ITP survival analysis: curcumin
Intervention:
curcumin
dietary supplement
Trial code: Cur
Dose: 2000 ppm
initiated at age: 4 mo
Sex: both
Cohort: C2007
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
Cur effect on survival,
females, test site = All
Log-rank test
chisq = 0.5851
p = 0.4443
Wang-Allison test
odds ratio = 1.3315
p = 0.389
Quantiles
Cur
Control
% difference
25% died before day:
749
753
-1 %
Median lifespan (days)
905
865
+5 %
75% died before day:
1029
994
+4 %
90% died before day:
1091
1088
0 %
Max lifespan observed (days)
1385
1359
Number of mice at start
131
275
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
Cur effect on survival,
males, test site = All
Log-rank test
chisq = 0.0346
p = 0.8524
Wang-Allison test
odds ratio = 1.0141
p = 1.0
Quantiles
Cur
Control
% difference
25% died before day:
647
588
+10 %
Median lifespan (days)
804
784
+3 %
75% died before day:
942
954
-1 %
90% died before day:
1057
1074
-2 %
Max lifespan observed (days)
1337
1247
Number of mice at start
146
276
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
Cur effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.3902
p = 0.5322
Wang-Allison test
odds ratio = 1.2116
p = 0.7666
Quantiles
Cur
Control
% difference
25% died before day:
808
740
+9 %
Median lifespan (days)
948
860
+10 %
75% died before day:
1039
1016
+2 %
90% died before day:
1122
1111
+1 %
Max lifespan observed (days)
1246
1340
Number of mice at start
43
92
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
Cur effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.6249
p = 0.4292
Wang-Allison test
odds ratio = 0.9424
p = 1.0
Quantiles
Cur
Control
% difference
25% died before day:
648
569
+14 %
Median lifespan (days)
800
728
+10 %
75% died before day:
906
923
-2 %
90% died before day:
1020
1039
-2 %
Max lifespan observed (days)
1337
1200
Number of mice at start
51
87
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
Cur effect on survival,
females, test site = UM
Log-rank test
chisq = 0.0194
p = 0.8892
Wang-Allison test
odds ratio = 0.8113
p = 1.0
Quantiles
Cur
Control
% difference
25% died before day:
789
767
+3 %
Median lifespan (days)
878
900
-2 %
75% died before day:
1037
999
+4 %
90% died before day:
1112
1114
0 %
Max lifespan observed (days)
1187
1359
Number of mice at start
44
91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
Cur effect on survival,
males, test site = UM
Log-rank test
chisq = 1.1816
p = 0.277
Wang-Allison test
odds ratio = 2.2486
p = 0.2268
Quantiles
Cur
Control
% difference
25% died before day:
657
659
0 %
Median lifespan (days)
838
793
+6 %
75% died before day:
976
953
+2 %
90% died before day:
1116
1076
+4 %
Max lifespan observed (days)
1237
1191
Number of mice at start
45
93
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
Cur effect on survival,
females, test site = UT
Log-rank test
chisq = 0.3129
p = 0.5759
Wang-Allison test
odds ratio = 2.2819
p = 0.1449
Quantiles
Cur
Control
% difference
25% died before day:
686
756
-9 %
Median lifespan (days)
808
840
-4 %
75% died before day:
1012
962
+5 %
90% died before day:
1067
1045
+2 %
Max lifespan observed (days)
1385
1261
Number of mice at start
44
92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
Cur effect on survival,
males, test site = UT
Log-rank test
chisq = 2.6838
p = 0.1014
Wang-Allison test
odds ratio = 0.449
p = 0.2641
Quantiles
Cur
Control
% difference
25% died before day:
600
584
+3 %
Median lifespan (days)
758
810
-6 %
75% died before day:
941
1010
-7 %
90% died before day:
1040
1132
-8 %
Max lifespan observed (days)
1163
1247
Number of mice at start
50
96
Animal censor events are denoted by + marks in the plot
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ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions