ITP survival analysis:   minocycline

Intervention:   minocycline     antibiotic
Trial code: Min Dose: 300 ppm initiated at age: 6 mo Sex: both Cohort: C2015
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
Min effect on survival, females, test site = All
Log-rank test chisq = 0.7756 p = 0.3785
Wang-Allison test odds ratio = 0.7907 p = 0.6048
Quantiles Min Control % difference
25% died before day: 769 786 -2 %
Median lifespan (days) 878 904 -3 %
75% died before day: 1018 1016 0 %
90% died before day: 1094 1095 0 %
Max lifespan observed (days) 1263 1396
Number of mice at start 135 274
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Min effect on survival, males, test site = All
Log-rank test chisq = 0.0001 p = 0.9922
Wang-Allison test odds ratio = 0.7095 p = 0.3937
Quantiles Min Control % difference
25% died before day: 630 581 +8 %
Median lifespan (days) 806 772 +4 %
75% died before day: 937 918 +2 %
90% died before day: 1026 1049 -2 %
Max lifespan observed (days) 1314 1237
Number of mice at start 150 264
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
Min effect on survival, females, test site = TJL
Log-rank test chisq = 0.088 p = 0.7667
Wang-Allison test odds ratio = 0.6959 p = 0.7736
Quantiles Min Control % difference
25% died before day: 802 785 +2 %
Median lifespan (days) 922 928 -1 %
75% died before day: 1066 1043 +2 %
90% died before day: 1116 1156 -3 %
Max lifespan observed (days) 1231 1396
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
Min effect on survival, males, test site = TJL
Log-rank test chisq = 1.0546 p = 0.3045
Wang-Allison test odds ratio = 0.5911 p = 0.5735
Quantiles Min Control % difference
25% died before day: 638 608 +5 %
Median lifespan (days) 808 818 -1 %
75% died before day: 939 942 0 %
90% died before day: 1028 1061 -3 %
Max lifespan observed (days) 1155 1237
Number of mice at start 54 92
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
Min effect on survival, females, test site = UM
Log-rank test chisq = 2.4775 p = 0.1155
Wang-Allison test odds ratio = 0.5344 p = 0.5479
Quantiles Min Control % difference
25% died before day: 752 791 -5 %
Median lifespan (days) 825 899 -8 %
75% died before day: 950 992 -4 %
90% died before day: 1050 1079 -3 %
Max lifespan observed (days) 1171 1291
Number of mice at start 44 91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
Min effect on survival, males, test site = UM
Log-rank test chisq = 0.5838 p = 0.4448
Wang-Allison test odds ratio = 0.9007 p = 1.0
Quantiles Min Control % difference
25% died before day: 644 601 +7 %
Median lifespan (days) 844 740 +14 %
75% died before day: 954 905 +5 %
90% died before day: 1027 1027 0 %
Max lifespan observed (days) 1197 1231
Number of mice at start 45 81
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
Min effect on survival, females, test site = UT
Log-rank test chisq = 0.0806 p = 0.7765
Wang-Allison test odds ratio = 1.2966 p = 0.758
Quantiles Min Control % difference
25% died before day: 801 786 +2 %
Median lifespan (days) 887 892 -1 %
75% died before day: 993 1014 -2 %
90% died before day: 1100 1078 +2 %
Max lifespan observed (days) 1263 1280
Number of mice at start 43 88
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
Min effect on survival, males, test site = UT
Log-rank test chisq = 0.0928 p = 0.7607
Wang-Allison test odds ratio = 0.6974 p = 0.7701
Quantiles Min Control % difference
25% died before day: 506 500 +1 %
Median lifespan (days) 769 786 -2 %
75% died before day: 893 888 +1 %
90% died before day: 987 1025 -4 %
Max lifespan observed (days) 1314 1220
Number of mice at start 51 91
Animal censor events are denoted by + marks in the plot


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Statistical definitions