ITP survival analysis:   canagliflozin

Intervention:   canagliflozin     Type 2 diabetes drug; anti-aging
Trial code: Cana Dose: 180 ppm initiated at age: 7 mo Sex: both Cohort: C2016
This compound had a significant effect on survival:   males p < 0.0001

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
Cana effect on survival, females, test site = All
Log-rank test chisq = 0.4299 p = 0.512
Wang-Allison test odds ratio = 1.259 p = 0.4985
Quantiles Cana Control % difference
25% died before day: 764 790 -3 %
Median lifespan (days) 883 875 +1 %
75% died before day: 990 975 +2 %
90% died before day: 1089 1055 +3 %
Max lifespan observed (days) 1320 1339
Number of mice at start 136 303
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Cana effect on survival, males, test site = All
Log-rank test chisq = 25.0831 p < 0.0001
Wang-Allison test odds ratio = 4.1325 p < 0.0001
Quantiles Cana Control % difference
25% died before day: 774 608 +27 %
Median lifespan (days) 888 782 +14 %
75% died before day: 1067 935 +14 %
90% died before day: 1159 1055 +10 %
Max lifespan observed (days) 1363 1264
Number of mice at start 145 275
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
Cana effect on survival, females, test site = TJL
Log-rank test chisq = 1.8565 p = 0.173
Wang-Allison test odds ratio = 1.8482 p = 0.2625
Quantiles Cana Control % difference
25% died before day: 800 816 -2 %
Median lifespan (days) 912 883 +3 %
75% died before day: 1040 971 +7 %
90% died before day: 1097 1057 +4 %
Max lifespan observed (days) 1290 1230
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
Cana effect on survival, males, test site = TJL
Log-rank test chisq = 12.1813 p = 0.0005
Wang-Allison test odds ratio = 5.816 p = 0.0031
Quantiles Cana Control % difference
25% died before day: 773 608 +27 %
Median lifespan (days) 880 749 +17 %
75% died before day: 1075 891 +21 %
90% died before day: 1159 1005 +15 %
Max lifespan observed (days) 1243 1262
Number of mice at start 53 94
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
Cana effect on survival, females, test site = UM
Log-rank test chisq = 1.2528 p = 0.263
Wang-Allison test odds ratio = 1.6514 p = 0.3802
Quantiles Cana Control % difference
25% died before day: 723 788 -8 %
Median lifespan (days) 896 858 +4 %
75% died before day: 990 961 +3 %
90% died before day: 1076 1034 +4 %
Max lifespan observed (days) 1320 1189
Number of mice at start 44 92
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
Cana effect on survival, males, test site = UM
Log-rank test chisq = 11.4246 p = 0.0007
Wang-Allison test odds ratio = 8.3273 p = 0.0009
Quantiles Cana Control % difference
25% died before day: 808 534 +51 %
Median lifespan (days) 946 814 +16 %
75% died before day: 1105 996 +11 %
90% died before day: 1170 1071 +9 %
Max lifespan observed (days) 1363 1258
Number of mice at start 41 82
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
Cana effect on survival, females, test site = UT
Log-rank test chisq = 2.1588 p = 0.1418
Wang-Allison test odds ratio = 0.5815 p = 0.5598
Quantiles Cana Control % difference
25% died before day: 749 774 -3 %
Median lifespan (days) 849 882 -4 %
75% died before day: 932 984 -5 %
90% died before day: 1003 1058 -5 %
Max lifespan observed (days) 1205 1339
Number of mice at start 44 116
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
Cana effect on survival, males, test site = UT
Log-rank test chisq = 3.5266 p = 0.0604
Wang-Allison test odds ratio = 1.8021 p = 0.3887
Quantiles Cana Control % difference
25% died before day: 740 640 +16 %
Median lifespan (days) 866 799 +8 %
75% died before day: 1035 936 +11 %
90% died before day: 1099 1064 +3 %
Max lifespan observed (days) 1252 1264
Number of mice at start 51 99
Animal censor events are denoted by + marks in the plot


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Statistical definitions