ITP survival analysis:   inulin

Intervention:   inulin     soluble fiber dietary supplement
Trial code: Inu Dose: 600 ppm initiated at age: 11 mo Sex: both Cohort: C2014
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
Inu effect on survival, females, test site = All
Log-rank test chisq = 0.6747 p = 0.4114
Wang-Allison test odds ratio = 0.9227 p = 0.864
Quantiles Inu Control % difference
25% died before day: 810 764 +6 %
Median lifespan (days) 911 897 +2 %
75% died before day: 1017 1018 0 %
90% died before day: 1120 1109 +1 %
Max lifespan observed (days) 1279 1358
Number of mice at start 135 279
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Inu effect on survival, males, test site = All
Log-rank test chisq = 0.1161 p = 0.7333
Wang-Allison test odds ratio = 1.794 p = 0.0883
Quantiles Inu Control % difference
25% died before day: 629 638 -1 %
Median lifespan (days) 815 832 -2 %
75% died before day: 941 969 -3 %
90% died before day: 1063 1059 0 %
Max lifespan observed (days) 1227 1272
Number of mice at start 141 273
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
Inu effect on survival, females, test site = TJL
Log-rank test chisq = 0.7835 p = 0.3761
Wang-Allison test odds ratio = 1.3778 p = 0.5725
Quantiles Inu Control % difference
25% died before day: 808 782 +3 %
Median lifespan (days) 919 904 +2 %
75% died before day: 1016 1010 +1 %
90% died before day: 1144 1099 +4 %
Max lifespan observed (days) 1225 1358
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
Inu effect on survival, males, test site = TJL
Log-rank test chisq = 0.5265 p = 0.4681
Wang-Allison test odds ratio = 1.6839 p = 0.396
Quantiles Inu Control % difference
25% died before day: 526 572 -8 %
Median lifespan (days) 782 873 -10 %
75% died before day: 952 992 -4 %
90% died before day: 1113 1068 +4 %
Max lifespan observed (days) 1217 1272
Number of mice at start 51 93
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
Inu effect on survival, females, test site = UM
Log-rank test chisq = 0.2794 p = 0.5971
Wang-Allison test odds ratio = 0.3234 p = 0.2246
Quantiles Inu Control % difference
25% died before day: 805 748 +8 %
Median lifespan (days) 921 884 +4 %
75% died before day: 1011 1016 0 %
90% died before day: 1063 1139 -7 %
Max lifespan observed (days) 1279 1210
Number of mice at start 43 91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
Inu effect on survival, males, test site = UM
Log-rank test chisq = 0.4675 p = 0.4941
Wang-Allison test odds ratio = 1.3931 p = 0.548
Quantiles Inu Control % difference
25% died before day: 771 756 +2 %
Median lifespan (days) 900 894 +1 %
75% died before day: 1018 1009 +1 %
90% died before day: 1136 1084 +5 %
Max lifespan observed (days) 1227 1206
Number of mice at start 39 84
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
Inu effect on survival, females, test site = UT
Log-rank test chisq = 0.0002 p = 0.9901
Wang-Allison test odds ratio = 1.3619 p = 0.7554
Quantiles Inu Control % difference
25% died before day: 816 768 +6 %
Median lifespan (days) 880 882 0 %
75% died before day: 1022 1046 -2 %
90% died before day: 1129 1109 +2 %
Max lifespan observed (days) 1201 1238
Number of mice at start 44 92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
Inu effect on survival, males, test site = UT
Log-rank test chisq = 0.4201 p = 0.5169
Wang-Allison test odds ratio = 2.3505 p = 0.1513
Quantiles Inu Control % difference
25% died before day: 603 570 +6 %
Median lifespan (days) 790 743 +6 %
75% died before day: 867 892 -3 %
90% died before day: 1035 977 +6 %
Max lifespan observed (days) 1221 1167
Number of mice at start 51 96
Animal censor events are denoted by + marks in the plot


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Statistical definitions