ITP survival analysis: simvastatin
Intervention:
simvastatin
lipid-lowering drug
Trial code: Sim_lo
Dose: 12 ppm
initiated at age: 10 mo
Sex: both
Cohort: C2006
Trial code: Sim_hi
Dose: 120 ppm
initiated at age: 10 mo
Sex: both
Cohort: C2006
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
Sim_lo effect on survival,
females, test site = All
Log-rank test
chisq = 1.2608
p = 0.2615
Wang-Allison test
odds ratio = 1.328
p = 0.4851
Quantiles
Sim_lo
Control
% difference
25% died before day:
803
772
+4 %
Median lifespan (days)
916
882
+4 %
75% died before day:
1021
968
+5 %
90% died before day:
1088
1077
+1 %
Max lifespan observed (days)
1209
1261
Number of mice at start
142
237
Animal censor events are denoted by + marks in the plot
Sim_hi effect on survival,
females, test site = All
Log-rank test
chisq = 0.3526
p = 0.5526
Wang-Allison test
odds ratio = 1.5339
p = 0.2212
Quantiles
Sim_hi
Control
% difference
25% died before day:
748
772
-3 %
Median lifespan (days)
898
882
+2 %
75% died before day:
1015
968
+5 %
90% died before day:
1116
1077
+4 %
Max lifespan observed (days)
1357
1261
Number of mice at start
144
237
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
Sim_lo effect on survival,
males, test site = All
Log-rank test
chisq = 1.1571
p = 0.2821
Wang-Allison test
odds ratio = 1.6611
p = 0.1105
Quantiles
Sim_lo
Control
% difference
25% died before day:
673
650
+4 %
Median lifespan (days)
858
826
+4 %
75% died before day:
984
949
+4 %
90% died before day:
1081
1060
+2 %
Max lifespan observed (days)
1351
1268
Number of mice at start
166
309
Animal censor events are denoted by + marks in the plot
Sim_hi effect on survival,
males, test site = All
Log-rank test
chisq = 0.0
p = 0.9983
Wang-Allison test
odds ratio = 1.6904
p = 0.1085
Quantiles
Sim_hi
Control
% difference
25% died before day:
668
650
+3 %
Median lifespan (days)
789
826
-4 %
75% died before day:
940
949
-1 %
90% died before day:
1087
1060
+3 %
Max lifespan observed (days)
1385
1268
Number of mice at start
163
309
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
Sim_lo effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.7096
p = 0.3996
Wang-Allison test
odds ratio = 0.4603
p = 0.3554
Quantiles
Sim_lo
Control
% difference
25% died before day:
787
792
-1 %
Median lifespan (days)
892
888
0 %
75% died before day:
983
972
+1 %
90% died before day:
1032
1077
-4 %
Max lifespan observed (days)
1137
1261
Number of mice at start
46
68
Animal censor events are denoted by + marks in the plot
Sim_hi effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.1132
p = 0.7365
Wang-Allison test
odds ratio = 1.4711
p = 0.5495
Quantiles
Sim_hi
Control
% difference
25% died before day:
732
792
-8 %
Median lifespan (days)
872
888
-2 %
75% died before day:
1004
972
+3 %
90% died before day:
1141
1077
+6 %
Max lifespan observed (days)
1357
1261
Number of mice at start
48
68
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
Sim_lo effect on survival,
males, test site = TJL
Log-rank test
chisq = 2.5882
p = 0.1077
Wang-Allison test
odds ratio = 2.9777
p = 0.0555
Quantiles
Sim_lo
Control
% difference
25% died before day:
670
633
+6 %
Median lifespan (days)
810
800
+1 %
75% died before day:
988
916
+8 %
90% died before day:
1082
1007
+7 %
Max lifespan observed (days)
1351
1197
Number of mice at start
60
96
Animal censor events are denoted by + marks in the plot
Sim_hi effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.3833
p = 0.5359
Wang-Allison test
odds ratio = 2.9777
p = 0.0555
Quantiles
Sim_hi
Control
% difference
25% died before day:
602
633
-5 %
Median lifespan (days)
775
800
-3 %
75% died before day:
945
916
+3 %
90% died before day:
1107
1007
+10 %
Max lifespan observed (days)
1385
1197
Number of mice at start
60
96
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
Sim_lo effect on survival,
females, test site = UM
Log-rank test
chisq = 1.0676
p = 0.3015
Wang-Allison test
odds ratio = 2.6786
p = 0.0851
Quantiles
Sim_lo
Control
% difference
25% died before day:
765
788
-3 %
Median lifespan (days)
931
891
+4 %
75% died before day:
1042
990
+5 %
90% died before day:
1097
1069
+3 %
Max lifespan observed (days)
1200
1248
Number of mice at start
48
87
Animal censor events are denoted by + marks in the plot
Sim_hi effect on survival,
females, test site = UM
Log-rank test
chisq = 0.0679
p = 0.7945
Wang-Allison test
odds ratio = 1.941
p = 0.2504
Quantiles
Sim_hi
Control
% difference
25% died before day:
754
788
-4 %
Median lifespan (days)
894
891
0 %
75% died before day:
992
990
0 %
90% died before day:
1093
1069
+2 %
Max lifespan observed (days)
1185
1248
Number of mice at start
48
87
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
Sim_lo effect on survival,
males, test site = UM
Log-rank test
chisq = 0.1011
p = 0.7505
Wang-Allison test
odds ratio = 1.2366
p = 0.781
Quantiles
Sim_lo
Control
% difference
25% died before day:
736
701
+5 %
Median lifespan (days)
880
851
+3 %
75% died before day:
1018
974
+5 %
90% died before day:
1085
1077
+1 %
Max lifespan observed (days)
1202
1268
Number of mice at start
53
107
Animal censor events are denoted by + marks in the plot
Sim_hi effect on survival,
males, test site = UM
Log-rank test
chisq = 0.1367
p = 0.7116
Wang-Allison test
odds ratio = 2.1196
p = 0.1689
Quantiles
Sim_hi
Control
% difference
25% died before day:
698
701
0 %
Median lifespan (days)
880
851
+3 %
75% died before day:
964
974
-1 %
90% died before day:
1096
1077
+2 %
Max lifespan observed (days)
1267
1268
Number of mice at start
54
107
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
Sim_lo effect on survival,
females, test site = UT
Log-rank test
chisq = 2.6403
p = 0.1042
Wang-Allison test
odds ratio = 1.5253
p = 0.5487
Quantiles
Sim_lo
Control
% difference
25% died before day:
832
748
+11 %
Median lifespan (days)
934
843
+11 %
75% died before day:
1046
964
+9 %
90% died before day:
1118
1105
+1 %
Max lifespan observed (days)
1209
1192
Number of mice at start
48
82
Animal censor events are denoted by + marks in the plot
Sim_hi effect on survival,
females, test site = UT
Log-rank test
chisq = 1.1253
p = 0.2888
Wang-Allison test
odds ratio = 1.2108
p = 0.7623
Quantiles
Sim_hi
Control
% difference
25% died before day:
739
748
-1 %
Median lifespan (days)
919
843
+9 %
75% died before day:
1025
964
+6 %
90% died before day:
1119
1105
+1 %
Max lifespan observed (days)
1231
1192
Number of mice at start
48
82
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
Sim_lo effect on survival,
males, test site = UT
Log-rank test
chisq = 0.0076
p = 0.9304
Wang-Allison test
odds ratio = 1.2239
p = 0.7817
Quantiles
Sim_lo
Control
% difference
25% died before day:
631
586
+8 %
Median lifespan (days)
829
813
+2 %
75% died before day:
957
935
+2 %
90% died before day:
1061
1053
+1 %
Max lifespan observed (days)
1164
1212
Number of mice at start
53
106
Animal censor events are denoted by + marks in the plot
Sim_hi effect on survival,
males, test site = UT
Log-rank test
chisq = 1.1429
p = 0.285
Wang-Allison test
odds ratio = 0.6978
p = 0.7773
Quantiles
Sim_hi
Control
% difference
25% died before day:
619
586
+6 %
Median lifespan (days)
753
813
-7 %
75% died before day:
903
935
-3 %
90% died before day:
1031
1053
-2 %
Max lifespan observed (days)
1157
1212
Number of mice at start
49
106
Animal censor events are denoted by + marks in the plot
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Statistical definitions