ITP survival analysis: Protandim
Intervention:
Protandim
dietary supplement, anti-aging
Trial code: Prot
Dose: 600 ppm then 1200 ppm
initiated at age: 10 mo then 17 mo
Sex: both
Cohort: C2011
This compound had a significant effect on survival: males p = 0.0095
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
Prot effect on survival,
females, test site = All
Log-rank test
chisq = 1.1145
p = 0.2911
Wang-Allison test
odds ratio = 1.6466
p = 0.1633
Quantiles
Prot
Control
% difference
25% died before day:
778
771
+1 %
Median lifespan (days)
886
873
+1 %
75% died before day:
1013
985
+3 %
90% died before day:
1122
1089
+3 %
Max lifespan observed (days)
1291
1456
Number of mice at start
134
281
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
Prot effect on survival,
males, test site = All
Log-rank test
chisq = 6.7287
p = 0.0095
Wang-Allison test
odds ratio = 1.6843
p = 0.103
Quantiles
Prot
Control
% difference
25% died before day:
650
595
+9 %
Median lifespan (days)
853
783
+9 %
75% died before day:
998
921
+8 %
90% died before day:
1106
1057
+5 %
Max lifespan observed (days)
1323
1258
Number of mice at start
155
294
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
Prot effect on survival,
females, test site = TJL
Log-rank test
chisq = 1.5054
p = 0.2198
Wang-Allison test
odds ratio = 1.8482
p = 0.2625
Quantiles
Prot
Control
% difference
25% died before day:
746
788
-5 %
Median lifespan (days)
890
892
0 %
75% died before day:
1050
1015
+3 %
90% died before day:
1246
1106
+13 %
Max lifespan observed (days)
1291
1267
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
Prot effect on survival,
males, test site = TJL
Log-rank test
chisq = 2.5085
p = 0.1132
Wang-Allison test
odds ratio = 2.012
p = 0.2667
Quantiles
Prot
Control
% difference
25% died before day:
609
587
+4 %
Median lifespan (days)
767
763
+1 %
75% died before day:
1005
886
+13 %
90% died before day:
1189
1057
+12 %
Max lifespan observed (days)
1323
1258
Number of mice at start
54
101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
Prot effect on survival,
females, test site = UM
Log-rank test
chisq = 0.0177
p = 0.8941
Wang-Allison test
odds ratio = 1.7556
p = 0.3657
Quantiles
Prot
Control
% difference
25% died before day:
781
750
+4 %
Median lifespan (days)
872
872
0 %
75% died before day:
981
979
0 %
90% died before day:
1116
1081
+3 %
Max lifespan observed (days)
1171
1456
Number of mice at start
43
95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
Prot effect on survival,
males, test site = UM
Log-rank test
chisq = 0.5995
p = 0.4388
Wang-Allison test
odds ratio = 0.9338
p = 1.0
Quantiles
Prot
Control
% difference
25% died before day:
803
712
+13 %
Median lifespan (days)
918
860
+7 %
75% died before day:
1014
983
+3 %
90% died before day:
1123
1121
0 %
Max lifespan observed (days)
1212
1251
Number of mice at start
50
94
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
Prot effect on survival,
females, test site = UT
Log-rank test
chisq = 0.4917
p = 0.4832
Wang-Allison test
odds ratio = 1.3293
p = 0.7565
Quantiles
Prot
Control
% difference
25% died before day:
742
754
-2 %
Median lifespan (days)
926
857
+8 %
75% died before day:
1004
977
+3 %
90% died before day:
1099
1089
+1 %
Max lifespan observed (days)
1185
1301
Number of mice at start
43
91
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
Prot effect on survival,
males, test site = UT
Log-rank test
chisq = 4.4797
p = 0.0343
Wang-Allison test
odds ratio = 2.4293
p = 0.1481
Quantiles
Prot
Control
% difference
25% died before day:
481
542
-11 %
Median lifespan (days)
816
715
+14 %
75% died before day:
979
857
+14 %
90% died before day:
1077
1013
+6 %
Max lifespan observed (days)
1217
1186
Number of mice at start
51
99
Animal censor events are denoted by + marks in the plot
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National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions