ITP survival analysis: methylene blue
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
MB effect on survival,
females, test site = All
Log-rank test
chisq = 2.2492
p = 0.1337
Wang-Allison test
odds ratio = 2.5698
p = 0.0074
Quantiles
MB
Control
% difference
25% died before day:
785
778
+1 %
Median lifespan (days)
902
881
+2 %
75% died before day:
1026
988
+4 %
90% died before day:
1133
1066
+6 %
Max lifespan observed (days)
1224
1229
Number of mice at start
135
242
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
MB effect on survival,
males, test site = All
Log-rank test
chisq = 1.3409
p = 0.2469
Wang-Allison test
odds ratio = 0.8037
p = 0.6173
Quantiles
MB
Control
% difference
25% died before day:
579
616
-6 %
Median lifespan (days)
788
807
-2 %
75% died before day:
922
973
-5 %
90% died before day:
1037
1094
-5 %
Max lifespan observed (days)
1291
1338
Number of mice at start
146
295
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
MB effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.0752
p = 0.784
Wang-Allison test
odds ratio = 1.6025
p = 0.5298
Quantiles
MB
Control
% difference
25% died before day:
785
768
+2 %
Median lifespan (days)
862
894
-4 %
75% died before day:
986
976
+1 %
90% died before day:
1121
1051
+7 %
Max lifespan observed (days)
1224
1197
Number of mice at start
47
60
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
MB effect on survival,
males, test site = TJL
Log-rank test
chisq = 3.0882
p = 0.0789
Wang-Allison test
odds ratio = 0.4003
p = 0.1783
Quantiles
MB
Control
% difference
25% died before day:
543
606
-10 %
Median lifespan (days)
701
807
-13 %
75% died before day:
877
941
-7 %
90% died before day:
1009
1061
-5 %
Max lifespan observed (days)
1100
1338
Number of mice at start
54
101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
MB effect on survival,
females, test site = UM
Log-rank test
chisq = 4.0941
p = 0.043
Wang-Allison test
odds ratio = 6.2244
p = 0.0021
Quantiles
MB
Control
% difference
25% died before day:
848
797
+6 %
Median lifespan (days)
996
886
+12 %
75% died before day:
1084
1008
+8 %
90% died before day:
1159
1088
+7 %
Max lifespan observed (days)
1210
1229
Number of mice at start
44
90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
MB effect on survival,
males, test site = UM
Log-rank test
chisq = 0.0574
p = 0.8107
Wang-Allison test
odds ratio = 1.3243
p = 0.7592
Quantiles
MB
Control
% difference
25% died before day:
798
742
+8 %
Median lifespan (days)
905
925
-2 %
75% died before day:
987
1077
-8 %
90% died before day:
1157
1151
+1 %
Max lifespan observed (days)
1291
1325
Number of mice at start
41
95
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
MB effect on survival,
females, test site = UT
Log-rank test
chisq = 0.0487
p = 0.8253
Wang-Allison test
odds ratio = 1.6514
p = 0.3802
Quantiles
MB
Control
% difference
25% died before day:
779
750
+4 %
Median lifespan (days)
884
866
+2 %
75% died before day:
993
994
0 %
90% died before day:
1075
1062
+1 %
Max lifespan observed (days)
1190
1213
Number of mice at start
44
92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
MB effect on survival,
males, test site = UT
Log-rank test
chisq = 0.0002
p = 0.9901
Wang-Allison test
odds ratio = 0.9676
p = 1.0
Quantiles
MB
Control
% difference
25% died before day:
529
497
+6 %
Median lifespan (days)
699
704
-1 %
75% died before day:
867
903
-4 %
90% died before day:
980
1013
-3 %
Max lifespan observed (days)
1172
1133
Number of mice at start
51
99
Animal censor events are denoted by + marks in the plot
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ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions