067
Quantiles
TM5441
Control
% difference
25% died before day:
764
764
0 %
Median lifespan (days)
894
897
0 %
75% died before day:
992
1018
-3 %
90% died before day:
1103
1109
-1 %
Max lifespan observed (days)
1212
1358
Number of mice at start
135
279
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
TM5441 effect on survival,
males, test site = All
Log-rank test
chisq = 0.1589
p = 0.6902
Wang-Allison test
odds ratio = 1.5761
p = 0.1703
Quantiles
TM5441
Control
% difference
25% died before day:
666
638
+4 %
Median lifespan (days)
802
832
-4 %
75% died before day:
944
969
-3 %
90% died before day:
1079
1059
+2 %
Max lifespan observed (days)
1244
1272
Number of mice at start
144
273
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
TM5441 effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.0077
p = 0.9301
Wang-Allison test
odds ratio = 1.3778
p = 0.5725
Quantiles
TM5441
Control
% difference
25% died before day:
784
782
0 %
Median lifespan (days)
893
904
-1 %
75% died before day:
970
1010
-4 %
90% died before day:
1160
1099
+6 %
Max lifespan observed (days)
1212
1358
Number of mice at start
48
96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
TM5441 effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.4125
p = 0.5207
Wang-Allison test
odds ratio = 1.2932
p = 0.7589
Quantiles
TM5441
Control
% difference
25% died before day:
644
572
+13 %
Median lifespan (days)
818
873
-6 %
75% died before day:
948
992
-4 %
90% died before day:
1086
1068
+2 %
Max lifespan observed (days)
1148
1272
Number of mice at start
48
93
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
TM5441 effect on survival,
females, test site = UM
Log-rank test
chisq = 1.8189
p = 0.1774
Wang-Allison test
odds ratio = 0.1443
p = 0.0366
Quantiles
TM5441
Control
% difference
25% died before day:
750
748
0 %
Median lifespan (days)
870
884
-2 %
75% died before day:
992
1016
-2 %
90% died before day:
1040
1139
-9 %
Max lifespan observed (days)
1103
1210
Number of mice at start
43
91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
TM5441 effect on survival,
males, test site = UM
Log-rank test
chisq = 0.4105
p = 0.5217
Wang-Allison test
odds ratio = 0.8143
p = 1.0
Quantiles
TM5441
Control
% difference
25% died before day:
690
756
-9 %
Median lifespan (days)
822
894
-8 %
75% died before day:
940
1009
-7 %
90% died before day:
1078
1084
-1 %
Max lifespan observed (days)
1244
1206
Number of mice at start
45
84
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
TM5441 effect on survival,
females, test site = UT
Log-rank test
chisq = 0.2677
p = 0.6049
Wang-Allison test
odds ratio = 1.1808
p = 0.7697
Quantiles
TM5441
Control
% difference
25% died before day:
746
768
-3 %
Median lifespan (days)
906
882
+3 %
75% died before day:
1008
1046
-4 %
90% died before day:
1122
1109
+1 %
Max lifespan observed (days)
1187
1238
Number of mice at start
44
92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
TM5441 effect on survival,
males, test site = UT
Log-rank test
chisq = 3.263
p = 0.0709
Wang-Allison test
odds ratio = 3.186
p = 0.0435
Quantiles
TM5441
Control
% difference
25% died before day:
578
570
+1 %
Median lifespan (days)
787
743
+6 %
75% died before day:
953
892
+7 %
90% died before day:
1066
977
+9 %
Max lifespan observed (days)
1132
1167
Number of mice at start
51
96
Animal censor events are denoted by + marks in the plot
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National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions