An error occurred on this page.
These results could be incomplete or invalid. Staff have been notified.



ITP survival analysis:   minocycline

Intervention:   minocycline     antibiotic
Trial code: Min Dose: 300 ppm initiated at age: 6 mo Sex: both Cohort: C2015
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
Min effect on survival, females, test site = All
Log-rank test chisq = 0.7756 p = 0.3785
Wang-Allison test odds ratio = 0.7907 p = 0.6048
Quantiles Min Control % difference
25% died before day: 769 786 -2 %
Median lifespan (days) 878 904 -3 %
75% died before day: 1018 1016 0 %
90% died before day: 1094 1095 0 %
Max lifespan observed (days) 1263 1396
Number of mice at start 135 274
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Min effect on survival, males, test site = All
Log-rank test chisq = 0.0001 p = 0.9922
Wang-Allison test odds ratio = 0.7095 p = 0.3937
Quantiles Min Control % difference
25% died before day: 630 581 +8 %
Median lifespan (days) 806 772 +4 %
75% died before day: 937 918 +2 %
90% died before day: 1026 1049 -2 %
Max lifespan observed (days) 1314 1237
Number of mice at start 150 264
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
Min effect on survival, females, test site = TJL
Log-rank test chisq = 0.088 p = 0.7667
Wang-Allison test odds ratio = 0.6959 p = 0.7736
Quantiles Min Control % difference
25% died before day: 802 785 +2 %
Median lifespan (days) 922 928 -1 %
75% died before day: 1066 1043 +2 %
90% died before day: 1116 1156 -3 %
Max lifespan observed (days) 1231 1396
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
Min effect on survival, males, test site = TJL
Log-rank test chisq = 1.0546 p = 0.3045
Wang-Allison test odds ratio = 0.5911 p = 0.5735
Quantiles Min Control % difference
25% died before day: 638 608 +5 %
Median lifespan (days) 808 818 -1 %
75% died before day: 939 942 0 %
90% died before day: 1028 1061 -3 %
Max lifespan observed (days) 1155 1237
Number of mice at start 54 92
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
Min effect on survival, females, test site = UM
Log-rank test chisq = 2.4775 p = 0.1155
Wang-Allison test odds ratio = 0.5344 p = 0.5479
Quantiles Min Control % difference
25% died before day: 752 791 -5 %
Median lifespan (days) 825 899 -8 %
75% died before day: 950 992 -4 %
90% died before day: 1050 1079 -3 %
Max lifespan observed (days) 1171 1291
Number of mice at start 44 91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
Min effect on survival, males, test site = UM
Log-rank test chisq = 0.5838 p = 0.4448
Wang-Allison test odds ratio = 0.9007 p = 1.0
Quantiles Min Control % difference
25% died before day: 644 601 +7 %
Median lifespan (days) 844 740 +14 %
75% died before day: 954 905 +5 %
90% died before day: 1027 1027 0 %
Max lifespan observed (days) 1197 1231
Number of mice at start 45 81
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
Min effect on survival, females, test site = UT
Log-rank test chisq = 0.0806 p = 0.7765
Wang-Allison test odds ratio = 1.2966 p = 0.758
Quantiles Min Control % difference
25% died before day: 801 786 +2 %
Median lifespan (days) 887 892 -1 %
75% died before day: 993 1014 -2 %
90% died before day: 1100 1078 +2 %
Max lifespan observed (days) 1263 1280
Number of mice at start 43 88
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
Min effect on survival, males, test site = UT
Log-rank test chisq = 0.0928 p = 0.7607
Wang-Allison test odds ratio = 0.6974 p = 0.7701
Quantiles Min Control % difference
25% died before day: 506 500 +1 %
Median lifespan (days) 769 786 -2 %
75% died before day: 893 888 +1 %
90% died before day: 987 1025 -4 %
Max lifespan observed (days) 1314 1220
Number of mice at start 51 91
Animal censor events are denoted by + marks in the plot


See our ITP data portal page for more information on National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.

Statistical definitions