ITP survival analysis: nitroflurbiprofen
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
NFP effect on survival,
females, test site = All
Log-rank test
chisq = 0.5038
p = 0.4778
Wang-Allison test
odds ratio = 0.8786
p = 0.8631
Quantiles
NFP
Control
% difference
25% died before day:
769
739
+4 %
Median lifespan (days)
884
888
0 %
75% died before day:
970
988
-2 %
90% died before day:
1052
1072
-2 %
Max lifespan observed (days)
1217
1212
Number of mice at start
136
271
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
NFP effect on survival,
males, test site = All
Log-rank test
chisq = 0.7045
p = 0.4013
Wang-Allison test
odds ratio = 0.9279
p = 0.8792
Quantiles
NFP
Control
% difference
25% died before day:
642
612
+5 %
Median lifespan (days)
812
784
+4 %
75% died before day:
951
912
+4 %
90% died before day:
1025
1048
-2 %
Max lifespan observed (days)
1203
1305
Number of mice at start
172
350
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
NFP effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.0279
p = 0.8673
Wang-Allison test
odds ratio = 1.0718
p = 1.0
Quantiles
NFP
Control
% difference
25% died before day:
776
738
+5 %
Median lifespan (days)
898
858
+5 %
75% died before day:
990
969
+2 %
90% died before day:
1077
1050
+3 %
Max lifespan observed (days)
1144
1212
Number of mice at start
48
93
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
NFP effect on survival,
males, test site = TJL
Log-rank test
chisq = 3.8581
p = 0.0495
Wang-Allison test
odds ratio = 2.021
p = 0.1944
Quantiles
NFP
Control
% difference
25% died before day:
632
553
+14 %
Median lifespan (days)
792
757
+5 %
75% died before day:
962
875
+10 %
90% died before day:
1068
967
+10 %
Max lifespan observed (days)
1203
1216
Number of mice at start
60
125
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
NFP effect on survival,
females, test site = UM
Log-rank test
chisq = 0.3859
p = 0.5345
Wang-Allison test
odds ratio = 0.5862
p = 0.5426
Quantiles
NFP
Control
% difference
25% died before day:
784
772
+2 %
Median lifespan (days)
894
916
-2 %
75% died before day:
955
1005
-5 %
90% died before day:
1043
1111
-6 %
Max lifespan observed (days)
1210
1210
Number of mice at start
40
82
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
NFP effect on survival,
males, test site = UM
Log-rank test
chisq = 2.2469
p = 0.1339
Wang-Allison test
odds ratio = 0.367
p = 0.1777
Quantiles
NFP
Control
% difference
25% died before day:
728
727
0 %
Median lifespan (days)
831
864
-4 %
75% died before day:
969
995
-3 %
90% died before day:
1028
1121
-8 %
Max lifespan observed (days)
1190
1305
Number of mice at start
57
106
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
NFP effect on survival,
females, test site = UT
Log-rank test
chisq = 0.6581
p = 0.4172
Wang-Allison test
odds ratio = 1.0
p = 1.0
Quantiles
NFP
Control
% difference
25% died before day:
690
744
-7 %
Median lifespan (days)
834
880
-5 %
75% died before day:
960
994
-3 %
90% died before day:
1086
1076
+1 %
Max lifespan observed (days)
1217
1188
Number of mice at start
48
96
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
NFP effect on survival,
males, test site = UT
Log-rank test
chisq = 0.5795
p = 0.4465
Wang-Allison test
odds ratio = 0.8163
p = 0.7952
Quantiles
NFP
Control
% difference
25% died before day:
559
592
-6 %
Median lifespan (days)
764
739
+3 %
75% died before day:
907
877
+3 %
90% died before day:
981
988
-1 %
Max lifespan observed (days)
1145
1132
Number of mice at start
55
119
Animal censor events are denoted by + marks in the plot
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ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions