ITP survival analysis: fish oil
Intervention:
fish oil
source of omega-3 fatty acids
Trial code: FO_lo
Dose: 15,000 ppm
initiated at age: 9 mo
Sex: both
Cohort: C2010
Trial code: FO_hi
Dose: 50,000 ppm
initiated at age: 9 mo
Sex: both
Cohort: C2010
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
FO_lo effect on survival,
females, test site = All
Log-rank test
chisq = 2.8802
p = 0.0897
Wang-Allison test
odds ratio = 0.7372
p = 0.4815
Quantiles
FO_lo
Control
% difference
25% died before day:
772
786
-2 %
Median lifespan (days)
858
896
-4 %
75% died before day:
994
1034
-4 %
90% died before day:
1082
1116
-3 %
Max lifespan observed (days)
1300
1298
Number of mice at start
132
264
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival,
females, test site = All
Log-rank test
chisq = 1.3433
p = 0.2465
Wang-Allison test
odds ratio = 0.7164
p = 0.4814
Quantiles
FO_hi
Control
% difference
25% died before day:
798
786
+2 %
Median lifespan (days)
923
896
+3 %
75% died before day:
1008
1034
-3 %
90% died before day:
1088
1116
-3 %
Max lifespan observed (days)
1219
1298
Number of mice at start
135
264
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
FO_lo effect on survival,
males, test site = All
Log-rank test
chisq = 1.2542
p = 0.2627
Wang-Allison test
odds ratio = 1.08
p = 0.8642
Quantiles
FO_lo
Control
% difference
25% died before day:
628
586
+7 %
Median lifespan (days)
810
777
+4 %
75% died before day:
980
953
+3 %
90% died before day:
1068
1090
-2 %
Max lifespan observed (days)
1308
1309
Number of mice at start
141
274
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival,
males, test site = All
Log-rank test
chisq = 1.5184
p = 0.2179
Wang-Allison test
odds ratio = 0.6778
p = 0.3174
Quantiles
FO_hi
Control
% difference
25% died before day:
570
586
-3 %
Median lifespan (days)
732
777
-6 %
75% died before day:
910
953
-5 %
90% died before day:
1046
1090
-4 %
Max lifespan observed (days)
1225
1309
Number of mice at start
146
274
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
FO_lo effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.4661
p = 0.4948
Wang-Allison test
odds ratio = 0.7642
p = 0.7725
Quantiles
FO_lo
Control
% difference
25% died before day:
806
774
+4 %
Median lifespan (days)
852
864
-1 %
75% died before day:
964
993
-3 %
90% died before day:
1053
1102
-4 %
Max lifespan observed (days)
1300
1222
Number of mice at start
47
92
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.0102
p = 0.9196
Wang-Allison test
odds ratio = 0.747
p = 0.7715
Quantiles
FO_hi
Control
% difference
25% died before day:
806
774
+4 %
Median lifespan (days)
918
864
+6 %
75% died before day:
988
993
-1 %
90% died before day:
1085
1102
-2 %
Max lifespan observed (days)
1218
1222
Number of mice at start
48
92
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
FO_lo effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.0343
p = 0.8531
Wang-Allison test
odds ratio = 0.6974
p = 0.7701
Quantiles
FO_lo
Control
% difference
25% died before day:
536
498
+8 %
Median lifespan (days)
736
683
+8 %
75% died before day:
880
819
+7 %
90% died before day:
1046
1067
-2 %
Max lifespan observed (days)
1274
1309
Number of mice at start
50
91
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.5835
p = 0.4449
Wang-Allison test
odds ratio = 0.6209
p = 0.573
Quantiles
FO_hi
Control
% difference
25% died before day:
512
498
+3 %
Median lifespan (days)
789
683
+16 %
75% died before day:
924
819
+13 %
90% died before day:
1025
1067
-4 %
Max lifespan observed (days)
1225
1309
Number of mice at start
51
91
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
FO_lo effect on survival,
females, test site = UM
Log-rank test
chisq = 2.6069
p = 0.1064
Wang-Allison test
odds ratio = 0.3614
p = 0.224
Quantiles
FO_lo
Control
% difference
25% died before day:
783
811
-3 %
Median lifespan (days)
873
930
-6 %
75% died before day:
986
1064
-7 %
90% died before day:
1089
1132
-4 %
Max lifespan observed (days)
1139
1255
Number of mice at start
41
88
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival,
females, test site = UM
Log-rank test
chisq = 0.1082
p = 0.7422
Wang-Allison test
odds ratio = 0.8897
p = 1.0
Quantiles
FO_hi
Control
% difference
25% died before day:
850
811
+5 %
Median lifespan (days)
947
930
+2 %
75% died before day:
1019
1064
-4 %
90% died before day:
1100
1132
-3 %
Max lifespan observed (days)
1219
1255
Number of mice at start
43
88
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
FO_lo effect on survival,
males, test site = UM
Log-rank test
chisq = 0.0547
p = 0.815
Wang-Allison test
odds ratio = 0.8897
p = 1.0
Quantiles
FO_lo
Control
% difference
25% died before day:
759
794
-4 %
Median lifespan (days)
951
926
+3 %
75% died before day:
1024
1050
-2 %
90% died before day:
1061
1146
-7 %
Max lifespan observed (days)
1215
1294
Number of mice at start
43
88
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival,
males, test site = UM
Log-rank test
chisq = 8.5456
p = 0.0035
Wang-Allison test
odds ratio = 0.5145
p = 0.3839
Quantiles
FO_hi
Control
% difference
25% died before day:
576
794
-27 %
Median lifespan (days)
754
926
-19 %
75% died before day:
957
1050
-9 %
90% died before day:
1058
1146
-8 %
Max lifespan observed (days)
1159
1294
Number of mice at start
44
88
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
FO_lo effect on survival,
females, test site = UT
Log-rank test
chisq = 0.4847
p = 0.4863
Wang-Allison test
odds ratio = 1.216
p = 0.7639
Quantiles
FO_lo
Control
% difference
25% died before day:
730
773
-6 %
Median lifespan (days)
831
906
-8 %
75% died before day:
1025
1021
0 %
90% died before day:
1109
1100
+1 %
Max lifespan observed (days)
1274
1298
Number of mice at start
44
84
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival,
females, test site = UT
Log-rank test
chisq = 2.7503
p = 0.0972
Wang-Allison test
odds ratio = 0.5438
p = 0.5403
Quantiles
FO_hi
Control
% difference
25% died before day:
709
773
-8 %
Median lifespan (days)
892
906
-2 %
75% died before day:
1002
1021
-2 %
90% died before day:
1067
1100
-3 %
Max lifespan observed (days)
1124
1298
Number of mice at start
44
84
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
FO_lo effect on survival,
males, test site = UT
Log-rank test
chisq = 3.6796
p = 0.0551
Wang-Allison test
odds ratio = 1.8482
p = 0.2625
Quantiles
FO_lo
Control
% difference
25% died before day:
525
527
0 %
Median lifespan (days)
801
732
+9 %
75% died before day:
982
889
+10 %
90% died before day:
1128
1041
+8 %
Max lifespan observed (days)
1308
1155
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival,
males, test site = UT
Log-rank test
chisq = 0.1277
p = 0.7209
Wang-Allison test
odds ratio = 0.9244
p = 1.0
Quantiles
FO_hi
Control
% difference
25% died before day:
554
527
+5 %
Median lifespan (days)
703
732
-4 %
75% died before day:
883
889
-1 %
90% died before day:
1038
1041
0 %
Max lifespan observed (days)
1206
1155
Number of mice at start
51
95
Animal censor events are denoted by + marks in the plot
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Statistical definitions