ITP survival analysis: 3-(3-hydroxybenzyl)-5-methylbenzo[d]oxazol-2(3H)-one
Intervention:
3-(3-hydroxybenzyl)-5-methylbenzo[d]oxazol-2(3H)-one
proinflammatory cytokine antagonist
Trial code: MIF098
Dose: 240 ppm
initiated at age: 8 mo
Sex: both
Cohort: C2016
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
MIF098 effect on survival,
females, test site = All
Log-rank test
chisq = 3.3125
p = 0.0688
Wang-Allison test
odds ratio = 0.7152
p = 0.3954
Quantiles
MIF098
Control
% difference
25% died before day:
750
790
-5 %
Median lifespan (days)
862
875
-1 %
75% died before day:
957
975
-2 %
90% died before day:
1026
1055
-3 %
Max lifespan observed (days)
1222
1339
Number of mice at start
136
303
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
MIF098 effect on survival,
males, test site = All
Log-rank test
chisq = 0.2126
p = 0.6447
Wang-Allison test
odds ratio = 1.0101
p = 1.0
Quantiles
MIF098
Control
% difference
25% died before day:
658
608
+8 %
Median lifespan (days)
822
782
+5 %
75% died before day:
964
935
+3 %
90% died before day:
1058
1055
0 %
Max lifespan observed (days)
1167
1264
Number of mice at start
146
275
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
MIF098 effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.0673
p = 0.7953
Wang-Allison test
odds ratio = 0.9885
p = 1.0
Quantiles
MIF098
Control
% difference
25% died before day:
758
816
-7 %
Median lifespan (days)
886
883
0 %
75% died before day:
962
971
-1 %
90% died before day:
1062
1057
0 %
Max lifespan observed (days)
1222
1230
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
MIF098 effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.7507
p = 0.3862
Wang-Allison test
odds ratio = 1.2855
p = 0.7755
Quantiles
MIF098
Control
% difference
25% died before day:
622
608
+2 %
Median lifespan (days)
829
749
+11 %
75% died before day:
964
891
+8 %
90% died before day:
1045
1005
+4 %
Max lifespan observed (days)
1140
1262
Number of mice at start
50
94
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
MIF098 effect on survival,
females, test site = UM
Log-rank test
chisq = 2.9893
p = 0.0838
Wang-Allison test
odds ratio = 0.3197
p = 0.2256
Quantiles
MIF098
Control
% difference
25% died before day:
720
788
-9 %
Median lifespan (days)
836
858
-3 %
75% died before day:
928
961
-3 %
90% died before day:
986
1034
-5 %
Max lifespan observed (days)
1042
1189
Number of mice at start
44
92
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
MIF098 effect on survival,
males, test site = UM
Log-rank test
chisq = 0.2361
p = 0.627
Wang-Allison test
odds ratio = 0.5167
p = 0.3787
Quantiles
MIF098
Control
% difference
25% died before day:
686
534
+28 %
Median lifespan (days)
807
814
-1 %
75% died before day:
968
996
-3 %
90% died before day:
1039
1071
-3 %
Max lifespan observed (days)
1167
1258
Number of mice at start
45
82
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
MIF098 effect on survival,
females, test site = UT
Log-rank test
chisq = 1.5445
p = 0.2139
Wang-Allison test
odds ratio = 0.9367
p = 1.0
Quantiles
MIF098
Control
% difference
25% died before day:
720
774
-7 %
Median lifespan (days)
866
882
-2 %
75% died before day:
956
984
-3 %
90% died before day:
1036
1058
-2 %
Max lifespan observed (days)
1117
1339
Number of mice at start
44
116
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
MIF098 effect on survival,
males, test site = UT
Log-rank test
chisq = 0.1247
p = 0.724
Wang-Allison test
odds ratio = 1.3306
p = 0.5807
Quantiles
MIF098
Control
% difference
25% died before day:
667
640
+4 %
Median lifespan (days)
826
799
+3 %
75% died before day:
955
936
+2 %
90% died before day:
1080
1064
+2 %
Max lifespan observed (days)
1161
1264
Number of mice at start
51
99
Animal censor events are denoted by + marks in the plot
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Statistical definitions