ITP survival analysis: nordihydroguaiaretic acid
Intervention:
nordihydroguaiaretic acid
antioxidant, anti-aging
Trial code: NDGA_lo
Dose: 800 ppm
initiated at age: 6 mo
Sex: m
Cohort: C2010
Trial code: NDGA_mid
Dose: 2500 ppm
initiated at age: 6 mo
Sex: m
Cohort: C2010
Trial code: NDGA_hi
Dose: 5000 ppm
initiated at age: 6 mo
Sex: both
Cohort: C2010
This compound had a significant effect on survival: 800 ppm males p = 0.0228; 2500 ppm males p = 0.0147; 5000 ppm males p = 0.0028
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
NDGA_hi effect on survival,
females, test site = All
Log-rank test
chisq = 0.6604
p = 0.4164
Wang-Allison test
odds ratio = 0.7824
p = 0.5938
Quantiles
NDGA_hi
Control
% difference
25% died before day:
750
786
-5 %
Median lifespan (days)
862
896
-4 %
75% died before day:
998
1034
-3 %
90% died before day:
1106
1116
-1 %
Max lifespan observed (days)
1371
1298
Number of mice at start
125
264
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
NDGA_lo effect on survival,
males, test site = All
Log-rank test
chisq = 5.1834
p = 0.0228
Wang-Allison test
odds ratio = 0.9231
p = 0.8639
Quantiles
NDGA_lo
Control
% difference
25% died before day:
650
586
+11 %
Median lifespan (days)
846
777
+9 %
75% died before day:
1018
953
+7 %
90% died before day:
1103
1090
+1 %
Max lifespan observed (days)
1316
1309
Number of mice at start
132
274
Animal censor events are denoted by + marks in the plot
NDGA_mid effect on survival,
males, test site = All
Log-rank test
chisq = 5.9527
p = 0.0147
Wang-Allison test
odds ratio = 0.8814
p = 0.8637
Quantiles
NDGA_mid
Control
% difference
25% died before day:
727
586
+24 %
Median lifespan (days)
868
777
+12 %
75% died before day:
1000
953
+5 %
90% died before day:
1095
1090
0 %
Max lifespan observed (days)
1373
1309
Number of mice at start
133
274
Animal censor events are denoted by + marks in the plot
NDGA_hi effect on survival,
males, test site = All
Log-rank test
chisq = 8.9645
p = 0.0028
Wang-Allison test
odds ratio = 1.7547
p = 0.0874
Quantiles
NDGA_hi
Control
% difference
25% died before day:
719
586
+23 %
Median lifespan (days)
834
777
+7 %
75% died before day:
987
953
+4 %
90% died before day:
1110
1090
+2 %
Max lifespan observed (days)
1282
1309
Number of mice at start
137
274
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
NDGA_hi effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.0203
p = 0.8866
Wang-Allison test
odds ratio = 1.1808
p = 0.7697
Quantiles
NDGA_hi
Control
% difference
25% died before day:
726
774
-6 %
Median lifespan (days)
859
864
-1 %
75% died before day:
990
993
0 %
90% died before day:
1106
1102
0 %
Max lifespan observed (days)
1278
1222
Number of mice at start
44
92
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
NDGA_lo effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.8237
p = 0.3641
Wang-Allison test
odds ratio = 0.3955
p = 0.342
Quantiles
NDGA_lo
Control
% difference
25% died before day:
599
498
+20 %
Median lifespan (days)
731
683
+7 %
75% died before day:
904
819
+10 %
90% died before day:
999
1067
-6 %
Max lifespan observed (days)
1057
1309
Number of mice at start
39
91
Animal censor events are denoted by + marks in the plot
NDGA_mid effect on survival,
males, test site = TJL
Log-rank test
chisq = 3.0602
p = 0.0802
Wang-Allison test
odds ratio = 0.5617
p = 0.5471
Quantiles
NDGA_mid
Control
% difference
25% died before day:
616
498
+24 %
Median lifespan (days)
794
683
+16 %
75% died before day:
881
819
+8 %
90% died before day:
1034
1067
-3 %
Max lifespan observed (days)
1181
1309
Number of mice at start
42
91
Animal censor events are denoted by + marks in the plot
NDGA_hi effect on survival,
males, test site = TJL
Log-rank test
chisq = 3.2358
p = 0.072
Wang-Allison test
odds ratio = 0.5217
p = 0.3865
Quantiles
NDGA_hi
Control
% difference
25% died before day:
672
498
+35 %
Median lifespan (days)
812
683
+19 %
75% died before day:
918
819
+12 %
90% died before day:
1020
1067
-4 %
Max lifespan observed (days)
1110
1309
Number of mice at start
45
91
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
NDGA_hi effect on survival,
females, test site = UM
Log-rank test
chisq = 0.2661
p = 0.6059
Wang-Allison test
odds ratio = 0.9493
p = 1.0
Quantiles
NDGA_hi
Control
% difference
25% died before day:
814
811
0 %
Median lifespan (days)
947
930
+2 %
75% died before day:
1043
1064
-2 %
90% died before day:
1122
1132
-1 %
Max lifespan observed (days)
1371
1255
Number of mice at start
41
88
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
NDGA_lo effect on survival,
males, test site = UM
Log-rank test
chisq = 1.2431
p = 0.2649
Wang-Allison test
odds ratio = 1.0699
p = 1.0
Quantiles
NDGA_lo
Control
% difference
25% died before day:
845
794
+6 %
Median lifespan (days)
992
926
+7 %
75% died before day:
1083
1050
+3 %
90% died before day:
1164
1146
+2 %
Max lifespan observed (days)
1316
1294
Number of mice at start
46
88
Animal censor events are denoted by + marks in the plot
NDGA_mid effect on survival,
males, test site = UM
Log-rank test
chisq = 0.1389
p = 0.7094
Wang-Allison test
odds ratio = 0.7814
p = 0.7734
Quantiles
NDGA_mid
Control
% difference
25% died before day:
824
794
+4 %
Median lifespan (days)
944
926
+2 %
75% died before day:
1042
1050
-1 %
90% died before day:
1105
1146
-4 %
Max lifespan observed (days)
1373
1294
Number of mice at start
44
88
Animal censor events are denoted by + marks in the plot
NDGA_hi effect on survival,
males, test site = UM
Log-rank test
chisq = 0.027
p = 0.8694
Wang-Allison test
odds ratio = 3.789
p = 0.0348
Quantiles
NDGA_hi
Control
% difference
25% died before day:
740
794
-7 %
Median lifespan (days)
864
926
-7 %
75% died before day:
1040
1050
-1 %
90% died before day:
1210
1146
+6 %
Max lifespan observed (days)
1282
1294
Number of mice at start
48
88
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
NDGA_hi effect on survival,
females, test site = UT
Log-rank test
chisq = 3.7399
p = 0.0531
Wang-Allison test
odds ratio = 0.3518
p = 0.2201
Quantiles
NDGA_hi
Control
% difference
25% died before day:
706
773
-9 %
Median lifespan (days)
814
906
-10 %
75% died before day:
964
1021
-6 %
90% died before day:
1004
1100
-9 %
Max lifespan observed (days)
1213
1298
Number of mice at start
40
84
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
NDGA_lo effect on survival,
males, test site = UT
Log-rank test
chisq = 3.5709
p = 0.0588
Wang-Allison test
odds ratio = 1.395
p = 0.5699
Quantiles
NDGA_lo
Control
% difference
25% died before day:
581
527
+10 %
Median lifespan (days)
771
732
+5 %
75% died before day:
958
889
+8 %
90% died before day:
1145
1041
+10 %
Max lifespan observed (days)
1247
1155
Number of mice at start
47
95
Animal censor events are denoted by + marks in the plot
NDGA_mid effect on survival,
males, test site = UT
Log-rank test
chisq = 4.1927
p = 0.0406
Wang-Allison test
odds ratio = 1.395
p = 0.5699
Quantiles
NDGA_mid
Control
% difference
25% died before day:
661
527
+25 %
Median lifespan (days)
816
732
+11 %
75% died before day:
957
889
+8 %
90% died before day:
1102
1041
+6 %
Max lifespan observed (days)
1156
1155
Number of mice at start
47
95
Animal censor events are denoted by + marks in the plot
NDGA_hi effect on survival,
males, test site = UT
Log-rank test
chisq = 9.994
p = 0.0016
Wang-Allison test
odds ratio = 2.362
p = 0.1368
Quantiles
NDGA_hi
Control
% difference
25% died before day:
732
527
+39 %
Median lifespan (days)
840
732
+15 %
75% died before day:
993
889
+12 %
90% died before day:
1094
1041
+5 %
Max lifespan observed (days)
1220
1155
Number of mice at start
44
95
Animal censor events are denoted by + marks in the plot
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Statistical definitions