ITP survival analysis: rapamycin
Intervention:
rapamycin
mTOR complex repressor, anti-aging
Trial code: Rapa_lo
Dose: 4.7 ppm
initiated at age: 9 mo
Sex: both
Cohort: C2009
Trial code: Rapa_mid
Dose: 14 ppm
initiated at age: 9 mo
Sex: both
Cohort: C2009
Trial code: Rapa_hi
Dose: 42 ppm
initiated at age: 9 mo
Sex: both
Cohort: C2009
This compound had a significant effect on survival: 4.7 ppm females p < 0.0001; 14 ppm females p < 0.0001; 14 ppm males p = 0.0034; 42 ppm both sexes p < 0.0001
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
Rapa_lo effect on survival,
females, test site = All
Log-rank test
chisq = 48.8394
p < 0.0001
Wang-Allison test
odds ratio = 9.7884
p < 0.0001
Quantiles
Rapa_lo
Control
% difference
25% died before day:
856
778
+10 %
Median lifespan (days)
1035
881
+17 %
75% died before day:
1140
988
+15 %
90% died before day:
1218
1066
+14 %
Max lifespan observed (days)
1322
1229
Number of mice at start
115
242
Animal censor events are denoted by + marks in the plot
Rapa_mid effect on survival,
females, test site = All
Log-rank test
chisq = 89.5564
p < 0.0001
Wang-Allison test
odds ratio = 17.8911
p < 0.0001
Quantiles
Rapa_mid
Control
% difference
25% died before day:
933
778
+20 %
Median lifespan (days)
1079
881
+22 %
75% died before day:
1202
988
+22 %
90% died before day:
1287
1066
+21 %
Max lifespan observed (days)
1412
1229
Number of mice at start
116
242
Animal censor events are denoted by + marks in the plot
Rapa_hi effect on survival,
females, test site = All
Log-rank test
chisq = 142.653
p < 0.0001
Wang-Allison test
odds ratio = 17.8163
p < 0.0001
Quantiles
Rapa_hi
Control
% difference
25% died before day:
1050
778
+35 %
Median lifespan (days)
1130
881
+28 %
75% died before day:
1214
988
+23 %
90% died before day:
1278
1066
+20 %
Max lifespan observed (days)
1323
1229
Number of mice at start
120
242
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
Rapa_lo effect on survival,
males, test site = All
Log-rank test
chisq = 1.6494
p = 0.199
Wang-Allison test
odds ratio = 1.5593
p = 0.1805
Quantiles
Rapa_lo
Control
% difference
25% died before day:
565
616
-8 %
Median lifespan (days)
834
807
+3 %
75% died before day:
1013
973
+4 %
90% died before day:
1160
1094
+6 %
Max lifespan observed (days)
1464
1338
Number of mice at start
150
295
Animal censor events are denoted by + marks in the plot
Rapa_mid effect on survival,
males, test site = All
Log-rank test
chisq = 8.5846
p = 0.0034
Wang-Allison test
odds ratio = 2.3931
p = 0.0068
Quantiles
Rapa_mid
Control
% difference
25% died before day:
624
616
+1 %
Median lifespan (days)
884
807
+10 %
75% died before day:
1054
973
+8 %
90% died before day:
1178
1094
+8 %
Max lifespan observed (days)
1298
1338
Number of mice at start
142
295
Animal censor events are denoted by + marks in the plot
Rapa_hi effect on survival,
males, test site = All
Log-rank test
chisq = 23.9886
p < 0.0001
Wang-Allison test
odds ratio = 3.1087
p = 0.0009
Quantiles
Rapa_hi
Control
% difference
25% died before day:
683
616
+11 %
Median lifespan (days)
984
807
+22 %
75% died before day:
1110
973
+14 %
90% died before day:
1184
1094
+8 %
Max lifespan observed (days)
1348
1338
Number of mice at start
120
295
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
Rapa_lo effect on survival,
females, test site = TJL
Log-rank test
chisq = 21.0818
p < 0.0001
Wang-Allison test
odds ratio = 22.6911
p = 0.0003
Quantiles
Rapa_lo
Control
% difference
25% died before day:
897
768
+17 %
Median lifespan (days)
1050
894
+17 %
75% died before day:
1138
976
+17 %
90% died before day:
1219
1051
+16 %
Max lifespan observed (days)
1322
1197
Number of mice at start
28
60
Animal censor events are denoted by + marks in the plot
Rapa_mid effect on survival,
females, test site = TJL
Log-rank test
chisq = 16.2388
p < 0.0001
Wang-Allison test
odds ratio = 22.6911
p = 0.0003
Quantiles
Rapa_mid
Control
% difference
25% died before day:
901
768
+17 %
Median lifespan (days)
985
894
+10 %
75% died before day:
1183
976
+21 %
90% died before day:
1278
1051
+22 %
Max lifespan observed (days)
1412
1197
Number of mice at start
28
60
Animal censor events are denoted by + marks in the plot
Rapa_hi effect on survival,
females, test site = TJL
Log-rank test
chisq = 28.3864
p < 0.0001
Wang-Allison test
odds ratio = 22.2954
p = 0.0002
Quantiles
Rapa_hi
Control
% difference
25% died before day:
958
768
+25 %
Median lifespan (days)
1078
894
+21 %
75% died before day:
1193
976
+22 %
90% died before day:
1283
1051
+22 %
Max lifespan observed (days)
1291
1197
Number of mice at start
32
60
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
Rapa_lo effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.4194
p = 0.5172
Wang-Allison test
odds ratio = 1.2481
p = 0.7779
Quantiles
Rapa_lo
Control
% difference
25% died before day:
540
606
-11 %
Median lifespan (days)
761
807
-6 %
75% died before day:
943
941
0 %
90% died before day:
1106
1061
+4 %
Max lifespan observed (days)
1217
1338
Number of mice at start
54
101
Animal censor events are denoted by + marks in the plot
Rapa_mid effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.2635
p = 0.6077
Wang-Allison test
odds ratio = 1.5851
p = 0.4109
Quantiles
Rapa_mid
Control
% difference
25% died before day:
536
606
-12 %
Median lifespan (days)
718
807
-11 %
75% died before day:
1023
941
+9 %
90% died before day:
1156
1061
+9 %
Max lifespan observed (days)
1271
1338
Number of mice at start
52
101
Animal censor events are denoted by + marks in the plot
Rapa_hi effect on survival,
males, test site = TJL
Log-rank test
chisq = 6.8204
p = 0.009
Wang-Allison test
odds ratio = 3.7119
p = 0.0191
Quantiles
Rapa_hi
Control
% difference
25% died before day:
634
606
+5 %
Median lifespan (days)
835
807
+3 %
75% died before day:
1142
941
+21 %
90% died before day:
1272
1061
+20 %
Max lifespan observed (days)
1344
1338
Number of mice at start
47
101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
Rapa_lo effect on survival,
females, test site = UM
Log-rank test
chisq = 18.0495
p < 0.0001
Wang-Allison test
odds ratio = 9.7698
p = 0.0002
Quantiles
Rapa_lo
Control
% difference
25% died before day:
856
797
+7 %
Median lifespan (days)
1065
886
+20 %
75% died before day:
1160
1008
+15 %
90% died before day:
1217
1088
+12 %
Max lifespan observed (days)
1287
1229
Number of mice at start
43
90
Animal censor events are denoted by + marks in the plot
Rapa_mid effect on survival,
females, test site = UM
Log-rank test
chisq = 34.5487
p < 0.0001
Wang-Allison test
odds ratio = 36.3041
p < 0.0001
Quantiles
Rapa_mid
Control
% difference
25% died before day:
940
797
+18 %
Median lifespan (days)
1090
886
+23 %
75% died before day:
1222
1008
+21 %
90% died before day:
1285
1088
+18 %
Max lifespan observed (days)
1389
1229
Number of mice at start
44
90
Animal censor events are denoted by + marks in the plot
Rapa_hi effect on survival,
females, test site = UM
Log-rank test
chisq = 55.5326
p < 0.0001
Wang-Allison test
odds ratio = 9.4804
p = 0.0003
Quantiles
Rapa_hi
Control
% difference
25% died before day:
1072
797
+35 %
Median lifespan (days)
1160
886
+31 %
75% died before day:
1198
1008
+19 %
90% died before day:
1274
1088
+17 %
Max lifespan observed (days)
1323
1229
Number of mice at start
44
90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
Rapa_lo effect on survival,
males, test site = UM
Log-rank test
chisq = 5.1703
p = 0.023
Wang-Allison test
odds ratio = 2.4966
p = 0.1454
Quantiles
Rapa_lo
Control
% difference
25% died before day:
822
742
+11 %
Median lifespan (days)
990
925
+7 %
75% died before day:
1146
1077
+6 %
90% died before day:
1298
1151
+13 %
Max lifespan observed (days)
1464
1325
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
Rapa_mid effect on survival,
males, test site = UM
Log-rank test
chisq = 1.1518
p = 0.2832
Wang-Allison test
odds ratio = 1.8041
p = 0.3606
Quantiles
Rapa_mid
Control
% difference
25% died before day:
826
742
+11 %
Median lifespan (days)
1004
925
+9 %
75% died before day:
1100
1077
+2 %
90% died before day:
1203
1151
+5 %
Max lifespan observed (days)
1269
1325
Number of mice at start
42
95
Animal censor events are denoted by + marks in the plot
Rapa_hi effect on survival,
males, test site = UM
Log-rank test
chisq = 8.6236
p = 0.0033
Wang-Allison test
odds ratio = 1.8033
p = 0.3344
Quantiles
Rapa_hi
Control
% difference
25% died before day:
954
742
+29 %
Median lifespan (days)
1075
925
+16 %
75% died before day:
1142
1077
+6 %
90% died before day:
1270
1151
+10 %
Max lifespan observed (days)
1348
1325
Number of mice at start
36
95
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
Rapa_lo effect on survival,
females, test site = UT
Log-rank test
chisq = 12.0323
p = 0.0005
Wang-Allison test
odds ratio = 6.3687
p = 0.0019
Quantiles
Rapa_lo
Control
% difference
25% died before day:
850
750
+13 %
Median lifespan (days)
950
866
+10 %
75% died before day:
1112
994
+12 %
90% died before day:
1218
1062
+15 %
Max lifespan observed (days)
1287
1213
Number of mice at start
44
92
Animal censor events are denoted by + marks in the plot
Rapa_mid effect on survival,
females, test site = UT
Log-rank test
chisq = 39.4028
p < 0.0001
Wang-Allison test
odds ratio = 9.6976
p = 0.0002
Quantiles
Rapa_mid
Control
% difference
25% died before day:
1010
750
+35 %
Median lifespan (days)
1095
866
+26 %
75% died before day:
1196
994
+20 %
90% died before day:
1314
1062
+24 %
Max lifespan observed (days)
1379
1213
Number of mice at start
44
92
Animal censor events are denoted by + marks in the plot
Rapa_hi effect on survival,
females, test site = UT
Log-rank test
chisq = 59.5087
p < 0.0001
Wang-Allison test
odds ratio = 37.1192
p < 0.0001
Quantiles
Rapa_hi
Control
% difference
25% died before day:
1072
750
+43 %
Median lifespan (days)
1137
866
+31 %
75% died before day:
1225
994
+23 %
90% died before day:
1259
1062
+19 %
Max lifespan observed (days)
1321
1213
Number of mice at start
44
92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
Rapa_lo effect on survival,
males, test site = UT
Log-rank test
chisq = 0.3569
p = 0.5503
Wang-Allison test
odds ratio = 1.1759
p = 0.7708
Quantiles
Rapa_lo
Control
% difference
25% died before day:
466
497
-6 %
Median lifespan (days)
665
704
-6 %
75% died before day:
926
903
+3 %
90% died before day:
1025
1013
+1 %
Max lifespan observed (days)
1261
1133
Number of mice at start
48
99
Animal censor events are denoted by + marks in the plot
Rapa_mid effect on survival,
males, test site = UT
Log-rank test
chisq = 12.2962
p = 0.0005
Wang-Allison test
odds ratio = 4.8862
p = 0.0066
Quantiles
Rapa_mid
Control
% difference
25% died before day:
600
497
+21 %
Median lifespan (days)
854
704
+21 %
75% died before day:
1038
903
+15 %
90% died before day:
1178
1013
+16 %
Max lifespan observed (days)
1298
1133
Number of mice at start
48
99
Animal censor events are denoted by + marks in the plot
Rapa_hi effect on survival,
males, test site = UT
Log-rank test
chisq = 8.679
p = 0.0032
Wang-Allison test
odds ratio = 4.2206
p = 0.0216
Quantiles
Rapa_hi
Control
% difference
25% died before day:
650
497
+31 %
Median lifespan (days)
893
704
+27 %
75% died before day:
1046
903
+16 %
90% died before day:
1098
1013
+8 %
Max lifespan observed (days)
1126
1133
Number of mice at start
37
99
Animal censor events are denoted by + marks in the plot
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Statistical definitions