ITP survival analysis:   sulindac

Intervention:   sulindac     NSAID, acute or chronic inflammatory treatment
Trial code: Sul Dose: 5 ppm initiated at age: 5 mo Sex: both Cohort: C2017
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
Sul effect on survival, females, test site = All
Log-rank test chisq = 0.028 p = 0.8672
Wang-Allison test odds ratio = 1.5299 p = 0.2301
Quantiles Sul Control % difference
25% died before day: 764 767 0 %
Median lifespan (days) 852 868 -2 %
75% died before day: 963 958 +1 %
90% died before day: 1081 1060 +2 %
Max lifespan observed (days) 1178 1221
Number of mice at start 136 276
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Sul effect on survival, males, test site = All
Log-rank test chisq = 0.1582 p = 0.6909
Wang-Allison test odds ratio = 1.5791 p = 0.1779
Quantiles Sul Control % difference
25% died before day: 490 447 +10 %
Median lifespan (days) 698 718 -3 %
75% died before day: 892 919 -3 %
90% died before day: 1037 1029 +1 %
Max lifespan observed (days) 1302 1258
Number of mice at start 144 285
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
Sul effect on survival, females, test site = TJL
Log-rank test chisq = 0.8315 p = 0.3618
Wang-Allison test odds ratio = 2.5248 p = 0.0916
Quantiles Sul Control % difference
25% died before day: 796 760 +5 %
Median lifespan (days) 874 870 0 %
75% died before day: 987 968 +2 %
90% died before day: 1127 1068 +6 %
Max lifespan observed (days) 1178 1209
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
Sul effect on survival, males, test site = TJL
Log-rank test chisq = 0.3247 p = 0.5688
Wang-Allison test odds ratio = 1.996 p = 0.245
Quantiles Sul Control % difference
25% died before day: 490 488 0 %
Median lifespan (days) 710 748 -5 %
75% died before day: 936 949 -1 %
90% died before day: 1120 1079 +4 %
Max lifespan observed (days) 1191 1226
Number of mice at start 48 102
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
Sul effect on survival, females, test site = UM
Log-rank test chisq = 4.9168 p = 0.0266
Wang-Allison test odds ratio = 0.5278 p = 0.5483
Quantiles Sul Control % difference
25% died before day: 726 820 -11 %
Median lifespan (days) 841 902 -7 %
75% died before day: 940 1000 -6 %
90% died before day: 1072 1098 -2 %
Max lifespan observed (days) 1161 1221
Number of mice at start 44 90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
Sul effect on survival, males, test site = UM
Log-rank test chisq = 0.0071 p = 0.933
Wang-Allison test odds ratio = 1.5333 p = 0.5522
Quantiles Sul Control % difference
25% died before day: 452 468 -3 %
Median lifespan (days) 696 790 -12 %
75% died before day: 940 933 +1 %
90% died before day: 1067 1019 +5 %
Max lifespan observed (days) 1302 1233
Number of mice at start 45 88
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
Sul effect on survival, females, test site = UT
Log-rank test chisq = 1.7461 p = 0.1864
Wang-Allison test odds ratio = 2.2285 p = 0.227
Quantiles Sul Control % difference
25% died before day: 717 696 +3 %
Median lifespan (days) 850 824 +3 %
75% died before day: 980 937 +5 %
90% died before day: 1061 993 +7 %
Max lifespan observed (days) 1165 1198
Number of mice at start 44 90
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
Sul effect on survival, males, test site = UT
Log-rank test chisq = 0.0007 p = 0.9785
Wang-Allison test odds ratio = 1.2719 p = 0.7762
Quantiles Sul Control % difference
25% died before day: 528 400 +32 %
Median lifespan (days) 678 676 0 %
75% died before day: 822 825 0 %
90% died before day: 969 963 +1 %
Max lifespan observed (days) 1142 1258
Number of mice at start 51 95
Animal censor events are denoted by + marks in the plot


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Statistical definitions