ITP survival analysis: rapamycin
This compound had a significant effect on survival: both sexes p < 0.0001
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
Rapa effect on survival,
females, test site = All
Log-rank test
chisq = 41.321
p < 0.0001
Wang-Allison test
odds ratio = 5.4126
p < 0.0001
Quantiles
Rapa
Control
% difference
25% died before day:
831
756
+10 %
Median lifespan (days)
1005
886
+13 %
75% died before day:
1125
983
+14 %
90% died before day:
1249
1094
+14 %
Max lifespan observed (days)
1360
1281
Number of mice at start
143
289
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
Rapa effect on survival,
males, test site = All
Log-rank test
chisq = 34.3093
p < 0.0001
Wang-Allison test
odds ratio = 4.1244
p < 0.0001
Quantiles
Rapa
Control
% difference
25% died before day:
730
597
+22 %
Median lifespan (days)
949
794
+20 %
75% died before day:
1092
964
+13 %
90% died before day:
1176
1078
+9 %
Max lifespan observed (days)
1254
1303
Number of mice at start
168
357
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
Rapa effect on survival,
females, test site = TJL
Log-rank test
chisq = 19.6086
p < 0.0001
Wang-Allison test
odds ratio = 6.8437
p = 0.0009
Quantiles
Rapa
Control
% difference
25% died before day:
823
748
+10 %
Median lifespan (days)
1011
881
+15 %
75% died before day:
1163
952
+22 %
90% died before day:
1282
1100
+17 %
Max lifespan observed (days)
1360
1229
Number of mice at start
47
95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
Rapa effect on survival,
males, test site = TJL
Log-rank test
chisq = 4.4511
p = 0.0349
Wang-Allison test
odds ratio = 3.4994
p = 0.0159
Quantiles
Rapa
Control
% difference
25% died before day:
639
575
+11 %
Median lifespan (days)
815
802
+2 %
75% died before day:
1044
937
+11 %
90% died before day:
1142
1035
+10 %
Max lifespan observed (days)
1196
1220
Number of mice at start
57
126
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
Rapa effect on survival,
females, test site = UM
Log-rank test
chisq = 22.1401
p < 0.0001
Wang-Allison test
odds ratio = 16.8954
p < 0.0001
Quantiles
Rapa
Control
% difference
25% died before day:
856
731
+17 %
Median lifespan (days)
1030
878
+17 %
75% died before day:
1170
1016
+15 %
90% died before day:
1252
1094
+14 %
Max lifespan observed (days)
1274
1248
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
Rapa effect on survival,
males, test site = UM
Log-rank test
chisq = 6.2559
p = 0.0124
Wang-Allison test
odds ratio = 2.4372
p = 0.0948
Quantiles
Rapa
Control
% difference
25% died before day:
852
676
+26 %
Median lifespan (days)
1053
895
+18 %
75% died before day:
1114
1042
+7 %
90% died before day:
1186
1141
+4 %
Max lifespan observed (days)
1254
1303
Number of mice at start
51
112
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
Rapa effect on survival,
females, test site = UT
Log-rank test
chisq = 4.4344
p = 0.0352
Wang-Allison test
odds ratio = 1.9327
p = 0.2513
Quantiles
Rapa
Control
% difference
25% died before day:
816
776
+5 %
Median lifespan (days)
958
896
+7 %
75% died before day:
1069
984
+9 %
90% died before day:
1179
1089
+8 %
Max lifespan observed (days)
1272
1281
Number of mice at start
48
99
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
Rapa effect on survival,
males, test site = UT
Log-rank test
chisq = 30.7045
p < 0.0001
Wang-Allison test
odds ratio = 8.6306
p < 0.0001
Quantiles
Rapa
Control
% difference
25% died before day:
751
527
+43 %
Median lifespan (days)
969
722
+34 %
75% died before day:
1094
865
+26 %
90% died before day:
1186
1020
+16 %
Max lifespan observed (days)
1235
1176
Number of mice at start
60
119
Animal censor events are denoted by + marks in the plot
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ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions