ITP survival analysis: medium-chain triglyceride oil
Intervention:
medium-chain triglyceride oil
Trial code: MCTO
Dose: 60,000 ppm
initiated at age: 4 mo
Sex: both
Cohort: C2007
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
MCTO effect on survival,
females, test site = All
Log-rank test
chisq = 2.0662
p = 0.1506
Wang-Allison test
odds ratio = 1.4897
p = 0.2281
Quantiles
MCTO
Control
% difference
25% died before day:
766
753
+2 %
Median lifespan (days)
882
865
+2 %
75% died before day:
1022
994
+3 %
90% died before day:
1116
1088
+3 %
Max lifespan observed (days)
1322
1359
Number of mice at start
131
275
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
MCTO effect on survival,
males, test site = All
Log-rank test
chisq = 0.6601
p = 0.4165
Wang-Allison test
odds ratio = 1.3577
p = 0.4007
Quantiles
MCTO
Control
% difference
25% died before day:
572
588
-3 %
Median lifespan (days)
777
784
-1 %
75% died before day:
974
954
+2 %
90% died before day:
1100
1074
+2 %
Max lifespan observed (days)
1303
1247
Number of mice at start
153
276
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
MCTO effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.1134
p = 0.7363
Wang-Allison test
odds ratio = 0.8421
p = 1.0
Quantiles
MCTO
Control
% difference
25% died before day:
801
740
+8 %
Median lifespan (days)
899
860
+5 %
75% died before day:
1036
1016
+2 %
90% died before day:
1109
1111
0 %
Max lifespan observed (days)
1322
1340
Number of mice at start
43
92
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
MCTO effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.0045
p = 0.9465
Wang-Allison test
odds ratio = 0.9424
p = 1.0
Quantiles
MCTO
Control
% difference
25% died before day:
531
569
-7 %
Median lifespan (days)
738
728
+1 %
75% died before day:
895
923
-3 %
90% died before day:
1025
1039
-1 %
Max lifespan observed (days)
1203
1200
Number of mice at start
51
87
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
MCTO effect on survival,
females, test site = UM
Log-rank test
chisq = 0.9145
p = 0.3389
Wang-Allison test
odds ratio = 1.6318
p = 0.3835
Quantiles
MCTO
Control
% difference
25% died before day:
812
767
+6 %
Median lifespan (days)
904
900
0 %
75% died before day:
1047
999
+5 %
90% died before day:
1140
1114
+2 %
Max lifespan observed (days)
1249
1359
Number of mice at start
44
91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
MCTO effect on survival,
males, test site = UM
Log-rank test
chisq = 4.3054
p = 0.038
Wang-Allison test
odds ratio = 3.0806
p = 0.0466
Quantiles
MCTO
Control
% difference
25% died before day:
666
659
+1 %
Median lifespan (days)
860
793
+8 %
75% died before day:
1040
953
+9 %
90% died before day:
1150
1076
+7 %
Max lifespan observed (days)
1270
1191
Number of mice at start
51
93
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
MCTO effect on survival,
females, test site = UT
Log-rank test
chisq = 1.4125
p = 0.2346
Wang-Allison test
odds ratio = 2.2819
p = 0.1449
Quantiles
MCTO
Control
% difference
25% died before day:
731
756
-3 %
Median lifespan (days)
859
840
+2 %
75% died before day:
1014
962
+5 %
90% died before day:
1097
1045
+5 %
Max lifespan observed (days)
1266
1261
Number of mice at start
44
92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
MCTO effect on survival,
males, test site = UT
Log-rank test
chisq = 0.6032
p = 0.4374
Wang-Allison test
odds ratio = 0.7658
p = 0.7731
Quantiles
MCTO
Control
% difference
25% died before day:
552
584
-5 %
Median lifespan (days)
766
810
-5 %
75% died before day:
996
1010
-1 %
90% died before day:
1092
1132
-4 %
Max lifespan observed (days)
1303
1247
Number of mice at start
51
96
Animal censor events are denoted by + marks in the plot
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National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions