ITP survival analysis:   fish oil

Intervention:   fish oil     source of omega-3 fatty acids
Trial code: FO_lo Dose: 15,000 ppm initiated at age: 9 mo Sex: both Cohort: C2010
Trial code: FO_hi Dose: 50,000 ppm initiated at age: 9 mo Sex: both Cohort: C2010
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
FO_lo effect on survival, females, test site = All
Log-rank test chisq = 2.8802 p = 0.0897
Wang-Allison test odds ratio = 0.7372 p = 0.4815
Quantiles FO_lo Control % difference
25% died before day: 772 786 -2 %
Median lifespan (days) 858 896 -4 %
75% died before day: 994 1034 -4 %
90% died before day: 1082 1116 -3 %
Max lifespan observed (days) 1300 1298
Number of mice at start 132 264
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival, females, test site = All
Log-rank test chisq = 1.3433 p = 0.2465
Wang-Allison test odds ratio = 0.7164 p = 0.4814
Quantiles FO_hi Control % difference
25% died before day: 798 786 +2 %
Median lifespan (days) 923 896 +3 %
75% died before day: 1008 1034 -3 %
90% died before day: 1088 1116 -3 %
Max lifespan observed (days) 1219 1298
Number of mice at start 135 264
Animal censor events are denoted by + marks in the plot
All test sites combined – male
FO_lo effect on survival, males, test site = All
Log-rank test chisq = 1.2542 p = 0.2627
Wang-Allison test odds ratio = 1.08 p = 0.8642
Quantiles FO_lo Control % difference
25% died before day: 628 586 +7 %
Median lifespan (days) 810 777 +4 %
75% died before day: 980 953 +3 %
90% died before day: 1068 1090 -2 %
Max lifespan observed (days) 1308 1309
Number of mice at start 141 274
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival, males, test site = All
Log-rank test chisq = 1.5184 p = 0.2179
Wang-Allison test odds ratio = 0.6778 p = 0.3174
Quantiles FO_hi Control % difference
25% died before day: 570 586 -3 %
Median lifespan (days) 732 777 -6 %
75% died before day: 910 953 -5 %
90% died before day: 1046 1090 -4 %
Max lifespan observed (days) 1225 1309
Number of mice at start 146 274
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
FO_lo effect on survival, females, test site = TJL
Log-rank test chisq = 0.4661 p = 0.4948
Wang-Allison test odds ratio = 0.7642 p = 0.7725
Quantiles FO_lo Control % difference
25% died before day: 806 774 +4 %
Median lifespan (days) 852 864 -1 %
75% died before day: 964 993 -3 %
90% died before day: 1053 1102 -4 %
Max lifespan observed (days) 1300 1222
Number of mice at start 47 92
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival, females, test site = TJL
Log-rank test chisq = 0.0102 p = 0.9196
Wang-Allison test odds ratio = 0.747 p = 0.7715
Quantiles FO_hi Control % difference
25% died before day: 806 774 +4 %
Median lifespan (days) 918 864 +6 %
75% died before day: 988 993 -1 %
90% died before day: 1085 1102 -2 %
Max lifespan observed (days) 1218 1222
Number of mice at start 48 92
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
FO_lo effect on survival, males, test site = TJL
Log-rank test chisq = 0.0343 p = 0.8531
Wang-Allison test odds ratio = 0.6974 p = 0.7701
Quantiles FO_lo Control % difference
25% died before day: 536 498 +8 %
Median lifespan (days) 736 683 +8 %
75% died before day: 880 819 +7 %
90% died before day: 1046 1067 -2 %
Max lifespan observed (days) 1274 1309
Number of mice at start 50 91
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival, males, test site = TJL
Log-rank test chisq = 0.5835 p = 0.4449
Wang-Allison test odds ratio = 0.6209 p = 0.573
Quantiles FO_hi Control % difference
25% died before day: 512 498 +3 %
Median lifespan (days) 789 683 +16 %
75% died before day: 924 819 +13 %
90% died before day: 1025 1067 -4 %
Max lifespan observed (days) 1225 1309
Number of mice at start 51 91
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
FO_lo effect on survival, females, test site = UM
Log-rank test chisq = 2.6069 p = 0.1064
Wang-Allison test odds ratio = 0.3614 p = 0.224
Quantiles FO_lo Control % difference
25% died before day: 783 811 -3 %
Median lifespan (days) 873 930 -6 %
75% died before day: 986 1064 -7 %
90% died before day: 1089 1132 -4 %
Max lifespan observed (days) 1139 1255
Number of mice at start 41 88
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival, females, test site = UM
Log-rank test chisq = 0.1082 p = 0.7422
Wang-Allison test odds ratio = 0.8897 p = 1.0
Quantiles FO_hi Control % difference
25% died before day: 850 811 +5 %
Median lifespan (days) 947 930 +2 %
75% died before day: 1019 1064 -4 %
90% died before day: 1100 1132 -3 %
Max lifespan observed (days) 1219 1255
Number of mice at start 43 88
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
FO_lo effect on survival, males, test site = UM
Log-rank test chisq = 0.0547 p = 0.815
Wang-Allison test odds ratio = 0.8897 p = 1.0
Quantiles FO_lo Control % difference
25% died before day: 759 794 -4 %
Median lifespan (days) 951 926 +3 %
75% died before day: 1024 1050 -2 %
90% died before day: 1061 1146 -7 %
Max lifespan observed (days) 1215 1294
Number of mice at start 43 88
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival, males, test site = UM
Log-rank test chisq = 8.5456 p = 0.0035
Wang-Allison test odds ratio = 0.5145 p = 0.3839
Quantiles FO_hi Control % difference
25% died before day: 576 794 -27 %
Median lifespan (days) 754 926 -19 %
75% died before day: 957 1050 -9 %
90% died before day: 1058 1146 -8 %
Max lifespan observed (days) 1159 1294
Number of mice at start 44 88
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
FO_lo effect on survival, females, test site = UT
Log-rank test chisq = 0.4847 p = 0.4863
Wang-Allison test odds ratio = 1.216 p = 0.7639
Quantiles FO_lo Control % difference
25% died before day: 730 773 -6 %
Median lifespan (days) 831 906 -8 %
75% died before day: 1025 1021 0 %
90% died before day: 1109 1100 +1 %
Max lifespan observed (days) 1274 1298
Number of mice at start 44 84
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival, females, test site = UT
Log-rank test chisq = 2.7503 p = 0.0972
Wang-Allison test odds ratio = 0.5438 p = 0.5403
Quantiles FO_hi Control % difference
25% died before day: 709 773 -8 %
Median lifespan (days) 892 906 -2 %
75% died before day: 1002 1021 -2 %
90% died before day: 1067 1100 -3 %
Max lifespan observed (days) 1124 1298
Number of mice at start 44 84
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
FO_lo effect on survival, males, test site = UT
Log-rank test chisq = 3.6796 p = 0.0551
Wang-Allison test odds ratio = 1.8482 p = 0.2625
Quantiles FO_lo Control % difference
25% died before day: 525 527 0 %
Median lifespan (days) 801 732 +9 %
75% died before day: 982 889 +10 %
90% died before day: 1128 1041 +8 %
Max lifespan observed (days) 1308 1155
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
FO_hi effect on survival, males, test site = UT
Log-rank test chisq = 0.1277 p = 0.7209
Wang-Allison test odds ratio = 0.9244 p = 1.0
Quantiles FO_hi Control % difference
25% died before day: 554 527 +5 %
Median lifespan (days) 703 732 -4 %
75% died before day: 883 889 -1 %
90% died before day: 1038 1041 0 %
Max lifespan observed (days) 1206 1155
Number of mice at start 51 95
Animal censor events are denoted by + marks in the plot


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Statistical definitions