ITP survival analysis: nordihydroguaiaretic acid
Intervention:
nordihydroguaiaretic acid
antioxidant, anti-aging
Trial code: NDGA
Dose: 2500 ppm
initiated at age: 9 mo
Sex: both
Cohort: C2004
This compound had a significant effect on survival: males p = 0.0006
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
NDGA effect on survival,
females, test site = All
Log-rank test
chisq = 0.1816
p = 0.67
Wang-Allison test
odds ratio = 1.1018
p = 0.8634
Quantiles
NDGA
Control
% difference
25% died before day:
764
739
+3 %
Median lifespan (days)
895
888
+1 %
75% died before day:
983
988
-1 %
90% died before day:
1094
1072
+2 %
Max lifespan observed (days)
1249
1212
Number of mice at start
139
271
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
NDGA effect on survival,
males, test site = All
Log-rank test
chisq = 11.8982
p = 0.0006
Wang-Allison test
odds ratio = 1.5492
p = 0.1629
Quantiles
NDGA
Control
% difference
25% died before day:
713
612
+17 %
Median lifespan (days)
881
784
+12 %
75% died before day:
989
912
+8 %
90% died before day:
1098
1048
+5 %
Max lifespan observed (days)
1267
1305
Number of mice at start
169
350
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
NDGA effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.008
p = 0.9287
Wang-Allison test
odds ratio = 1.5498
p = 0.552
Quantiles
NDGA
Control
% difference
25% died before day:
748
738
+1 %
Median lifespan (days)
892
858
+4 %
75% died before day:
967
969
0 %
90% died before day:
1073
1050
+2 %
Max lifespan observed (days)
1169
1212
Number of mice at start
48
93
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
NDGA effect on survival,
males, test site = TJL
Log-rank test
chisq = 2.8903
p = 0.0891
Wang-Allison test
odds ratio = 2.1463
p = 0.1227
Quantiles
NDGA
Control
% difference
25% died before day:
664
553
+20 %
Median lifespan (days)
846
757
+12 %
75% died before day:
927
875
+6 %
90% died before day:
1035
967
+7 %
Max lifespan observed (days)
1156
1216
Number of mice at start
57
125
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
NDGA effect on survival,
females, test site = UM
Log-rank test
chisq = 2.4271
p = 0.1193
Wang-Allison test
odds ratio = 1.7294
p = 0.3673
Quantiles
NDGA
Control
% difference
25% died before day:
802
772
+4 %
Median lifespan (days)
916
916
0 %
75% died before day:
1055
1005
+5 %
90% died before day:
1188
1111
+7 %
Max lifespan observed (days)
1249
1210
Number of mice at start
43
82
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
NDGA effect on survival,
males, test site = UM
Log-rank test
chisq = 1.5886
p = 0.2075
Wang-Allison test
odds ratio = 1.266
p = 0.7906
Quantiles
NDGA
Control
% difference
25% died before day:
776
727
+7 %
Median lifespan (days)
924
864
+7 %
75% died before day:
1052
995
+6 %
90% died before day:
1133
1121
+1 %
Max lifespan observed (days)
1267
1305
Number of mice at start
60
106
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
NDGA effect on survival,
females, test site = UT
Log-rank test
chisq = 0.7511
p = 0.3861
Wang-Allison test
odds ratio = 0.4689
p = 0.386
Quantiles
NDGA
Control
% difference
25% died before day:
719
744
-3 %
Median lifespan (days)
886
880
+1 %
75% died before day:
970
994
-2 %
90% died before day:
1051
1076
-2 %
Max lifespan observed (days)
1155
1188
Number of mice at start
48
96
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
NDGA effect on survival,
males, test site = UT
Log-rank test
chisq = 9.0875
p = 0.0026
Wang-Allison test
odds ratio = 1.307
p = 0.5889
Quantiles
NDGA
Control
% difference
25% died before day:
720
592
+22 %
Median lifespan (days)
858
739
+16 %
75% died before day:
974
877
+11 %
90% died before day:
1035
988
+5 %
Max lifespan observed (days)
1168
1132
Number of mice at start
52
119
Animal censor events are denoted by + marks in the plot
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National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions