ITP survival analysis:   geranylgeranyl acetone

Intervention:   geranylgeranyl acetone     induces heat shock protein HSP70
Trial code: GGA Dose: 600 ppm initiated at age: 9 mo Sex: both Cohort: C2016
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
GGA effect on survival, females, test site = All
Log-rank test chisq = 0.1284 p = 0.7201
Wang-Allison test odds ratio = 1.5577 p = 0.176
Quantiles GGA Control % difference
25% died before day: 792 790 0 %
Median lifespan (days) 895 875 +2 %
75% died before day: 990 975 +2 %
90% died before day: 1069 1055 +1 %
Max lifespan observed (days) 1220 1339
Number of mice at start 136 303
Animal censor events are denoted by + marks in the plot
All test sites combined – male
GGA effect on survival, males, test site = All
Log-rank test chisq = 0.1282 p = 0.7203
Wang-Allison test odds ratio = 1.1477 p = 0.7297
Quantiles GGA Control % difference
25% died before day: 671 608 +10 %
Median lifespan (days) 813 782 +4 %
75% died before day: 930 935 -1 %
90% died before day: 1045 1055 -1 %
Max lifespan observed (days) 1214 1264
Number of mice at start 135 275
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
GGA effect on survival, females, test site = TJL
Log-rank test chisq = 0.0307 p = 0.8609
Wang-Allison test odds ratio = 1.3621 p = 0.5749
Quantiles GGA Control % difference
25% died before day: 802 816 -2 %
Median lifespan (days) 892 883 +1 %
75% died before day: 991 971 +2 %
90% died before day: 1089 1057 +3 %
Max lifespan observed (days) 1220 1230
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
GGA effect on survival, males, test site = TJL
Log-rank test chisq = 0.0389 p = 0.8436
Wang-Allison test odds ratio = 0.858 p = 1.0
Quantiles GGA Control % difference
25% died before day: 672 608 +11 %
Median lifespan (days) 787 749 +5 %
75% died before day: 868 891 -3 %
90% died before day: 995 1005 -1 %
Max lifespan observed (days) 1214 1262
Number of mice at start 54 94
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
GGA effect on survival, females, test site = UM
Log-rank test chisq = 0.3456 p = 0.5566
Wang-Allison test odds ratio = 2.2819 p = 0.1449
Quantiles GGA Control % difference
25% died before day: 752 788 -5 %
Median lifespan (days) 898 858 +5 %
75% died before day: 992 961 +3 %
90% died before day: 1064 1034 +3 %
Max lifespan observed (days) 1092 1189
Number of mice at start 44 92
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
GGA effect on survival, males, test site = UM
Log-rank test chisq = 1.0524 p = 0.305
Wang-Allison test odds ratio = 1.9015 p = 0.321
Quantiles GGA Control % difference
25% died before day: 747 534 +40 %
Median lifespan (days) 887 814 +9 %
75% died before day: 1004 996 +1 %
90% died before day: 1114 1071 +4 %
Max lifespan observed (days) 1147 1258
Number of mice at start 33 82
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
GGA effect on survival, females, test site = UT
Log-rank test chisq = 0.0179 p = 0.8935
Wang-Allison test odds ratio = 1.2221 p = 0.77
Quantiles GGA Control % difference
25% died before day: 772 774 0 %
Median lifespan (days) 892 882 +1 %
75% died before day: 976 984 -1 %
90% died before day: 1090 1058 +3 %
Max lifespan observed (days) 1173 1339
Number of mice at start 44 116
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
GGA effect on survival, males, test site = UT
Log-rank test chisq = 0.0112 p = 0.9158
Wang-Allison test odds ratio = 1.0346 p = 1.0
Quantiles GGA Control % difference
25% died before day: 614 640 -4 %
Median lifespan (days) 800 799 0 %
75% died before day: 935 936 0 %
90% died before day: 1102 1064 +4 %
Max lifespan observed (days) 1188 1264
Number of mice at start 48 99
Animal censor events are denoted by + marks in the plot


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Statistical definitions