An error occurred on this page. These results could be incomplete or invalid. Staff have been notified.
ITP survival analysis: minocycline
Intervention:
minocycline
antibiotic
Trial code: Min
Dose: 300 ppm
initiated at age: 6 mo
Sex: both
Cohort: C2015
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
Min effect on survival,
females, test site = All
Log-rank test
chisq = 0.7756
p = 0.3785
Wang-Allison test
odds ratio = 0.7907
p = 0.6048
Quantiles
Min
Control
% difference
25% died before day:
769
786
-2 %
Median lifespan (days)
878
904
-3 %
75% died before day:
1018
1016
0 %
90% died before day:
1094
1095
0 %
Max lifespan observed (days)
1263
1396
Number of mice at start
135
274
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
Min effect on survival,
males, test site = All
Log-rank test
chisq = 0.0001
p = 0.9922
Wang-Allison test
odds ratio = 0.7095
p = 0.3937
Quantiles
Min
Control
% difference
25% died before day:
630
581
+8 %
Median lifespan (days)
806
772
+4 %
75% died before day:
937
918
+2 %
90% died before day:
1026
1049
-2 %
Max lifespan observed (days)
1314
1237
Number of mice at start
150
264
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
Min effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.088
p = 0.7667
Wang-Allison test
odds ratio = 0.6959
p = 0.7736
Quantiles
Min
Control
% difference
25% died before day:
802
785
+2 %
Median lifespan (days)
922
928
-1 %
75% died before day:
1066
1043
+2 %
90% died before day:
1116
1156
-3 %
Max lifespan observed (days)
1231
1396
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
Min effect on survival,
males, test site = TJL
Log-rank test
chisq = 1.0546
p = 0.3045
Wang-Allison test
odds ratio = 0.5911
p = 0.5735
Quantiles
Min
Control
% difference
25% died before day:
638
608
+5 %
Median lifespan (days)
808
818
-1 %
75% died before day:
939
942
0 %
90% died before day:
1028
1061
-3 %
Max lifespan observed (days)
1155
1237
Number of mice at start
54
92
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
Min effect on survival,
females, test site = UM
Log-rank test
chisq = 2.4775
p = 0.1155
Wang-Allison test
odds ratio = 0.5344
p = 0.5479
Quantiles
Min
Control
% difference
25% died before day:
752
791
-5 %
Median lifespan (days)
825
899
-8 %
75% died before day:
950
992
-4 %
90% died before day:
1050
1079
-3 %
Max lifespan observed (days)
1171
1291
Number of mice at start
44
91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
Min effect on survival,
males, test site = UM
Log-rank test
chisq = 0.5838
p = 0.4448
Wang-Allison test
odds ratio = 0.9007
p = 1.0
Quantiles
Min
Control
% difference
25% died before day:
644
601
+7 %
Median lifespan (days)
844
740
+14 %
75% died before day:
954
905
+5 %
90% died before day:
1027
1027
0 %
Max lifespan observed (days)
1197
1231
Number of mice at start
45
81
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
Min effect on survival,
females, test site = UT
Log-rank test
chisq = 0.0806
p = 0.7765
Wang-Allison test
odds ratio = 1.2966
p = 0.758
Quantiles
Min
Control
% difference
25% died before day:
801
786
+2 %
Median lifespan (days)
887
892
-1 %
75% died before day:
993
1014
-2 %
90% died before day:
1100
1078
+2 %
Max lifespan observed (days)
1263
1280
Number of mice at start
43
88
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
Min effect on survival,
males, test site = UT
Log-rank test
chisq = 0.0928
p = 0.7607
Wang-Allison test
odds ratio = 0.6974
p = 0.7701
Quantiles
Min
Control
% difference
25% died before day:
506
500
+1 %
Median lifespan (days)
769
786
-2 %
75% died before day:
893
888
+1 %
90% died before day:
987
1025
-4 %
Max lifespan observed (days)
1314
1220
Number of mice at start
51
91
Animal censor events are denoted by + marks in the plot
See our
ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions