ITP survival analysis:   nicotinamide riboside

Intervention:   nicotinamide riboside     precursor to nicotinamide adenine dinucleotide
Trial code: NR Dose: 1000 ppm initiated at age: 8 mo Sex: both Cohort: C2016
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
NR effect on survival, females, test site = All
Log-rank test chisq = 0.2573 p = 0.612
Wang-Allison test odds ratio = 1.0538 p = 0.8646
Quantiles NR Control % difference
25% died before day: 761 790 -4 %
Median lifespan (days) 856 875 -2 %
75% died before day: 986 975 +1 %
90% died before day: 1087 1055 +3 %
Max lifespan observed (days) 1281 1339
Number of mice at start 134 303
Animal censor events are denoted by + marks in the plot
All test sites combined – male
NR effect on survival, males, test site = All
Log-rank test chisq = 1.3109 p = 0.2522
Wang-Allison test odds ratio = 1.0178 p = 1.0
Quantiles NR Control % difference
25% died before day: 600 608 -1 %
Median lifespan (days) 760 782 -3 %
75% died before day: 897 935 -4 %
90% died before day: 1059 1055 0 %
Max lifespan observed (days) 1207 1264
Number of mice at start 145 275
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
NR effect on survival, females, test site = TJL
Log-rank test chisq = 4.1568 p = 0.0415
Wang-Allison test odds ratio = 1.8939 p = 0.2559
Quantiles NR Control % difference
25% died before day: 810 816 -1 %
Median lifespan (days) 968 883 +10 %
75% died before day: 1036 971 +7 %
90% died before day: 1174 1057 +11 %
Max lifespan observed (days) 1281 1230
Number of mice at start 47 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
NR effect on survival, males, test site = TJL
Log-rank test chisq = 0.0557 p = 0.8135
Wang-Allison test odds ratio = 1.2301 p = 0.7785
Quantiles NR Control % difference
25% died before day: 590 608 -3 %
Median lifespan (days) 748 749 0 %
75% died before day: 868 891 -3 %
90% died before day: 1008 1005 0 %
Max lifespan observed (days) 1191 1262
Number of mice at start 52 94
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
NR effect on survival, females, test site = UM
Log-rank test chisq = 5.2648 p = 0.0218
Wang-Allison test odds ratio = 0.5545 p = 0.5473
Quantiles NR Control % difference
25% died before day: 735 788 -7 %
Median lifespan (days) 799 858 -7 %
75% died before day: 872 961 -9 %
90% died before day: 1008 1034 -3 %
Max lifespan observed (days) 1124 1189
Number of mice at start 43 92
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
NR effect on survival, males, test site = UM
Log-rank test chisq = 0.3159 p = 0.5741
Wang-Allison test odds ratio = 1.7769 p = 0.3609
Quantiles NR Control % difference
25% died before day: 697 534 +31 %
Median lifespan (days) 830 814 +2 %
75% died before day: 947 996 -5 %
90% died before day: 1096 1071 +2 %
Max lifespan observed (days) 1207 1258
Number of mice at start 42 82
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
NR effect on survival, females, test site = UT
Log-rank test chisq = 0.931 p = 0.3346
Wang-Allison test odds ratio = 0.9367 p = 1.0
Quantiles NR Control % difference
25% died before day: 768 774 -1 %
Median lifespan (days) 856 882 -3 %
75% died before day: 940 984 -4 %
90% died before day: 1023 1058 -3 %
Max lifespan observed (days) 1168 1339
Number of mice at start 44 116
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
NR effect on survival, males, test site = UT
Log-rank test chisq = 5.515 p = 0.0189
Wang-Allison test odds ratio = 0.4552 p = 0.2666
Quantiles NR Control % difference
25% died before day: 561 640 -12 %
Median lifespan (days) 712 799 -11 %
75% died before day: 868 936 -7 %
90% died before day: 953 1064 -10 %
Max lifespan observed (days) 1078 1264
Number of mice at start 51 99
Animal censor events are denoted by + marks in the plot


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Statistical definitions