ITP survival analysis: rapamycin
Intervention:
rapamycin
mTOR complex repressor, anti-aging
Trial code: Rapa_hi_start_stop
Dose: 42 ppm
initiated at age: 20 mo (stop at 23)
Sex: both
Cohort: C2015
Trial code: Rapa_hi_cycle
Dose: 42 ppm
initiated at age: 20 mo (but every other month)
Sex: both
Cohort: C2015
Trial code: Rapa_hi_continuous
Dose: 42 ppm
initiated at age: 20 mo
Sex: both
Cohort: C2015
This compound had a significant effect on survival: males p = 0.0243
This compound had a significant effect on survival: females = 0.0001; males p = 0.0019
This compound had a significant effect on survival: females p < 0.0001; males p = 0.0007
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
Rapa_hi_start_stop effect on survival,
females, test site = All
Log-rank test
chisq = 2.0984
p = 0.1475
Wang-Allison test
odds ratio = 1.608
p = 0.1664
Quantiles
Rapa_hi_start_stop
Control
% difference
25% died before day:
808
786
+3 %
Median lifespan (days)
940
904
+4 %
75% died before day:
1052
1016
+4 %
90% died before day:
1136
1095
+4 %
Max lifespan observed (days)
1274
1396
Number of mice at start
134
274
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival,
females, test site = All
Log-rank test
chisq = 15.7906
p < 0.0001
Wang-Allison test
odds ratio = 3.7741
p < 0.0001
Quantiles
Rapa_hi_cycle
Control
% difference
25% died before day:
825
786
+5 %
Median lifespan (days)
977
904
+8 %
75% died before day:
1117
1016
+10 %
90% died before day:
1203
1095
+10 %
Max lifespan observed (days)
1332
1396
Number of mice at start
133
274
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival,
females, test site = All
Log-rank test
chisq = 32.7164
p < 0.0001
Wang-Allison test
odds ratio = 9.7514
p < 0.0001
Quantiles
Rapa_hi_continuous
Control
% difference
25% died before day:
790
786
+1 %
Median lifespan (days)
1040
904
+15 %
75% died before day:
1174
1016
+16 %
90% died before day:
1231
1095
+12 %
Max lifespan observed (days)
1344
1396
Number of mice at start
136
274
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
Rapa_hi_start_stop effect on survival,
males, test site = All
Log-rank test
chisq = 5.0707
p = 0.0243
Wang-Allison test
odds ratio = 1.6173
p = 0.158
Quantiles
Rapa_hi_start_stop
Control
% difference
25% died before day:
608
581
+5 %
Median lifespan (days)
854
772
+11 %
75% died before day:
1020
918
+11 %
90% died before day:
1100
1049
+5 %
Max lifespan observed (days)
1264
1237
Number of mice at start
127
264
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival,
males, test site = All
Log-rank test
chisq = 9.6323
p = 0.0019
Wang-Allison test
odds ratio = 2.1132
p = 0.0251
Quantiles
Rapa_hi_cycle
Control
% difference
25% died before day:
584
581
+1 %
Median lifespan (days)
841
772
+9 %
75% died before day:
1056
918
+15 %
90% died before day:
1144
1049
+9 %
Max lifespan observed (days)
1348
1237
Number of mice at start
144
264
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival,
males, test site = All
Log-rank test
chisq = 11.6084
p = 0.0007
Wang-Allison test
odds ratio = 2.4057
p = 0.01
Quantiles
Rapa_hi_continuous
Control
% difference
25% died before day:
652
581
+12 %
Median lifespan (days)
856
772
+11 %
75% died before day:
1006
918
+10 %
90% died before day:
1148
1049
+9 %
Max lifespan observed (days)
1358
1237
Number of mice at start
146
264
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
Rapa_hi_start_stop effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.6533
p = 0.4189
Wang-Allison test
odds ratio = 1.1506
p = 0.7734
Quantiles
Rapa_hi_start_stop
Control
% difference
25% died before day:
879
785
+12 %
Median lifespan (days)
986
928
+6 %
75% died before day:
1067
1043
+2 %
90% died before day:
1169
1156
+1 %
Max lifespan observed (days)
1274
1396
Number of mice at start
46
95
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival,
females, test site = TJL
Log-rank test
chisq = 6.8447
p = 0.0089
Wang-Allison test
odds ratio = 3.0603
p = 0.0681
Quantiles
Rapa_hi_cycle
Control
% difference
25% died before day:
875
785
+11 %
Median lifespan (days)
1074
928
+16 %
75% died before day:
1138
1043
+9 %
90% died before day:
1226
1156
+6 %
Max lifespan observed (days)
1266
1396
Number of mice at start
46
95
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival,
females, test site = TJL
Log-rank test
chisq = 11.6026
p = 0.0007
Wang-Allison test
odds ratio = 6.6618
p = 0.0011
Quantiles
Rapa_hi_continuous
Control
% difference
25% died before day:
882
785
+12 %
Median lifespan (days)
1108
928
+19 %
75% died before day:
1202
1043
+15 %
90% died before day:
1275
1156
+10 %
Max lifespan observed (days)
1329
1396
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
Rapa_hi_start_stop effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.0666
p = 0.7963
Wang-Allison test
odds ratio = 0.8013
p = 1.0
Quantiles
Rapa_hi_start_stop
Control
% difference
25% died before day:
606
608
0 %
Median lifespan (days)
729
818
-11 %
75% died before day:
922
942
-2 %
90% died before day:
1029
1061
-3 %
Max lifespan observed (days)
1243
1237
Number of mice at start
45
92
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival,
males, test site = TJL
Log-rank test
chisq = 3.2273
p = 0.0724
Wang-Allison test
odds ratio = 2.2454
p = 0.1581
Quantiles
Rapa_hi_cycle
Control
% difference
25% died before day:
652
608
+7 %
Median lifespan (days)
826
818
+1 %
75% died before day:
1036
942
+10 %
90% died before day:
1173
1061
+11 %
Max lifespan observed (days)
1348
1237
Number of mice at start
51
92
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.8418
p = 0.3589
Wang-Allison test
odds ratio = 1.6642
p = 0.398
Quantiles
Rapa_hi_continuous
Control
% difference
25% died before day:
617
608
+1 %
Median lifespan (days)
817
818
0 %
75% died before day:
969
942
+3 %
90% died before day:
1138
1061
+7 %
Max lifespan observed (days)
1248
1237
Number of mice at start
51
92
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
Rapa_hi_start_stop effect on survival,
females, test site = UM
Log-rank test
chisq = 0.4948
p = 0.4818
Wang-Allison test
odds ratio = 2.2552
p = 0.2262
Quantiles
Rapa_hi_start_stop
Control
% difference
25% died before day:
780
791
-1 %
Median lifespan (days)
904
899
+1 %
75% died before day:
1036
992
+4 %
90% died before day:
1123
1079
+4 %
Max lifespan observed (days)
1249
1291
Number of mice at start
44
91
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival,
females, test site = UM
Log-rank test
chisq = 4.7597
p = 0.0291
Wang-Allison test
odds ratio = 4.3675
p = 0.0135
Quantiles
Rapa_hi_cycle
Control
% difference
25% died before day:
812
791
+3 %
Median lifespan (days)
937
899
+4 %
75% died before day:
1082
992
+9 %
90% died before day:
1184
1079
+10 %
Max lifespan observed (days)
1311
1291
Number of mice at start
44
91
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival,
females, test site = UM
Log-rank test
chisq = 5.1415
p = 0.0234
Wang-Allison test
odds ratio = 9.589
p = 0.0003
Quantiles
Rapa_hi_continuous
Control
% difference
25% died before day:
680
791
-14 %
Median lifespan (days)
920
899
+2 %
75% died before day:
1172
992
+18 %
90% died before day:
1189
1079
+10 %
Max lifespan observed (days)
1252
1291
Number of mice at start
44
91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
Rapa_hi_start_stop effect on survival,
males, test site = UM
Log-rank test
chisq = 2.195
p = 0.1385
Wang-Allison test
odds ratio = 2.6526
p = 0.1771
Quantiles
Rapa_hi_start_stop
Control
% difference
25% died before day:
596
601
-1 %
Median lifespan (days)
837
740
+13 %
75% died before day:
1025
905
+13 %
90% died before day:
1107
1027
+8 %
Max lifespan observed (days)
1162
1231
Number of mice at start
34
81
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival,
males, test site = UM
Log-rank test
chisq = 13.9215
p = 0.0002
Wang-Allison test
odds ratio = 4.3422
p = 0.023
Quantiles
Rapa_hi_cycle
Control
% difference
25% died before day:
745
601
+24 %
Median lifespan (days)
1044
740
+41 %
75% died before day:
1126
905
+24 %
90% died before day:
1156
1027
+13 %
Max lifespan observed (days)
1256
1231
Number of mice at start
45
81
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival,
males, test site = UM
Log-rank test
chisq = 2.439
p = 0.1183
Wang-Allison test
odds ratio = 3.0121
p = 0.0716
Quantiles
Rapa_hi_continuous
Control
% difference
25% died before day:
721
601
+20 %
Median lifespan (days)
828
740
+12 %
75% died before day:
982
905
+9 %
90% died before day:
1078
1027
+5 %
Max lifespan observed (days)
1162
1231
Number of mice at start
48
81
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
Rapa_hi_start_stop effect on survival,
females, test site = UT
Log-rank test
chisq = 0.9968
p = 0.3181
Wang-Allison test
odds ratio = 1.5732
p = 0.5496
Quantiles
Rapa_hi_start_stop
Control
% difference
25% died before day:
792
786
+1 %
Median lifespan (days)
940
892
+5 %
75% died before day:
1038
1014
+2 %
90% died before day:
1097
1078
+2 %
Max lifespan observed (days)
1229
1280
Number of mice at start
44
88
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival,
females, test site = UT
Log-rank test
chisq = 4.2871
p = 0.0384
Wang-Allison test
odds ratio = 3.9747
p = 0.025
Quantiles
Rapa_hi_cycle
Control
% difference
25% died before day:
753
786
-4 %
Median lifespan (days)
949
892
+6 %
75% died before day:
1105
1014
+9 %
90% died before day:
1162
1078
+8 %
Max lifespan observed (days)
1332
1280
Number of mice at start
43
88
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival,
females, test site = UT
Log-rank test
chisq = 17.899
p < 0.0001
Wang-Allison test
odds ratio = 15.7541
p < 0.0001
Quantiles
Rapa_hi_continuous
Control
% difference
25% died before day:
901
786
+15 %
Median lifespan (days)
1032
892
+16 %
75% died before day:
1149
1014
+13 %
90% died before day:
1192
1078
+11 %
Max lifespan observed (days)
1344
1280
Number of mice at start
44
88
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
Rapa_hi_start_stop effect on survival,
males, test site = UT
Log-rank test
chisq = 6.7747
p = 0.0092
Wang-Allison test
odds ratio = 2.0375
p = 0.2397
Quantiles
Rapa_hi_start_stop
Control
% difference
25% died before day:
682
500
+36 %
Median lifespan (days)
891
786
+13 %
75% died before day:
1038
888
+17 %
90% died before day:
1122
1025
+9 %
Max lifespan observed (days)
1264
1220
Number of mice at start
48
91
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival,
males, test site = UT
Log-rank test
chisq = 0.0077
p = 0.9299
Wang-Allison test
odds ratio = 1.059
p = 1.0
Quantiles
Rapa_hi_cycle
Control
% difference
25% died before day:
474
500
-5 %
Median lifespan (days)
744
786
-5 %
75% died before day:
981
888
+10 %
90% died before day:
1052
1025
+3 %
Max lifespan observed (days)
1127
1220
Number of mice at start
48
91
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival,
males, test site = UT
Log-rank test
chisq = 11.7865
p = 0.0006
Wang-Allison test
odds ratio = 2.8813
p = 0.074
Quantiles
Rapa_hi_continuous
Control
% difference
25% died before day:
611
500
+22 %
Median lifespan (days)
912
786
+16 %
75% died before day:
1066
888
+20 %
90% died before day:
1169
1025
+14 %
Max lifespan observed (days)
1358
1220
Number of mice at start
47
91
Animal censor events are denoted by + marks in the plot
See our
ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions