ITP survival analysis:   TM5441

Intervention:   TM5441     inhibitor of plasminogen activator inhibitor-1
Trial code: TM5441 Dose: 60 ppm initiated at age: 11 mo Sex: both Cohort: C2014
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
TM5441 effect on survival, females, test site = All
Log-rank test chisq = 0.9693 p = 0.3249
Wang-Allison test odds ratio = 0.781 p = 0.6067
Quantiles TM5441 Control % difference
25% died before day: 764 764 0 %
Median lifespan (days) 894 897 0 %
75% died before day: 992 1018 -3 %
90% died before day: 1103 1109 -1 %
Max lifespan observed (days) 1212 1358
Number of mice at start 135 279
Animal censor events are denoted by + marks in the plot
All test sites combined – male
TM5441 effect on survival, males, test site = All
Log-rank test chisq = 0.1589 p = 0.6902
Wang-Allison test odds ratio = 1.5761 p = 0.1703
Quantiles TM5441 Control % difference
25% died before day: 666 638 +4 %
Median lifespan (days) 802 832 -4 %
75% died before day: 944 969 -3 %
90% died before day: 1079 1059 +2 %
Max lifespan observed (days) 1244 1272
Number of mice at start 144 273
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
TM5441 effect on survival, females, test site = TJL
Log-rank test chisq = 0.0077 p = 0.9301
Wang-Allison test odds ratio = 1.3778 p = 0.5725
Quantiles TM5441 Control % difference
25% died before day: 784 782 0 %
Median lifespan (days) 893 904 -1 %
75% died before day: 970 1010 -4 %
90% died before day: 1160 1099 +6 %
Max lifespan observed (days) 1212 1358
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
TM5441 effect on survival, males, test site = TJL
Log-rank test chisq = 0.4125 p = 0.5207
Wang-Allison test odds ratio = 1.2932 p = 0.7589
Quantiles TM5441 Control % difference
25% died before day: 644 572 +13 %
Median lifespan (days) 818 873 -6 %
75% died before day: 948 992 -4 %
90% died before day: 1086 1068 +2 %
Max lifespan observed (days) 1148 1272
Number of mice at start 48 93
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
TM5441 effect on survival, females, test site = UM
Log-rank test chisq = 1.8189 p = 0.1774
Wang-Allison test odds ratio = 0.1443 p = 0.0366
Quantiles TM5441 Control % difference
25% died before day: 750 748 0 %
Median lifespan (days) 870 884 -2 %
75% died before day: 992 1016 -2 %
90% died before day: 1040 1139 -9 %
Max lifespan observed (days) 1103 1210
Number of mice at start 43 91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
TM5441 effect on survival, males, test site = UM
Log-rank test chisq = 0.4105 p = 0.5217
Wang-Allison test odds ratio = 0.8143 p = 1.0
Quantiles TM5441 Control % difference
25% died before day: 690 756 -9 %
Median lifespan (days) 822 894 -8 %
75% died before day: 940 1009 -7 %
90% died before day: 1078 1084 -1 %
Max lifespan observed (days) 1244 1206
Number of mice at start 45 84
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
TM5441 effect on survival, females, test site = UT
Log-rank test chisq = 0.2677 p = 0.6049
Wang-Allison test odds ratio = 1.1808 p = 0.7697
Quantiles TM5441 Control % difference
25% died before day: 746 768 -3 %
Median lifespan (days) 906 882 +3 %
75% died before day: 1008 1046 -4 %
90% died before day: 1122 1109 +1 %
Max lifespan observed (days) 1187 1238
Number of mice at start 44 92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
TM5441 effect on survival, males, test site = UT
Log-rank test chisq = 3.263 p = 0.0709
Wang-Allison test odds ratio = 3.186 p = 0.0435
Quantiles TM5441 Control % difference
25% died before day: 578 570 +1 %
Median lifespan (days) 787 743 +6 %
75% died before day: 953 892 +7 %
90% died before day: 1066 977 +9 %
Max lifespan observed (days) 1132 1167
Number of mice at start 51 96
Animal censor events are denoted by + marks in the plot


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Statistical definitions