ITP survival analysis: canagliflozin
Intervention:
canagliflozin
Type 2 diabetes drug
Trial code: Cana
Dose: 180 ppm
initiated at age: 7 mo
Sex: both
Cohort: C2016
This compound had a significant effect on survival: males p < 0.0001
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
Cana effect on survival,
females, test site = All
Log-rank test
chisq = 0.4299
p = 0.512
Wang-Allison test
odds ratio = 1.259
p = 0.4985
Quantiles
Cana
Control
% difference
25% died before day:
764
790
-3 %
Median lifespan (days)
883
875
+1 %
75% died before day:
990
975
+2 %
90% died before day:
1089
1055
+3 %
Max lifespan observed (days)
1320
1339
Number of mice at start
136
303
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
Cana effect on survival,
males, test site = All
Log-rank test
chisq = 25.0831
p < 0.0001
Wang-Allison test
odds ratio = 4.1325
p < 0.0001
Quantiles
Cana
Control
% difference
25% died before day:
774
608
+27 %
Median lifespan (days)
888
782
+14 %
75% died before day:
1067
935
+14 %
90% died before day:
1159
1055
+10 %
Max lifespan observed (days)
1363
1264
Number of mice at start
145
275
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
Cana effect on survival,
females, test site = TJL
Log-rank test
chisq = 1.8565
p = 0.173
Wang-Allison test
odds ratio = 1.8482
p = 0.2625
Quantiles
Cana
Control
% difference
25% died before day:
800
816
-2 %
Median lifespan (days)
912
883
+3 %
75% died before day:
1040
971
+7 %
90% died before day:
1097
1057
+4 %
Max lifespan observed (days)
1290
1230
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
Cana effect on survival,
males, test site = TJL
Log-rank test
chisq = 12.1813
p = 0.0005
Wang-Allison test
odds ratio = 5.816
p = 0.0031
Quantiles
Cana
Control
% difference
25% died before day:
773
608
+27 %
Median lifespan (days)
880
749
+17 %
75% died before day:
1075
891
+21 %
90% died before day:
1159
1005
+15 %
Max lifespan observed (days)
1243
1262
Number of mice at start
53
94
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
Cana effect on survival,
females, test site = UM
Log-rank test
chisq = 1.2528
p = 0.263
Wang-Allison test
odds ratio = 1.6514
p = 0.3802
Quantiles
Cana
Control
% difference
25% died before day:
723
788
-8 %
Median lifespan (days)
896
858
+4 %
75% died before day:
990
961
+3 %
90% died before day:
1076
1034
+4 %
Max lifespan observed (days)
1320
1189
Number of mice at start
44
92
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
Cana effect on survival,
males, test site = UM
Log-rank test
chisq = 11.4246
p = 0.0007
Wang-Allison test
odds ratio = 8.3273
p = 0.0009
Quantiles
Cana
Control
% difference
25% died before day:
808
534
+51 %
Median lifespan (days)
946
814
+16 %
75% died before day:
1105
996
+11 %
90% died before day:
1170
1071
+9 %
Max lifespan observed (days)
1363
1258
Number of mice at start
41
82
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
Cana effect on survival,
females, test site = UT
Log-rank test
chisq = 2.1588
p = 0.1418
Wang-Allison test
odds ratio = 0.5815
p = 0.5598
Quantiles
Cana
Control
% difference
25% died before day:
749
774
-3 %
Median lifespan (days)
849
882
-4 %
75% died before day:
932
984
-5 %
90% died before day:
1003
1058
-5 %
Max lifespan observed (days)
1205
1339
Number of mice at start
44
116
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
Cana effect on survival,
males, test site = UT
Log-rank test
chisq = 3.5266
p = 0.0604
Wang-Allison test
odds ratio = 1.8021
p = 0.3887
Quantiles
Cana
Control
% difference
25% died before day:
740
640
+16 %
Median lifespan (days)
866
799
+8 %
75% died before day:
1035
936
+11 %
90% died before day:
1099
1064
+3 %
Max lifespan observed (days)
1252
1264
Number of mice at start
51
99
Animal censor events are denoted by + marks in the plot
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National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions