ITP survival analysis: 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride
Intervention:
17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride
heat shock protein 90 inhibitor
Trial code: DMAG
Dose: 30 ppm
initiated at age: 6 mo
Sex: both
Cohort: C2015
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
DMAG effect on survival,
females, test site = All
Log-rank test
chisq = 2.3995
p = 0.1214
Wang-Allison test
odds ratio = 0.7132
p = 0.39
Quantiles
DMAG
Control
% difference
25% died before day:
732
786
-7 %
Median lifespan (days)
866
904
-4 %
75% died before day:
992
1016
-2 %
90% died before day:
1074
1095
-2 %
Max lifespan observed (days)
1219
1396
Number of mice at start
132
274
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
DMAG effect on survival,
males, test site = All
Log-rank test
chisq = 2.4526
p = 0.1173
Wang-Allison test
odds ratio = 1.1523
p = 0.7385
Quantiles
DMAG
Control
% difference
25% died before day:
642
581
+10 %
Median lifespan (days)
844
772
+9 %
75% died before day:
988
918
+8 %
90% died before day:
1090
1049
+4 %
Max lifespan observed (days)
1221
1237
Number of mice at start
152
264
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
DMAG effect on survival,
females, test site = TJL
Log-rank test
chisq = 1.0435
p = 0.307
Wang-Allison test
odds ratio = 0.5476
p = 0.5482
Quantiles
DMAG
Control
% difference
25% died before day:
731
785
-7 %
Median lifespan (days)
903
928
-3 %
75% died before day:
1035
1043
-1 %
90% died before day:
1091
1156
-6 %
Max lifespan observed (days)
1199
1396
Number of mice at start
45
95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
DMAG effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.6841
p = 0.4082
Wang-Allison test
odds ratio = 1.5925
p = 0.4076
Quantiles
DMAG
Control
% difference
25% died before day:
631
608
+4 %
Median lifespan (days)
833
818
+2 %
75% died before day:
1029
942
+9 %
90% died before day:
1102
1061
+4 %
Max lifespan observed (days)
1221
1237
Number of mice at start
53
92
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
DMAG effect on survival,
females, test site = UM
Log-rank test
chisq = 3.3961
p = 0.0653
Wang-Allison test
odds ratio = 0.3234
p = 0.2246
Quantiles
DMAG
Control
% difference
25% died before day:
708
791
-10 %
Median lifespan (days)
854
899
-5 %
75% died before day:
969
992
-2 %
90% died before day:
1002
1079
-7 %
Max lifespan observed (days)
1160
1291
Number of mice at start
43
91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
DMAG effect on survival,
males, test site = UM
Log-rank test
chisq = 0.0091
p = 0.9241
Wang-Allison test
odds ratio = 0.4758
p = 0.3692
Quantiles
DMAG
Control
% difference
25% died before day:
644
601
+7 %
Median lifespan (days)
841
740
+14 %
75% died before day:
918
905
+1 %
90% died before day:
1005
1027
-2 %
Max lifespan observed (days)
1096
1231
Number of mice at start
48
81
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
DMAG effect on survival,
females, test site = UT
Log-rank test
chisq = 0.0109
p = 0.9168
Wang-Allison test
odds ratio = 1.5732
p = 0.5496
Quantiles
DMAG
Control
% difference
25% died before day:
762
786
-3 %
Median lifespan (days)
866
892
-3 %
75% died before day:
1014
1014
0 %
90% died before day:
1085
1078
+1 %
Max lifespan observed (days)
1219
1280
Number of mice at start
44
88
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
DMAG effect on survival,
males, test site = UT
Log-rank test
chisq = 3.0031
p = 0.0831
Wang-Allison test
odds ratio = 1.6445
p = 0.4002
Quantiles
DMAG
Control
% difference
25% died before day:
677
500
+35 %
Median lifespan (days)
856
786
+9 %
75% died before day:
1007
888
+13 %
90% died before day:
1106
1025
+8 %
Max lifespan observed (days)
1215
1220
Number of mice at start
51
91
Animal censor events are denoted by + marks in the plot
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Statistical definitions